News
Nuvo and Sheba Medical Centre collaboration brings AI into pregnancy care
The early-stage collaboration includes the evaluation of a new virtual care regimen for managing gestational diabetes
An FDA-approved remote pregnancy monitoring platform has announced a collaboration agreement with Israel’s Sheba Medical Centre.
The Nuvo Group is the creator of INVU, a pregnancy monitoring and management system.
The first phase of its partnership with the Sheba Medical Centre consisted of a pilot programme around gestational diabetes management, in which medically necessary non-stress tests (NSTs) were shifted to home-based remote monitoring using INVU rather than conducting traditional monitoring in a physical medical facility.
A NST is a common prenatal test used to check on a baby’s health, during which the baby’s heart rate is monitored to see how it responds to the baby’s movements.
As part of the partnership, participating physicians prescribed INVU to expectant mothers, who wore the sensor band from home during virtual visits.
During these virtual visits anchored by the hospital’s Sheba BEYOND, virtual hospital platform, a live reading allowed the expectant mother to access data and insights via the INVU app, while the provider received more detailed foetal and maternal surveillance that OB/GYNs are accustomed to receiving during in-office visits.
The pilot programme also included the use of several other telemedicine solutions alongside INVU, including a remote ultrasound device, glucose monitoring, and home urinalysis kit.
In addition to offering a safe and proven regimen for managing gestational diabetes, the programme aimed to help patients and providers save time and improve the overall care experience.
For the next phase of the partnership, Nuvo and Sheba intend to work together to integrate the INVU platform into the hospital’s standard of care protocols, planning to utilise data collected from the pilot programme to develop new AI tools to advance pregnancy care management and lower costs.
“Our long term goal is to provide pregnant women with the best possible maternal-foetal surveillance wherever they are – in our clinics, at the comfort of their home or during their work day,” says Dr Avi Tsur, high-risk pregnancy expert and director of Sheba’s Women’s Health Innovation Center and Sheba BEYOND’s Obstetrics & Gynaecology Beyond tele-health platform.
“The INVU foetal monitoring solution has the potential to be a catalyst of transformative care in an area of medicine that has been lagging in innovation and new approaches for decades. I hope this pilot is only the beginning.”
Dr Galia Barkai, director of Sheba BEYOND, says : “Sheba Beyond is constantly adopting cutting-edge technologies, which are enabling patients to receive the best care in the comfort of their homes. This collaboration is yet another step towards our goal to bring high level, hospital care, to everyone, everywhere.”
Kelly Londy, CEO of Nuvo Group, says it is an honour to collaborate with Sheba.
She adds: “The INVU platform is particularly beneficial for high-risk pregnancies that would otherwise require frequent in-office visits, which we know can become burdensome on all sides.
“We look forward to the next phase of our partnership as we continue to work with Sheba to help deliver safe and reliable remote care to even more patients.”
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
Insight
Higher nighttime temps linked to increased risk of autism diagnosis in children – study
Entrepreneur
Kindbody unveils next-gen fertility platform
-
Fertility4 weeks agoDesigner perfumes recalled over banned chemical posing fertility risk
-
Insight2 weeks agoParents sue IVF clinic after delivering someone else’s baby
-
Insight3 weeks agoWomen’s health could unlock US$100bn by 2030
-
Insight4 weeks agoChina’s birth rate hits record low despite government fertility efforts
-
Menopause3 weeks agoHRT linked to greater weight loss on tirzepatide
-
Entrepreneur5 days agoUS startup builds wearable hormone tracker
-
Menopause2 weeks agoFlo Health and Mayo Clinic publish global perimenopause awareness study
-
News4 weeks agoVerdane invest in Clue to accelerate the future of women’s health






