News
Study shows CHLOE AI’s role in advancing reproductive health research
Researchers can use Fairtility’s AI tool to further their understanding of embryo and oocyte development

Fairtility, the transparent AI innovator powering reproductive care for improved outcomes, has announced the highlights of a new study published in Nature’s Scientific Reports.
The study, focused on blastocyst morphometric parameters’ impact on implantation potential, highlights how Fairtility’s transparent AI decision support technology, CHLOE, can support academic research in the field of assisted reproductive technologies.
The study, entitled An artificial intelligence algorithm for automated blastocyst morphometric parameters demonstrates a positive association with implantation potential, was led by Professor Iris Har Vardi, director of Fertility and IVF Lab at Soroka University Medical Center and senior lecturer at Ben Gurion University in the Faculty of Health Sciences. Har Vardi also serves as a scientific advisor to Fairtility.

Automatic measurements of blastocyst morphometrics. (a) A day-5 blastocyst with trophectoderm (TE) and inner cell mass (ICM) cells. (b) The same embryo with markings. Blue represents the hand drawn segmentation around the outer part of the TE cells, excluding the area occupied by the zona pellucida. Green represents the ellipse that best fits around the segmented ICM pixels in the least-squares sense. Red represents the diameter of the embryo.
The study included 608 transferred blastocysts that were selected using morphokinetics and Gardner criteria. Retrospectively, researchers deployed CHLOE to automatically assess four morphometric parameters: blastocyst size, inner cell mass (ICM) size, ICM-to-blastocyst size ratio and ICM shape.
Researchers found that blastocyst size had a significant positive association with implantation such that with every 1 μm increase in blastocyst size, there was a relative increase in the odds of implantation by 2.1 per cent.
Applying CHLOE to assess these parameters retrospectively, was possible due to CHLOE’s advanced, consistent and automated assessment.
These capabilities enable researchers to study various events, biomarkers, timing and ratios objectively that were previously not possible, providing new insights for treatment decisions and opening up tremendous opportunity for more research to advance the field.
“CHLOE’s AI algorithms enabled us to measure various embryo components automatically with higher accuracy and speed than us, the embryologists,” explained Professor Har Vardi.
“As a researcher and a clinical embryologist, AI provides a powerful new tool and opens endless possibilities to further explore basic science and clinical parameters.

Professor Iris Har Vardi, director of Fertility and IVF Lab at Soroka University Medical Center and senior lecturer at Ben Gurion University
“This research highlights the potential for enhanced blastocyst selection in the IVF process using AI technology, which offers great promise for improving the effectiveness and personalisation of reproductive healthcare.”
Researchers can utilise CHLOE to further their understanding of embryo and oocyte development that may enhance current workflows, protocols and practice of reproductive health care.
Eran Eshed, co-founder and CEO of Fairtility, said: “Our mission at Fairtility is to advance and improve reproductive care through CHLOE, our AI powered software platform.
“We promote this in clinical settings through our product offerings and in academic settings to advance the science and understanding of reproductive health.
“We can leverage AI technologies to elevate care in clinics, and ensure researchers continue to advance our understanding to improve patient care in the long term.”
CHLOE is currently being used in tens of clinics around the world. Clinicians utilise CHLOE EQ for automated embryo quality assessment in IVF, CHLOE OQ to support oocyte assessment for fertility preservation, egg donation and in IVF decision making, and CHLOE KPI for clinical and operational performance monitoring.

News
EU healthcare’s gender pay gap hits 19%, WHO report finds

Women in Europe’s health and care sector face a 19 per cent hourly gender pay gap, according to a new World Health Organization (WHO) report.
Women account for 77 per cent of the sector’s workforce, compared with 45 per cent across all other sectors combined, but make up only 55 per cent of its top earners.
The hourly gender pay gap widens at higher wage levels, from 2 per cent among the lowest earners to more than 22 per cent at the top.
The WHO report found that health and care accounts for almost 17 per cent of all women’s employment in its European Region, compared with 5 per cent of men’s employment.
The sector is the fourth-largest employer overall and the single largest employer of women in the region.
Natasha Azzopardi Muscat, director of the Division for Health Systems at WHO Europe, said: “Women make up the majority of the people who keep Europe’s health systems running, yet they’re paid less than their male counterparts, a gap that compounds over a lifelong career.”
The findings follow a pattern seen across the wider labour market, with structural inequality increasing at higher wage and seniority levels.
Globally, women working in health earn an average of 24 per cent less than men, according to the report, a wider gap than in many other industries.
Some of the difference in pay could be explained by work-related factors, including age, education, public or private sector employment and whether people worked full-time or part-time.
After adjusting for those four factors, the hourly pay gap fell from 19 per cent to 6 per cent, while the monthly gap declined from 28 per cent to 10 per cent.
The remaining difference could not be explained by factors measured in the data.
“Most of this gap isn’t down to women working fewer hours, being younger or working in different parts of the sector,” Azzopardi Muscat said.
“It comes down to how the sector values women’s work. Age, education, working hours and public versus private sector employment only helps explain some of it.”
WHO said the findings point to factors including the undervaluation of care work, occupational segregation and potential discrimination in pay-setting practices.
Occupational categories with a higher proportion of women paid less across managerial, professional and technical roles.
Management jobs in health and care employ more women than management roles in other sectors and pay an average of €22 per hour, compared with €24.70 in comparable roles elsewhere.
WHO described the gender pay gap as one of the most persistent forms of labour market inequality. Given the number of women working in health and care, it said the gap could have important economic and social consequences.
The report said the inequality may lead to lower lifetime earnings and pension entitlements, increase women’s risk of poverty, reduce returns to education and undermine sustainable economic growth.
“It means lower pensions, less financial security in older age, and a higher risk of poverty for women who’ve spent their working lives caring for others,” said Azzopardi Muscat.
“This isn’t a coincidence, and it isn’t about qualifications. Women are being paid less for the same work and passed over for the roles that pay more.”
WHO said closing gender pay gaps was both an equity imperative and an investment in a stronger and more sustainable health workforce.
It suggested measures including greater salary transparency, increased female representation in decision-making roles and action to address gender norms and stereotypes.
Ageing
Higher BMI in early adulthood linked to lower breast cancer risk after menopause

Higher BMI at 20 was linked to a lower risk of post-menopausal breast cancer in an analysis of more than 33,000 women.
Lower breast density later in life may partly explain the link between higher body mass index, or BMI, in early adulthood and lower breast cancer risk after menopause.
The findings could help explain why higher body weight in childhood, adolescence and early adulthood appears linked to lower long-term risk, while being overweight in middle age is associated with increased breast cancer risk.
First author Dr Benoit Jauniaux, a surgical trainee in the North-West Deanery, said: “Researchers in previous studies have observed that women with a higher BMI in childhood or their early adulthood appear to have a lower risk of breast cancer after the menopause, but we have not fully understood why.
“This study suggests that downstream changes to breast density may explain a large part of this effect.”
The study was published in the British Journal of Cancer on 17 September 2026 and was supported by the National Institute for Health and Care Research (NIHR) Biomedical Research Centre (BRC): Manchester.
Researchers at The University of Manchester and Manchester University NHS Foundation Trust followed 33,816 women taking part in the UK Predicting Risk of Cancer at Screening (PROCAS) programme for more than a decade.
They recorded 1,261 cases of post-menopausal breast cancer and compared women’s self-reported BMI at age 20 with breast density measurements from routine mammograms.
Breast density refers to the amount of fibrous and glandular tissue compared with fatty tissue in the breast. Women with denser breasts are known to have a higher risk of breast cancer.
Women with a higher BMI at age 20 generally had lower percentage breast density later in life and were less likely to develop post-menopausal breast cancer.
For every five-point increase in BMI at age 20, the risk of developing post-menopausal breast cancer fell by around 15 per cent. Further analysis suggested lower breast density may account for almost 60 per cent of this effect.
Researchers believe the timing of body weight gains may be crucial because women’s breasts are still developing during adolescence and early adulthood, potentially leading to long-term changes in tissue structure.
The study also found that different measures of breast density may reflect different biological pathways linked to breast cancer risk.
One measure, estimating the percentage of dense tissue within the breast, appeared to capture some of the lasting effects associated with higher body weight in early adulthood. Another measure, based on the total volume of glandular tissue, appeared to be more strongly influenced by body weight later in life.
Senior author Professor Andrew Renehan is professor of cancer studies and surgery at The University of Manchester and programme co-lead in the Cancer Prevention and Early Detection Theme at the NIHR BRC: Manchester/
The researcher said: “These findings do not suggest that gaining weight is protective.
“What they offer is further insight into how breast tissue and consequent breast cancer risk may be shaped across a woman’s lifetime, and we want to understand these mechanisms further.
“Maintaining a healthy weight remains important, because excess weight in later adulthood is linked to a higher risk of breast cancer and many other serious diseases.
“But this study adds to growing evidence that exposures during early life can have lasting effects on health decades later.”
Mental health
Neuroscience-backed journaling for women’s mental health

AI-powered journaling app Véa is supporting mental health by helping women to understand their thoughts, triggers and behavioural patterns.
Winner of the Brain and Mental Health Innovation Award at this year’s Femtech World Awards, Véa is designed to address the emotional gap in women’s health technology.
The journal – which has been built by a female team and trained on women’s health papers – tracks inner states, provides personalised insights and somatic practices, and utilises AI to explain complex neuroscience in relatable terms.
Described by its founders as a “protector, seeker, and sculptor”, Véa provides a longitudinal map of women’s emotional journeys, integrating journaling with therapy and both in-person and online community support.
The journal’s goal is to improve women’s mental health without replacing professional care.
Zahra Bhatti, co-founder and CEO and Katrina Zalcmane , co-founder and growth lead speak to Femtech World about the technology, winning a Femtech World Award and their plans for the future.
Women’s health and wellbeing technology has grown so rapidly over the last few years, but is largely focused around physical health. What was the emotional gap that you saw that inspired you to create the journal?
“Women’s health has been focused on reproductive health and physical health, but it is all one ecosystem – it always starts with the mind,” says Zahra.
“Whatever you feel down here, you feel up there too, and the hormones reflect that.
“With Véa, it was actually built from our own personal experience of burnout.
“We wanted to make a space where women could feel safe and were able to reflect what’s on their mind, but also understand their mind the same way that women understand their hormones.
“Women need to understand what happens in our minds. Véa helps women to understand cognitive distortions, why they feel the way they feel, black and white thinking – we wanted to really surface that for them.
“For example, when you’re in your luteal phase, your serotonin levels drop, so that means you’re going to be a bit more nervous.
“You’re going to be more reactive. You’re going to be taking things more deeply, and that’s something that your rational mind wouldn’t normally do if you’re in your ovulation phase.
“So that’s what Véa does – she reflects that back to you, so you understand your body and thought processes.”
Véa describes itself as a journal that’s designed for the female mind. What does that mean in practice, and how does the experience differ from using traditional journaling?
“The majority of our team is female, so Véa has been built from all of our lived experiences, and the AI itself is trained on women’s health papers,” says Katrina.
“It takes into account what having a certain condition means for individuals. For example, if you have endometriosis or PCOS, We’ve trained our AI on womens health data and research, which gets reflected back to the woman in a simple and effective way
“We have a clinical board, who are all also women, who look through the AI and the language. They ensure that all outputs are evidence based, ethical and take into account the various therapies which are proven to work for women.
“We also have somatic practices which are focused on women which we call “rituals”. We have a self-inquiry ritual, a confidence mirror ritual, or we have one of our psychotherapists on the board who does therapy through novels, for example.
“These aim to make you the protagonist of your story.
“Generic journaling apps are one size fits all, but women are not one size fits all, and that’s what we’ve made sure to put in the forefront of Véa.”
Instead of conventional mood tracking, you are focused on the inner states of women. How do you develop that approach, and what kind of insights has it revealed about how women reflect on their emotions?
Katrina says: “Mood plays a part in our inner state and Véa checks in on that.
“It allows you to have a journey across time. For example, on a good day, maybe their “protector” aspect is good at setting boundaries, but on a bad day, it could be really closed off.
“It’s a richer approach, and these inner states are tied to specific prompts which are then linked in the journaling.”
“As women, we are fluid,” adds Zahra.
“We are not one entity.
“For example, you might be in a state where you’re really overthinking, but actually, you’re seeking new perspectives, and that’s why within Véa, the inner state is called a “seeker”.
“When you converse with Véa in your seeker mode, she will challenge you in a Socratic way.
“However, the next day, you might be a “protector”, and then Véa will adjust her voice for a reflective and exploratory tone compared to when you were a seeker.
“Another state which I love is the “sculptor” which is when you’re feeling confident.
“When you’re a sculptor, Véa will talk about how you can be creative, asking questions such as ‘what did you create today?’ ‘How did that make you feel?’ and ‘How would you describe that if you could put a shape to this color, this feeling?’, for example.
“Véa goes into all of these different modes, and it builds a longitudinal map of the woman as well. So, throughout weeks, months and years, you can see how you’ve changed across time.”
How did you approach designing an AI companion that feels supportive without replacing human connection or professional care?
“For the past six years, I’ve been a product manager. So I’ve seen how all of these web apps and applications have been built, and I’ve worked quite deeply with AI so I knew what was missing and like what women truly needed,” says Zahra.
“The key thing for us is that we want to bring “URL to IRL” [in real life].
“We have a community that goes alongside Véa. This includes a WhatsApp community and events.
“We turn the rituals inside Véa into in-person workshops at our events with our clinical board and with professionals in the space.
“We are not neuroscientists, but there are neuroscientists who have helped us build the app, and we make sure that AI is there to support you, but AI will never replace that human touch.
“That’s something that’s very close to us, and we want to make sure we connect people together and help people reflect in a safe space.
“As well as AI, there is the option to talk to the clinical board, to use their rituals, to reflect with the community, and go to our events.”
Katrina adds: “The key is that whatever the touch point is, whether it’s the app or it is an event or even our online community, we don’t want women to feel alone. We want them to feel together, grow together, and process together.”
People may often start journaling with good intentions, but struggle to stick with the practice. What have you learned about building habits and how those insights have shaped the experience of your product?
Zahra says: “I think everyone wants to gamify things – what helps us is the community aspect.
“We’ve created a tribe through the community, and because it’s so hyper personalised, you help shape the app, the app doesn’t shape you. You have full control, which makes people want to come back.
“Véa remembers what you said yesterday as well as six weeks ago, and she will surface that.
“We do have “streaks”, but our streaks are very gentle – every time you get a streak, you get a neuroscience fact along with it.
“Something else we have built in that helps retention is “breakthroughs”. When Véa detects a shift in language, and will highlight, for example, that you have shifted from overthinking to certainty.”
“I think people are sick of data, they’re sick of data that they can’t interpret from. Véa interprets for you.
“Soon we will evolve even more and add more features such as cycle tracking, wearable tracking and hormone tracking, to build out that ecosystem.”
What does success look like for Véa and how do you see the app and the community evolving as you move forward?
“We want to launch across so many different markets. Our next target is the US,” explains Katrina.
“We want to bring our events over there as well. We do a lot of corporate events too. We have one with NatWest coming up – we know that work stress is a big thing, especially amongst females.
“I think there’s a real space for that in the corporate world, so that’s one of our key focuses.”
Zahra adds: “Growing in markets and keeping going with our communities. We have just launched a supper club which sold out in three days in Manchester, which is absolutely amazing. We’re doing some in London and Amsterdam as well in the next few months. We are focused on growth, growing our board as well, and keeping the female mind at the center.”
What does it mean to win the Femtech World Award?
Katrina says: “When you are so passionate and truly believe in something, you do it for that reason, but that external validation of seeing that it also matters for others in the wider space means so much.
“Especially, in Femtech – it is a whole category that has been growing, but when it comes to funding and recognising women’s issues, there is still a lot of awareness that needs to be raised.
“Being recognised gives us that fuel to continue and drive forward, and that it really does matter.”
“We want to be at the forefront of women’s mental wellness as a whole, and have put many sleepless nights into developing the app, so it is a big testament to that,” adds Zahra.
Menopause1 week agoMenopause may not explain rising heart condition in women – study
Entrepreneur2 weeks agoLast chance to save on Women’s Health Week and Women’s Sport Summit: Early Bird pricing ends 11 September
Fertility2 weeks agoParacetamol use may impact future fertility, studies suggest
Insight1 week agoWomen with birth trauma face 2.5x higher healthcare costs – study
Menopause2 weeks agoCancer drug could tackle osteoporosis menopause weight gain
pain conditions6 days agoMedical cannabis may improve endometriosis symptoms – study
Cancer1 week agoStudy could explain why obesity is a breast cancer risk factor
Diagnosis2 weeks agoFDA approves AstraZeneca breast cancer drug











Pingback: Study shows CHLOE AI’s role in advancing reproductive health research - Fairtility