News
UK ‘leading the way’ in women’s health innovation, say experts
Panelists have praised the UK’s progress at this week’s Women’s Health Innovation Summit
The UK is leading the way in women’s health innovation and policy change, experts have said, as the femtech market is projected to grow.
Speaking at the Women’s Health Innovation Summit Europe 2023 taking place in Basel this week, Valentina Sartori, partner at McKinsey & Company, said European countries have made “significant” steps in femtech and digital health.
“I think we’ve seen great progress in women’s health,” she said. “We’ve seen much more investment going into menopause and much more investment in femtech overall.
“We had around US$2.4b in funding last year in femtech and a lot of that went to companies here in Europe which is fantastic to see. The UK is leading the way, with around 40 per cent of the investment going there.”
The panelists have also praised England’s Women’s Health Strategy, launched earlier last year with the aim to improve the way in which the health and care system listens to women’s voices and boost health outcomes for women and girls.
Sartori noted that policymakers are doing more, highlighting the UK’s latest policies for pregnant women as well as Spain’s decision to introduce paid menstrual leave.
Priya Oberoi, general partner at Goddess Gaia Ventures, said: “When it comes to government changes, lobbying is very important and the UK has done very well.
“We’ve had a number of roundtables at No 10 and we’ve been able to encourage real change.
“As a VC, our job is basically betting on the future and we are betting on the use of technology in healthcare, and how that will improve women’s lives.”
Although the UK government has decided against providing special protection for menopausal employees, it has stressed its commitment to improve access to care for essential services for menstrual problems, contraception, pelvic pain and menopause care.
A £25m investment was allocated in March to create new health hubs for women in England while further investment was dedicated to 17 new specialist pregnancy centres, as part of the NHS commitment to halve the maternal mortality rate by 2025.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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