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Pioneering technology to address threatened miscarriage secures £1 million funding

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Dr Zibners is co-founder of Calla Lily Clinical Care (CLCC), a company changing the way women are treated for a range of medical conditions from infertility to cervical cancer to a healthy vaginal microbiome.

The company has developed the Callavid platform for leak-free vaginal drug delivery.

This week they are announcing a prestigious £1 million ($1.29 million) award of NIHR funding to begin clinical trials for their first use-case: progesterone, a drug that is commonly used for a variety of conditions including infertility, miscarriage prevention, preterm birth prevention, and menopause. 

Why progesterone?

Because of Dr Zibners’ personal experience on her journey to motherhood.

She said: “I never thought, oh let me try to get pregnant and then there will be seven rounds of failed IVF and one day I’ll start a women’s healthcare company.

“It just turned out that way.”

She is always quick to add that she is the mother of three, thanks to adoption and surrogacy.

On the way there, however, she became intimately knowledgeable about the leaky pessaries and very painful muscular injections that are part of taking progesterone.

In the UK, vaginal pessaries are the standard but cause a great deal of anxiety due to leakage, with women being advised to lie down for at least half an hour after administering the drug, two or three times each day.

A US-trained physician, Dr Zibners started on vaginal progesterone during her infertility journey, but because of the leakage and dosage uncertainty she was quickly moved to the injected formulation.

She said: “There will be different needles in the bag, that’s what my doctor said. But progesterone wasn’t like the other injections.

“It is an oil-based, very thick, emulsion that needs to go into a large muscle.

“For five months, I had to steel myself every single time before plunging that needle into my own hip. It was traumatic.”

                         Dr Lara Zibners

The announcement of such significant funding support from the NIHR (National Institute for Health and Care Research) is a significant validation for the company.

As the UK’s leading funder of health and social care research, grant applicants must align with the NIHR’s focus on bettering society through impactful innovation.

These grants are not easy to come by and this was not their first attempt. Each application is hundreds of pages long and consumes very many hours of a start-up’s scarce resources.

The possibility of a prestigious source of non-dilutive funding kept the team moving forward with a resubmission.  

The monies received will fund the company’s first clinical feasibility trial starting later this year.

Vaginal micronised progesterone is recommended by the UK’s National Institute for Health and Care Excellence (NICE) for every woman who has had at least one prior miscarriage and faces a “threatened miscarriage,” defined as bleeding in early pregnancy.

While this is national guidance in the UK and there is similar guidance in Australia, Dr Zibners maintains that progesterone for early pregnancy support is used around the world.

She said: “In a certain number of patients, there are inadequate levels of circulating progesterone to support the endometrium as a pregnancy takes root and develops a sure footing in there.

“By giving progesterone, there is evidence that up to 15 per cent of miscarriages in patients with recurrent pregnancy loss could be prevented.” 

Calla Lily Clinical Care is being fast-tracked through the UK regulatory body, the MHRA (US FDA equivalent), for both infertility support and miscarriage prevention.

If, following their clinical studies, the vaginal progesterone product is approved, it will become the world’s first drug-device combination to prevent miscarriage.  

The Callavid device is similar to a tampon but has been adapted to release drug while selectively absorbing leakage.

A mini-liner that remains external to the body has been integrated into the device to absorb any additional fluid and for completely hygienic removal after the prescribed wearing time.

Dr Zibners has partnered with Thang Vo-Ta, a former Goldman Sachs investment banker with a long history in the women’s health space to bring their vision to life. 

The upcoming study is being led by Professor Siobhan Quenby MBE, a world leading expert on recurrent miscarriage.

In the company’s press release, Professor Quenby is quoted as saying: “This new product will be extremely welcomed by miscarriage patients.

“Pessary leakage is a common issue amongst my patients, causing acute anxiety and significant inconvenience during a very difficult time…Through this innovation…I believe there is potential to transform women’s experience.” 

Dr Zibners echoed the Professor’s sentiment: “If I had been able to use this product, my IVF journey would have been better. Simple as that.

“Once women know there is a different option, why would you ever allow yourself to go through the trauma of injections or leaky pessaries?”

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Femtech World Awards 2026: Celebrating initiatives that move women’s health forward

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By Wolfgang Hackl, CEO, OncoGenomX Inc., Allschwil, Switzerland

As the FemTech World Awards 2026 winners are revealed, it is a privilege to reflect on the Research Award 2026 sponsored by OncoGenomX Inc., and on the exceptional standard set by this year’s finalists.

On behalf of OncoGenomX Inc., sincere thanks to every applicant and congratulations go to the nominees whose work continues to push women’s health innovation forward.

Research Awards matter because they do more than recognize excellence in a single moment; they help elevate the science, courage, and systems thinking needed to transform women’s health at scale.

This year’s three finalists represented three different but equally important forms of progress. Natural Cycles brought forward one of the largest studies ever conducted on menstrual and ovulatory patterns in perimenopause, analysing nearly one million cycles from more than 197,000 women across over 140 countries.

That project stood out for both its dataset scale and its ability to translate new evidence into a regulated product designed to support women navigating a historically under-researched life stage.

IVI RMA stood out for scientific rigor and clinical precision. Its multicenter, double-blinded, non-selection study on non-mosaic segmental aneuploid embryos offered high-quality evidence on implantation and live birth outcomes, helping move fertility care away from assumption and toward a more evidence-based approach to embryo management and patient counseling.

UN ESCAP’s ‘Femtech in South-East Asia: Unlocking innovation for women’s health’ stood out for a different reason.

Rather than focusing on one product area or one clinical question, it mapped an entire emerging ecosystem.

The report examined the state of femtech across key South-East Asian markets, documented barriers such as financing gaps, stigma, weak ecosystem support, and data challenges, and then translated that research into practical recommendations for governments, investors, founders, and ecosystem builders.

In many ways, all three finalists are winners.

Each project excelled on core evaluation criteria including originality, relevance, coherence, effectiveness, efficiency, impact, and sustainability.

Each also offered something genuinely valuable to the future of women’s health: stronger evidence, clearer decision-making, more informed product development, and greater visibility for unmet needs that have gone too long without sufficient attention.

The final decision was therefore a genuine head-to-head race.

The jury supported its discussion with a numerical scoring approach, but it also looked carefully at systems impact: the extent to which a project not only advances one intervention, but improves the wider conditions under which innovation can emerge, scale, and endure.

That perspective mattered in this category, because the strongest research is not always only the most technically impressive; sometimes it is the research that opens doors for many future innovations to follow.

On that basis, the OncoGenomX Jury selected UN ESCAP as the winner of the Research Award.

The decisive factor was not simply that the report was comprehensive, though it was.

It was that the project helps change the environment around innovation itself.

It provides a practical roadmap for strengthening research, improving data governance, expanding founder support, addressing gender bias in investment, scaling innovative finance, and integrating women’s health more fully into policy and development agendas.

That broader enabling effect is what distinguished the UN ESCAP project. Natural Cycles demonstrated outstanding research translation, and IVI RMA demonstrated exceptional clinical rigor.

UN ESCAP, however, showed how research can influence the structures that determine whether many other femtech solutions will ever be funded, adopted, trusted, and scaled. In that sense, its impact reaches beyond one company, one product, or one clinical pathway, and toward a healthier innovation landscape overall.

Warm congratulations again to all finalists and nominees.

And special congratulations to UN ESCAP on receiving the OncoGenomX Research Award at the Femtech World Awards 2026.

The jury’s decision reflects deep respect for all three projects and a shared belief that women’s health advances fastest when excellent science is paired with the power to reshape the systems around it.

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WEC Chair calls out Health Minister’s delay on banning BBLs and other harmful cosmetic procedures

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WEC chair Sarah Owen has criticised delays over a ban on high harm cosmetic procedures, including liquid BBLs.

The Women and Equalities Committee has published a letter from health minister Karin Smyth after the government missed the 18 April deadline to respond to the committee’s report on cosmetic procedures.

The report, published on 18 February, recommended that high harm procedures such as liquid Brazilian butt lifts, known as BBLs, should be banned immediately without further consultation.

MPs said the government is “not moving quickly enough” in introducing a licensing system for non-surgical cosmetic procedures and “should accelerate regulatory action”.

They also warned that “this lack of timely action is fostering complacency in self-regulation” within the industry.

In her letter, Smyth said the Department of Health and Social Care had “taken the decision to first of all focus on introducing legal safeguards for the cosmetic procedures posing the highest risks and I can confirm that we plan to consult on draft regulations in June”.

The letter added:

“Our intention is to issue a formal government response to the WEC report, once our consultation setting out our proposed approach and underpinning legislation is published.

“I acknowledge the concerns around the government’s pace of delivery in this area but, as you will appreciate, this is a complex area of policy and striking the balance between increased patient safety, placing new requirements on businesses and introducing proportionate and enforceable regulation is challenging.

“I recognise that regulation has not kept pace with the expansion of the aesthetics industry and, on that basis, I can assure you that we are committed to implementing licensing in the current parliament.”

Owen, chair of the Women and Equalities Committee and Labour MP, said:

“Further consultation and delay on clamping down on high harm procedures such as liquid BBLs is unacceptable. It allows unscrupulous people to continue to put women at risk and lets down those who have lost loved ones following these practices or who have come to serious harm themselves.

“As WEC’s report warned back in February, procedures that are deemed high risk such as liquid BBLs and liquid breast augmentations, which have already been shown to pose a serious threat to patient safety, should be banned immediately.

“While it is positive to hear a licensing system for non-surgical cosmetic procedures will be introduced within this Parliament, this issue requires faster regulatory progress, particularly in high harm areas, and the Government is not moving quickly enough.

“The Committee previously heard a powerful and shocking testimony from a woman who developed sepsis after having a liquid BBL. Her experience and those of many others provides clear evidence of the need to tackle this evolving wild west.”

A liquid BBL is a non-surgical procedure intended to alter the shape of the buttocks.

Sepsis is a potentially life-threatening response to infection that can lead to organ damage if not treated quickly.

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Menopausal hormone therapy could prevent bone loss or lower fracture risk – study

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Women who do not use menopausal hormone therapy have a greater risk of developing osteopenia or osteoporosis, conditions that weaken bones and can lead to fractures, disability and loss of independence, new research suggests.

The retrospective cohort study included 387 postmenopausal women who underwent DXA scans between 2021 and 2025. A DXA scan is an imaging test used to measure bone mineral density.

Participants were classed as menopausal hormone therapy users, who made up 33 per cent of the group, or non-users, who made up 67 per cent.

Low bone mineral density was defined as osteopenia, where bones are weaker than normal, or osteoporosis, where bones become more fragile and more likely to break.

Women taking menopausal hormone therapy had about 69 per cent lower risk of low bone mineral density in the spine and hip compared with those not using it.

The association remained after researchers accounted for age, time since menopause, vitamin D levels, smoking and other health conditions.

Diego Espinoza-Peralta, vice president of the Mexican Society of Nutrition and Endocrinology and principal investigator at Investigación Médica Sonora, said: “For years, many women have avoided menopausal hormone therapy because of safety concerns and warning labels.

“This study revisits that narrative and shows that menopausal hormone therapy may have an important added benefit: protecting bone health. That shifts the conversation from ‘avoid if possible’ to ‘reconsider in the right patient.’

“In simple terms: menopausal hormone therapy appears to independently protect bones, not just by coincidence.”

The findings suggest hormone therapy could help some women find relief from menopausal symptoms while preventing bone loss or lowering fracture risk.

Espinoza-Peralta said: “Clinicians may begin to weigh its benefits more carefully, especially in women early after menopause, potentially improving long-term health and quality of life.”

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