Cancer
Merck’s cancer immunotherapy Keytruda shows breakthrough results in resistant ovarian cancer

Merck’s immunotherapy drug Keytruda (pembrolizumab) has shown a “statistically significant” survival benefit in platinum-resistant ovarian cancer, potentially offering a new treatment path for patients with few options.
In the phase 3 Keynote-B96 trial, the checkpoint inhibitor—used in combination with chemotherapy, with or without Avastin—led to improvements in progression-free survival compared to placebo and chemotherapy alone.
These interim results mark a potential turning point. It’s the first time an immune checkpoint inhibitor has demonstrated a survival benefit in ovarian cancer, a notoriously difficult-to-treat “cold tumour” that typically responds poorly to immunotherapy.
Merck reported that Keytruda was effective regardless of patients’ PD-L1 expression levels.
The positive results from this trial add to the growing body of evidence supporting the potential benefit of Keytruda across gynaecological cancers, including this difficult-to-treat form of ovarian cancer for which patients are in need of new options,” said Gursel Aktan, vice president of global clinical development at Merck Research Laboratories.
This success comes after several high-profile setbacks in the field. Although Keytruda is approved for more than 40 indications, it previously failed to show survival benefits in combination with Lynparza for first-line BRCA non-mutated advanced epithelial ovarian cancer.
Other companies have faced similar challenges. GSK’s combination of Jemperli and Zejula also failed to significantly extend survival in first-line advanced ovarian cancer last year, underscoring the difficulty of treating this disease.
Ovarian cancer is the seventh most common cancer among women globally. In the U.S. alone, it’s expected to cause an estimated 12,730 deaths and 20,890 new diagnoses this year, according to Merck.
The company plans to present full results at an upcoming medical conference and submit data to regulators worldwide, potentially paving the way for a new treatment option in a space where few exist.
This development follows Keytruda’s recent success in another challenging cancer type—late-stage, resected, locally advanced head and neck squamous cell carcinoma—where it became the first therapy in 20 years to show a positive trial outcome.
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Diagnosis
Women unaware of gynaecological cancers

Only one per cent of women can name all five gynaecological cancers, new research suggests, as 21 women in the UK die every day of the diseases.
The report also found that 31 per cent of women have put off or avoided seeking medical advice for gynaecological symptoms.
It also found that 43 per cent of women invited for cervical screening said barriers had put them off attending, while 18 per cent of respondents aged 25 to 34 who had been invited had never attended.
The five main gynaecological cancers are womb, also called uterine, ovarian, cervical, vulval and vaginal cancer.
The Lady Garden Foundation said that, while progress has been made since the UK government’s 2022 Women’s Health Strategy aimed to improve gynaecological cancer care, significant challenges remain.
John Butler, medical director and trustee at the Lady Garden Foundation, said: “The fact that only one per cent of the population can name the diseases that directly affect half of us underscores a significant awareness gap, impacting individuals’ ability to recognise vital signs and symptoms or seek timely medical help.
“Addressing this isn’t just about awareness; it’s a critical public health priority. Our collective efforts are essential to ensure the latest commitments announced by this government translate into tangible change that saves lives.”
The report said key reasons for delaying medical advice included difficulty making appointments, embarrassment and, for cervical screening, fear of pain or previous bad experiences.
Women also reported challenges within healthcare interactions, including feeling “not taken seriously”, “dismissed” or “not believed” when seeking gynaecological advice.
Jenny Halpern Prince, chief executive and charity co-founder, said: “We frequently hear reports of women feeling ‘not taken seriously,’ ‘dismissed,’ or ‘not believed’ when seeking gynaecological advice.
“These experiences highlight crucial areas where we can improve patient support and trust within our healthcare system, ensuring women receive the empathetic and effective care they need.”
The Lady Garden Foundation said it aims to increase awareness of both the charity and the five gynaecological cancers.
It also aims to serve as a primary entry point for reliable, stigma-free information, helping people understand their bodies, recognise symptoms and overcome barriers to accessing care.
Its Silent No More Garden was unveiled at the RHS Chelsea Flower Show 2026. Designed by Darren Hawkes, the garden serves as a national call to action, using five sculptures to spark conversations, break long-standing taboos and encourage open dialogue about symptoms and preventative care.
Butler said: “Continued focus and collaborative action are essential to progress.
“The ongoing commitment from the government, alongside societal efforts to break down taboos surrounding gynaecological health, are crucial.
“The Lady Garden Foundation is dedicated to being a beacon of information and support, empowering women with the knowledge they need. We urge everyone to learn the signs, speak up, and help us save lives.”
Fertility
AI could transform ovarian care through personalisation, study finds

AI could transform ovarian care by personalising cancer and fertility treatment, but more clinical validation is needed before routine use.
A systematic review and meta-analysis found AI models showed high diagnostic accuracy for ovarian cancer when combining data such as ultrasound scans and blood test results.
Across 81 studies, AI models correctly identified ovarian cancer in around nine out of 10 cases, with pooled rates of 89 to 94 per cent.
They were also highly accurate at ruling out ovarian cancer when it was not present, with specificity of 85 to 91 per cent.
The analysis also found that explainable AI tools could predict complete surgical cytoreduction in advanced ovarian cancer.
Complete surgical cytoreduction means removing all visible cancer during surgery, which can be an important goal in treatment planning.
The tools achieved a pooled AUC of 0.87. AUC is a measure of how well a model distinguishes between different outcomes, with higher scores showing stronger performance.
In reproductive medicine, AI algorithms helped physicians optimise ovarian stimulation protocols and predict follicular growth during IVF.
Ovarian stimulation is the use of hormones to encourage the ovaries to produce eggs, while follicles are the small sacs in the ovaries where eggs develop.
The review found AI could reliably model ovarian response in IVF with a pooled AUC of 0.81.
However, researchers said challenges remain in translating promising research findings into routine clinical practice.
They identified substantial variation across studies, driven by retrospective study designs, variable AI systems and a lack of standardised validation.
Only 22 per cent of analysed studies reported prospective, multicentre external validation, where models are tested forward in time across multiple healthcare settings.
The authors called for rigorous validation to help close the gap between research and routine clinical practice, alongside standardised methodological and reporting frameworks, smooth integration with clinical workflow and robust governance to support responsible and ethical AI use.
They concluded: “Artificial intelligence is a transformative force in the management of ovarian conditions.
“In gynaecologic oncology, AI enhances every phase of care, from early detection and accurate diagnosis to prognostic stratification and surgical planning.”
In reproductive medicine, AI personalises ovarian stimulation and refines the diagnosis of heterogenous endocrine disorders such as PCOS.
PCOS, or polycystic ovary syndrome, is a hormonal condition that can affect periods, skin, weight and fertility.
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