Pregnancy
Endometriosis infertility linked to higher pregnancy rates

Women with infertility linked to endometriosis are four times more likely to become pregnant than those with infertility from other causes, a 30-year study has found.
The findings analysed health records from more than four million women in England.
The data showed that 40.5 per cent of those diagnosed with endometriosis had at least one pregnancy during the study period.
Dr Lucky Saraswat, from the Aberdeen Centre of Women’s Health Research at the University of Aberdeen, who led the study, said: “Endometriosis can vary in how it affects fertility.
“Women with milder forms may retain good reproductive potential, especially if the condition is diagnosed and managed early.
“There’s also moderate-quality evidence suggesting that laparoscopic surgery can improve pregnancy rates in some with endometriosis.”
She added that women with endometriosis may be more likely to seek fertility help earlier due to greater awareness of the condition’s impact.
Researchers from the University of Aberdeen and the University of Edinburgh conducted the study as part of the EU-funded FEMaLe (Finding Endometriosis through Machine Learning) consortium.
It is the largest and longest population-based study of its kind, covering linked primary care, secondary care and maternity records between 1991 and 2020.
Of the 4,041,770 women aged 13 to 50 who attended primary care with infertility or symptoms of endometriosis, 111,197 had a surgically confirmed diagnosis of endometriosis via laparoscopy or laparotomy – procedures used to examine the abdomen and pelvic organs.
The overall prevalence of female infertility was 48.9 per 1,000 women, with the highest rates among those aged 30 to 39.
Among women with infertility, 6.1 per cent – 14,904 women – had surgically confirmed endometriosis.
Of these, 57.4 per cent had experienced infertility before their diagnosis, highlighting ongoing delays in recognising and diagnosing the condition.
The study reaffirmed that women with infertility were more than twice as likely to be diagnosed with endometriosis compared with those without infertility.
However, those with endometriosis-associated infertility had significantly higher pregnancy rates than women with infertility caused by ovulatory dysfunction, tubal factors or unexplained infertility.
Saraswat, said: “While fertility remains multifactorial, with factors such as age playing a significant role, our findings offer robust, evidence-based data that can significantly enhance fertility counselling for women newly diagnosed with endometriosis – including information on the likelihood of infertility, overall pregnancy rates and outcomes, and how those outcomes compare to other causes of infertility.
“These insights can empower women to make informed reproductive decisions.
“They also provide a strong foundation for future research into how factors such as disease stage, site, surgical treatment and use of assisted reproduction influence pregnancy outcomes in women with endometriosis.”
Professor Dr Anis Feki, chair-elect of ESHRE, said: “This study shows that women with endometriosis-related infertility are significantly more likely to conceive than those with other infertility causes.
“These findings provide valuable reassurance for patients and underscore the importance of early diagnosis and tailored treatment strategies.”
Pregnancy
Pregnant women told to avoid runny eggs amid salmonella outbreak

Pregnant women are being advised to avoid runny or under-cooked eggs when eating out amid a developing salmonella outbreak.
The advice also applies to freshly made products that may contain uncooked eggs, including mayonnaise, soufflé and hollandaise sauce.
The FSA said well-cooked eggs served in restaurants, cafés and takeaways remain safe to eat.
The warning follows the UK Health Security Agency declaring a national outbreak of salmonella food poisoning after one person died and hundreds more fell ill.
Imported eggs or dishes containing them are thought to be behind the outbreak.
FSA chief scientific adviser Ian Young said: “If people are eating out or consuming eggs or egg-containing products from cafes and restaurants then for those people in particular who are young, elderly, pregnant or vulnerable, it’s important to make sure that any eggs or egg products that you consume in those settings have been very well cooked.”
He described the outbreak as “unusually large and rapidly increasing”, adding that “people need to be careful”.
The FSA said British eggs bought from supermarkets are not linked to the current outbreak because chickens bred in the UK are vaccinated against common strains of salmonella.
“There is no link to those eggs to this current outbreak,” Young said.
Mark Williams, chief executive of the British Egg Industry Council, said British eggs were safe to eat when runny, including for vulnerable people, and were widely available in restaurants and cafés.
“Customers who want to enjoy a runny egg should simply ask whether British Lion eggs are being used,” he said.
More than 200 cases in the UK have been linked to the outbreak, with the majority across England.
Genetic testing suggests the infections are part of the same outbreak and show similarities with previous outbreaks involving imported eggs.
Investigations into individual cases also suggest the eateries involved were buying eggs from abroad.
Salmonella are a family of bacteria that typically live harmlessly in the digestive systems of animals including cattle, pigs and chickens, which is why eggs and poultry are among foods commonly associated with infection.
People can become infected by eating contaminated food that has not been properly cooked, through cross-contamination between raw and cooked food or by coming into contact with infected animals.
Symptoms can include stomach cramps, diarrhoea, vomiting and fever.
Most people recover without further treatment, but older people, babies and people with weakened immune systems are at greatest risk of severe illness.
Hospital treatment with fluids and, in some cases, antibiotics may be needed for severe infections.
People who are concerned are being advised to contact their GP or out-of-hours service in the first instance.
Pregnancy
Women with multiple long-term conditions face increased pregnancy risks – study

Women entering pregnancy with multiple conditions face a 20 per cent higher miscarriage risk and around four times the risk of anxiety and depression, new research has revealed.
The observational study found women with two or more pre-existing long-term physical or mental health conditions also had a 69 per cent higher risk of severe nausea and vomiting.
They had more than double the risk of venous thromboembolism, when a blood clot forms inside a vein, and a 42 per cent higher risk of pre-eclampsia, a pregnancy complication involving high blood pressure.
Dr Steven Wambua, research fellow in health data science at King’s College London and joint first author, said: “Maternity care is still largely organised around single health conditions, but one in five women now enters pregnancy with two or more.
“By harmonising five datasets covering all four UK nations, we could show consistently and across a much broader range of outcomes than before, that these women face higher risks and that risk climbs with every additional condition.”
Researchers from King’s College London, Queen’s University Belfast, Bristol NHS Foundation Trust, the University of Birmingham, Swansea University and the University of St Andrews analysed more than 2.2m pregnancies and birth events recorded between 2000 and 2022.
The data came from five datasets covering England, Scotland, Wales and Northern Ireland.
Around one in five pregnant women in the UK live with multiple long-term conditions, but their combined impact on pregnancy is poorly understood.
The study found risks rose with each additional condition. Women with three or more conditions had more than three-and-a-half times the risk of venous thromboembolism compared with women without long-term health conditions.
Women with multiple conditions also had a 32 per cent higher risk of placental abruption, when the placenta separates from the womb before birth, and a 26 per cent higher risk of gestational diabetes.
The researchers said maternity care pathways vary considerably and, where they exist, are often organised around individual conditions.
They said the findings highlight a need to restructure these pathways to address the complex needs of women living with multiple conditions.
Professor Krishnarajah Nirantharakumar, clinical professor of public health and health data science at King’s College London, MuM-PreDiCT principal investigator and joint senior author, said: “These findings make a strong case for recognising multiple long-term conditions as a marker of antenatal risk in its own right.
“That means identifying these women at maternity booking, assessing physical and mental health needs together, and joining up obstetric, primary care and mental health services around them.
“The near four-fold risk of antenatal anxiety and depression is particularly striking, and points to perinatal mental health support as an urgent priority.
Dr Kelly-Ann Eastwood of Bristol NHS Foundation Trust and Queen’s University Belfast, joint senior author, added: “Our results help define the urgent clinical challenges facing both women entering pregnancy with multiple long-term conditions, and clinicians caring for them across the UK.
“Supporting recommendations from recent national maternity and neonatal investigation reports, there is a critical need to address healthcare inequalities, and improve support for women with pre-existing mental health conditions.
“These findings highlight the pressing need to restructure existing maternity services to improve antenatal outcomes.
The authors cautioned that, because the study used routinely collected health records, some conditions and outcomes may have been under-recorded or recorded inconsistently.
Further work by the MuM-PReDiCT consortium will examine birth and child outcomes and identify which combinations of long-term conditions carry the greatest risk.
Pregnancy
Climbing during pregnancy may be safer than long assumed, study finds

Climbing during the third trimester was not linked to higher rates of self-reported pregnancy complications in a global study.
The findings provide direct evidence on an activity pregnant women have traditionally been advised to avoid because of concerns about falls.
Researchers surveyed 692 people about climbing during pregnancy, falls, maternal and baby health outcomes and their return to the activity after giving birth.
The study recorded almost 64,000 hours of climbing among participants.
During that time, participants reported 155 “hard falls”, defined as falls or catches forceful enough to be remembered or cause concern.
The rate of adverse clinical events, meaning negative medical outcomes affecting the pregnancy or baby, was 0.03 per 1,000 hours of climbing exposure. All babies in the study were born live.
Researchers found no significant difference in pregnancy or foetal health outcomes between participants who stopped climbing at or before 27 weeks and those who continued beyond that point.
The findings suggest continuing the activity into the third trimester was not associated with increased self-reported complications among those surveyed.
The survey also found 96 per cent of participants said that, despite concerns about climbing while pregnant, they felt “happy” or “very happy” that they had continued.
Margie Davenport, professor in the Faculty of Kinesiology, Sport, and Recreation and lead author of the study, said the preliminary findings challenge an assumption about maternal exercise that had been based on opinion rather than research.
She said: “For decades we have restricted pregnant women from activities like climbing due to concern for their health and the health of the baby, but our evidence suggests it’s beneficial for both mental and physical health.”
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