Insight
Precision oncology is here — So why are so many breast cancer treatments still a gamble?

By OncoGenomX, Allschwil, Switzerland
When it comes to breast cancer treatment, one truth remains painfully clear: despite decades of progress we still cannot answer the question which treatment(s) a tumour will respond to.
At OncoGenomX, we think it’s time to change that.
We now have tools that allow us to look inside a tumour, understand how it behaves, and predict what treatments will work best—not just for a cancer subtype, but for an individual tumour, with its unique biology.
It’s called Precision Oncology, and it’s one of the most promising frontiers in cancer care. But right now, its full potential is still out of reach for too many patients.
So why the gap?
The Promise: Personalised Treatment That Works the First Time
The dream of precision medicine is simple: treat the person, not just the disease.
In breast cancer, doctors already use some personalised tools. For example, hormone receptor tests help decide whether a patient should receive endocrine therapy.
Genetic tests like Oncotype DXTM or MammaprintTM can help determine whether chemotherapy is needed. These are great first steps.
But here’s the problem: these tools don’t go far enough. They often tell us what could work, but not what will work. Many patients are still treated based on probabilities and population averages, not precise predictions tailored to their specific tumour.
The result? Too many women receive therapies that don’t work—or stop working quickly. Some get treatments that are too aggressive. Others don’t get enough.
The Reality: Cancer Is Chaotic
Part of the reason breast cancer is so difficult to treat is that no two tumours are alike. Even within a single tumour, cells can behave very differently.
Scientists call this “coordinated chaos.” It means that a treatment might hit some parts of a tumour—but miss others entirely. It also means that two women with the “same” diagnosis may need completely different treatments.
In one major study, only about 1 in 5 patients with advanced cancer actually received all the treatments they were genetically eligible for. Even more worrying: in half of the cases, at least one drug in the treatment plan was likely ineffective.
This isn’t just a medical issue—it’s an economic one. Unmatched or suboptimal therapies drive up costs, delay results, and cause unnecessary side effects.
Precision isn’t just better for patients—it’s better for health systems too.
The Breakthrough: Predicting Treatment Response
At OncoGenomX, we believe the missing link is prediction.
We need tools that can do more than classify tumours or identify potential drug targets. We need models that predict how a specific tumour will respond to tailor-made treatment combination.
That’s why we created PredictionStar™, a clinical decision-support tool designed to help oncologists choose optimal treatment combinations, earlier.
It works by analysing real patient data, tumour biology, and how different therapies interact—so doctors can plan treatment combinations based on what’s most likely to work in concert.
In hypothesis generation studies, we’ve seen a 15–22 per cent improvement in treatment success rates—especially beyond first-line therapy. And when treatments work better, patients do better: survival improves, side effects decrease, and costs drop.
The Future: Smarter, More Human-Centered Oncology
We’re not claiming to cure cancer. But we do believe that better decisions lead to better outcomes.
Our goal is to help oncologists move away from treatment decisions based on probabilities and population averages towards truly rational and individualised treatment planning. That means:
Understanding which therapies are likely to work before trying them
Combining treatments in ways that maximise long-term benefit
Matching each patient to the right combination—any treatment line
This is especially important for women’s health.
Breast cancer is the most common cancer among women worldwide. Yet many women still receive treatments that don’t reflect the full complexity of their disease—or the sophistication of today’s science.
Why It Matters for FemTech
At its core, precision oncology is a FemTech issue. It’s about using technology, data, and science to improve women’s lives.
Breast cancer doesn’t affect all women equally. Outcomes vary by age, race, income, and geography.
That’s why we must ensure that the tools of precision oncology are accessible, equitable, and informed by real-world data from all patients—not just clinical trial populations.
By combining human data, artificial intelligence, and biology, we can move toward a future where every woman receives the best possible care, from the very first treatment.
A Question Worth Asking
If there were a tool with the potential to help doctors select the right treatment combination for a patient’s tumour—based on predictive information—wouldn’t we want them to use it?
At OncoGenomX, we think the answer is clear.
The future of breast cancer care is personal. Let’s make it predictable, too.
Find out more about OncoGenomX at oncogenomx.ch
Insight
Women urged to be wary of menopause misinformation on social media

Women are being urged to seek evidence-based advice and avoid menopause misinformation shared on social media.
A seminar co-hosted by the World Health Organization (WHO) mainly examined what is known about the cognitive effects of menopause and current research in the field worldwide.
Dr Nicole Jaff, a South African academic and certified menopause practitioner, said research into menopause and its effects was now at a peak.
She said: “There’s a lot of information out there.
“But I would say please look for the evidence-based information, not for the influencers and the misinformation, but those who are giving guidelines, who are giving information.”
Jaff highlighted research into cognitive changes during menopause and how some women experience brain fog, a term for difficulties with memory, concentration and clear thinking.
She said: “I’m very excited about the non-hormonal treatments that are now available, especially for women who could never take hormone therapy because of breast cancers and various cancers, who can now take it.
“I’m extremely excited about people who are standing up for evidence-based medicine, for science, who are actually fighting back against a lot of the social media and influencers who are not giving evidence-based information and making life very difficult for women because they think they should be forever young or buying this or buying that.”
Jaff advised women and healthcare workers to read new guidelines recently issued by the International Menopause Society. They are available free to download from its website.
The seminar also heard from Professor Aimee Spector, professor of clinical psychology of ageing at University College London.
She raised similar concerns about misinformation, particularly claims linking hormone replacement therapy, known as HRT, to dementia. Some claims suggest HRT reduces dementia risk, while others suggest it increases the risk.
Spector said: “I think there’s also lots of misinformation.
“And I think that there’s huge variations in how even professionals and doctors interpret this information.”
She was part of an international research team commissioned by the WHO last year to assess published studies on the issue.
The institutions involved also included the Global Brain Health Institute at Trinity College Dublin.
Spector said: “The first thing to say is that the quality of evidence was very low.
“Nine out of the 10 studies we looked at were observational, which means that you’re observing patterns over time. But you don’t necessarily know whether that’s due to the hormone therapy or not.
“Our overall recommendation was that there’s insufficient evidence for menopause hormone therapy in terms of either increasing or reducing the risk of dementia. In other words, we don’t know either way.”
Spector said women should therefore decide whether to use HRT to treat menopause symptoms rather than based on concerns about dementia.
She said: “It’s recommended for menopause symptoms, but it’s not recommended to reduce dementia. And I think a lot of people are saying that.”
The Menopause on the Brain webinar was part of an ongoing series hosted by the WHO and other global health agencies.
Insight
Endometriosis musical set for Edinburgh Fringe stage

An endometriosis musical by two US writers will debut at the Edinburgh Festival Fringe in August.
“Endometriosis: The Musical” follows Jane, a woman trying to discover why she is living with chronic pain.
Maria Bartholdi and Kristin Stowell first developed the production for the 2022 Minnesota Fringe Festival.
The full show premiered at Theater in the Round in Minneapolis in 2025.
Stowell said the play drew on personal experience, although neither writer realised it at the time.
“So it’s like my goal to let women see themselves in this who are dealing with this and have a question they can bring back to their doctor,” she said.
“Like, could it be endometriosis?”
Bartholdi said she did not realise she might have the condition herself until after the play premiered.
“This show helped diagnose me, which I think is just one of the miraculous things that we hope this the show does for other people as well,” Bartholdi said.
Dr Wendy VanBuren, a radiologist at Mayo Clinic in Rochester, said she was a fan of the musical and its role in raising awareness of a common but underdiagnosed disease.
“Cells that are similar to but not identical to the cells that comprise the lining of the uterus, the inside of the uterus, are located outside the uterus,” said VanBuren.
“When they’re outside the uterus, there isn’t the right environment to deal with that. So basically, what you get is bleeding, and then you get inflammation.”
Roughly one in seven women live with the disease, and receiving a diagnosis can take nearly a decade.
Insight
Johnson & Johnson offers to pay US$5.5bn to settle talc cancer lawsuits

Johnson & Johnson has offered an estimated US$5.5bn settlement covering about 76,000 claims that its talc products caused ovarian cancer.
The proposed agreement could end a contentious legal dispute over the company’s baby powder and other talc-based products that has lasted around a decade.
Johnson & Johnson said the settlement covers claims consolidated in a federal court in New Jersey and related cases in state court.
The claims represent nearly all the remaining talc cases against the US multinational, according to the company.
Johnson & Johnson has previously settled most claims alleging that its talc contained asbestos and caused mesothelioma.
Mesothelioma is a rare cancer affecting the lining of organs, most commonly the lungs, and is usually linked to asbestos exposure.
Law firms representing claimants confirmed the proposed deal, describing it as a good resolution after around 10 years of litigation.
The agreement must be accepted by 95 per cent of ovarian cancer claimants in state or federal court before it becomes final.
Erik Haas, vice-president of litigation at Johnson & Johnson, said the claims were “meritless” and that the company was willing to settle to bring the litigation to a close.
“While we are confident the company would have ultimately prevailed with further litigation, as it has in the vast majority of cases tried to date, this resolution allows the company to put this matter behind it and remain focused on its mission to develop medicines and devices that save lives,” Haas said.
The company expects to pay US$3bn in 2027, with further payments due in 2028.
The deal could be worth more, depending on how many people take part in the settlement.
Chris Seeger, a lawyer representing around 2,500 clients with talc claims who helped negotiate the agreement, said Johnson & Johnson could ultimately pay US$7bn or more.
The settlement assigns specific values to qualifying ovarian cancer claims but does not cap the company’s total payout.
“We got a fair settlement, and our clients are going to be happy with it,” Seeger said.
Johnson & Johnson reached the agreement after a series of court victories, including wins in individual trials and successful efforts to disqualify claimants’ lawyers from the litigation.
The company also secured court rulings against experts used by claimants to support their cases.
A federal judge last week questioned whether individual claimants could prove that talc had specifically caused their ovarian cancer.
Johnson & Johnson has consistently denied that its talc products caused cancer, maintaining that the products were safe and did not contain asbestos.
The company stopped selling talc-based baby powder in the US in 2020 and switched to a cornstarch-based product.
Litigation resumed in March 2025 after being paused for more than three years while Johnson & Johnson pursued a bankruptcy strategy known as the “Texas two step”.
The company filed three bankruptcies through a shell-company subsidiary in an attempt to settle the cases. Each bankruptcy was dismissed.
Before the bankruptcy attempts, Johnson & Johnson had a mixed record in talc trials.
These included a multibillion-dollar verdict for 22 women who said baby powder caused their ovarian cancer, alongside trials won by Johnson & Johnson and other verdicts later reduced on appeal.
Unlike the proposed bankruptcy settlements, the latest agreement applies only to existing claims and does not cover future lawsuits.
Seeger said excluding future claims made more money available for current claimants than the bankruptcy proposal and would allow all claims to be paid within 18 months rather than over more than a decade.
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