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‘Devastating’ fault at London clinic may have damaged eggs of more than 100 women

Patients have only recently been told their eggs and embryos may not survive the thawing process if they were frozen with the faulty solution

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More than 100 women who had their eggs frozen at a leading NHS clinic have been told that they may have been damaged due to a fault in the freezing process.

The assisted conception unit at Guy’s hospital in London said it may have inadvertently used some bottles of a faulty freezing solution in September and October 2022. However, it said it did not know the liquid was defective at the time.

Many of the 136 women affected have subsequently had cancer treatment since having their eggs or embryos frozen, which may have left them infertile, The Times reported.

The patients have only recently been told their eggs and embryos may not survive the thawing process if they were frozen with the faulty solution.

The fertility regulator, the Human Fertilisation and Embryology Authority (HFEA), is investigating.

It said a safety notice about the faulty freezing solution was issued by the authority to all clinics in February last year. However, this was several months after bottles from a faulty batch were used at Guy’s hospital’s assisted conception unit.

HFEA described the investigation at Guy’s hospital as “ongoing”, adding that it would take “any further action required”.

The regulator said that faulty egg-freezing products had also affected Jessop Fertility in Sheffield, but it said it was satisfied that Jessop “undertook a thorough investigation when they first became aware of the issue and contacted and supported any patient affected”.

“The HFEA can confirm that this issue is limited to two clinics in the UK: Guy’s and St Thomas’ Assisted Conception Unit, London and Jessop Fertility, Sheffield,” said Rachel Cutting, director of compliance and information at the HFEA, in a statement.

“Our ongoing investigation only relates to Guy’s as we are satisfied that Jessop’s undertook a thorough investigation when they first became aware of the issue and contacted and supported any patient affected.

“The company supplying the product directly to clinics will know exactly where it’s gone through their traceability processes. The company is also obliged to report any problems to the MHRA.”

“Any patients likely to have been affected will have been notified by their clinic. We hope this provides reassurance to anyone concerned.

“Fertility treatment in the UK is generally very safe. Our most recent report shows that out of the almost 100,000 treatment and storage cycles which took place in 2022/23, more than 99 per cent were conducted without any incidents occurring.”

Dr Piraye Yurttas Beim, researcher in molecular biology and embryology and founder of Celmatix, told Femtech World: “This is a reminder that the safest place for a woman’s eggs is in her own ovaries and not a freezer.

“Women lose their ovaries far too frequently due to a lack of diagnostics that would allow earlier detection of ovarian cancer and also due to ovarian damage from chemotherapy.

“Creating a new standard of care that protects ovarian function for women undergoing cancer treatment is a big focus for us at Celmatix. These stories are both heartbreaking and also a reminder of why we come to work everyday.”

Dr Cristina Hickman, a consultant clinical embryologist, lecturer at Imperial College London and co-founder of Ovom Care, said: “As an embryologist, I was devastated to learn of the unfortunate incident that has come to light at Guy’s hospital.

“Despite our best efforts to uphold the highest standards of care, incidents do occur, even if rarely. These errors, while rare, profoundly impact patients and the dedicated embryologists who strive to fulfil the shared goal of helping families conceive.

“It’s devastating news for those affected and they have our full support and we should wait to learn more from the professional team investigating this incident.

“But we must also recognise the tireless efforts of embryologists, who bear the weight of this responsibility and work diligently to maintain a low error rate.

“As fertility professionals, it’s our duty to utilise the most advanced tools available to minimise any risks that could affect our patients’ chances of having a baby. By embracing innovation and continually improving our practices, we can ensure that incidents like these become even rarer in the future.”

Sarah Norcross, director of the Progress Educational Trust (PET), commented: “It will be distressing for women with frozen eggs to learn that, due to problems outside their control, their eggs may not survive the thawing process.

 “When a woman freezes her eggs, time is of the essence. In all cases, the quality of eggs declines upon reaching a certain age. Additionally, in cases where women are freezing eggs for medical reasons – for example, imminent cancer treatment – they will not want their treatment to be delayed.

 “If women affected by this incident have undergone medical treatment which has compromised their fertility, then their opportunity to have a biologically related child may have been lost.

“If women affected by this incident had sought to extend their reproductive choices by freezing their eggs, then they too may have lost their best opportunity to have a family, if the quality of their eggs has declined during the period that has elapsed.”

She added: “We still do not know all the details of why this incident occurred. Hopefully, further details will be forthcoming. What does seem clear is that there was an appalling delay of around a year between this problem being known about, and affected patients being notified. Apparently, there are also some patients with frozen embryos who are similarly affected.

“We need to understand more about what precisely has gone wrong, and what the relevant regulators – including the HFEA and the MHRA – are doing about it. We also need reassurance, from regulators and clinics alike, that processes are in place to notify patients in a timely way when things go wrong.”

Becky Kearns, chief executive at Fertility Network UK, told Femtech World: “We are heartbroken to hear of the news that patients have potentially lost precious eggs and embryos.

“We want to reassure patients that incidents like this are extremely rare in the UK. We know that for many people, particularly those whose fertility has been impacted by cancer treatment, egg freezing can be a lifeline and can often be the difference between being able to have the family they have longed for.”

“As the national fertility charity, we urge anyone who may have been affected by this news, directly or indirectly, to please reach out to us for support. You are not alone.”

Wellness

Ovum secures US$4m in seed funding

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Women’s health startup Ovum has raised US$4m in seed funding to develop its AI health journal and expand research using women’s health data.

The round valued the Melbourne startup at US$18m.

Ovum plans to use the funding to develop its artificial intelligence technology and longitudinal datasets, which track health information over time to reveal changes and patterns.

The AI captures symptoms, lifestyle factors, biometric measurements, reproductive health stages, medication, appointments and medical reports.

It uses this information to identify health patterns and create summaries and questions for medical appointments.

Ovum previously raised US$1.7m in pre-seed funding in February 2025 before launching its health journal app in August that year.

Since then, the company says the app has grown by 30 per cent month on month and recorded more than 20,000 downloads.

It has captured 57,000 health data insights and hosted more than 107,000 AI health conversations involving women aged between 15 and 84.

Founder Dr Ariella Heffernan-Marks developed the idea while she was a third-year medical student experiencing chronic migraines and was told that her pain was caused by anxiety.

The company describes the resulting women’s health journal as combining technology and clinical research to make health information more actionable and equitable for women.

Heffernan-Marks said: “I’ve sat on both sides of the desk, as a patient and as a doctor, and that’s why this mission matters so much to me.

“For too long, women have had to navigate healthcare systems that were not designed around their lived experiences or backed by sufficient female health data. Ovum exists to help women better understand their bodies, advocate for themselves with confidence, and contribute to research that improves care for future generations.”

Private health insurer Medibank is an Ovum partner, alongside Fernwood Fitness, Sweat and Menopause Friendly Australia.

Australian Red Cross Lifeblood is also involved in a pilot examining productivity losses caused by women reducing their working hours or leaving employment for health reasons.

Earlier in 2026, Ovum launched clinical trials with St George Hospital and the Royal Hospital for Women to assess AI as a preventative health tool for women.

The research is examining how women currently manage their health, which digital tools they use and whether AI could support health confidence, self-advocacy and continuity of care.

Continuity of care means receiving connected and consistent support across different appointments, healthcare professionals and services.

The funding round was led by Admiralty Capital Group, with participation from Antler, Giant Leap, Aviron Investments, Foggy Valley Aotearoa, Brisbane Angels and Think & Grow.

Existing investor LaunchVic, which is due to merge with Breakthrough Victoria, also participated through its Alice Anderson Fund, which focuses on female founders.

Amanda Andriano, founding partner at Admiralty Capital Group, said the gender health gap was a problem that should not be tolerated.

She said: “Ovum combines mission, market timing and technical capability with an exceptional founder uniquely positioned to lead this movement, and we believe that creates the foundation for a company of global significance.”

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Diagnosis

Women with endometriosis more likely to be diagnosed with STIs – study

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Women with endometriosis or painful periods were four to five times more likely to receive an STI diagnosis, a large Japanese study found.

Endometriosis occurs when tissue similar to the lining of the womb grows outside the womb. Although not strictly a menstrual disorder, it can cause pain, irregular periods and infertility.

The study was led by researchers at the University of Yamanashi and funded by Rohto Pharmaceutical Co.

The analysis examined health insurance claims from more than 3.4m women aged 40 or younger who had at least one healthcare visit during 2023.

Around 260,000 women, or 7.5 per cent of those included, had been diagnosed with endometriosis, dysmenorrhoea or both.

Dysmenorrhoea is the medical term for painful periods or menstrual cramps.

Women with endometriosis, dysmenorrhoea or both were four to five times more likely to have a recorded diagnosis of a sexually transmitted infection, or STI, than women without the conditions.

Diagnoses were significantly more common across every category examined, including chlamydia, gonorrhoea, trichomoniasis, genital herpes and other STIs.

Chlamydia was recorded in 3.5 per cent of women with menstruation-related conditions, compared with 0.7 per cent of those without them.

This represented a fivefold increase and the largest difference in prevalence between the two groups.

Gonorrhoea was diagnosed in 0.9 per cent of women with the conditions, compared with 0.2 per cent of those without them, also representing an increase of about five times.

Trichomoniasis, genital herpes and other STIs were diagnosed four to five times more often in women with endometriosis, dysmenorrhoea or both.

Women with endometriosis had the highest STI diagnosis rates overall.

Almost five per cent had a recorded chlamydia diagnosis, making it the most common STI in this group and more than seven times as prevalent as among women without menstruation-related conditions.

Women with dysmenorrhoea also had higher diagnosis rates for every STI included in the analysis.

The study found little evidence that hormonal treatments, including low-dose oestrogen-progestin therapy, affected STI diagnosis rates.

Differences between women who used hormonal treatment and those who did not were generally less than one percentage point.

Researchers suggested several possible explanations for the association between menstruation-related conditions and STI diagnoses.

One likely explanation is that women with endometriosis and dysmenorrhoea attend healthcare appointments more often.

As many STIs cause only mild symptoms, women seeking care more frequently for these conditions may be more likely to have infections detected.

Biological and behavioural factors may also play a part.

Menstruation-related conditions, particularly endometriosis, are associated with inflammation, pain during sex and sexual dysfunction, which could influence contraceptive practices and susceptibility to infection.

However, the authors said these possible explanations “remain speculative.”

They cautioned that differences in healthcare-seeking behaviour make it difficult to determine whether women with menstruation-related conditions acquire more infections or are simply more likely to receive a diagnosis.

The authors concluded that the findings underline the importance of STI screening and reproductive health education for women with endometriosis or painful periods.

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Menopause

Statins may worsen menopause symptoms, study suggess

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Statins have been linked to more severe menopause symptoms and a higher risk of muscle loss in postmenopausal women, a study suggests.

The medicines are among the most widely prescribed in the world, with strong evidence supporting their use to lower cholesterol and reduce cardiovascular risk.

However, some recognised side effects may resemble symptoms associated with menopause, raising questions about how the two could interact.

The US Food and Drug Administration has flagged potential adverse effects linked to statin treatment, some of which overlap with menopausal complaints.

Researchers examined data from 1,184 postmenopausal women across nine Latin American countries, assessing menopausal symptoms, sarcopenia risk and cognitive function.

They compared women taking statins with non-users after accounting for factors including age and body weight.

As the study was cross-sectional, meaning it examined information collected at one point in time, it could identify associations but could not prove that statins caused the outcomes.

Women taking statins were 56 per cent more likely to have severe menopausal symptoms than those who were not using the medicines.

The difference remained after researchers accounted for other variables.

Statin users were also 65 per cent more likely to be at risk of sarcopenia.

Sarcopenia is the gradual loss of muscle mass and physical function, which tends to accelerate after menopause.

Declining oestrogen levels already make muscle loss a concern at this stage of life. It is linked to a higher risk of falls, fractures and reduced quality of life.

Musculoskeletal symptoms were reported by 53.1 per cent of statin users, compared with 33.9 per cent of non-users.

Researchers said this was separate from the finding on sarcopenia risk and may point to a wider pattern of physical discomfort among women taking the medicines.

Women taking statins also recorded slightly lower scores in tests of delayed memory recall and visuospatial function.

Visuospatial function is the ability to understand the position of objects and their relationship to one another.

The study found no overall association between statin use and mild cognitive impairment, so the differences in individual tests are early signals rather than firm conclusions.

Researchers said effects associated with statins may overlap with menopausal symptoms and add to the overall symptom burden during midlife.

This means symptoms attributed to menopause and possible statin side effects may look similar and, in some cases, could compound one another.

Further research is needed to separate the possible effects of the medicines from symptoms linked to menopause.

The findings are not a reason for women to stop taking statins.

Their cardiovascular benefits are well established, and stopping treatment without medical guidance can carry serious risks.

The study provides more information about what statin treatment may mean specifically for postmenopausal women, who have historically been under-represented in cardiovascular research.

Women who notice more severe menopausal symptoms or changes in muscle strength or physical function while taking statins should discuss them with a doctor.

A healthcare professional may consider whether the symptoms could be related to the medication and whether screening for muscle loss is appropriate.

They may also review whether the current statin remains the most suitable option, as different statins can have different side-effect profiles.

Resistance training and consuming enough protein are well-supported ways to help preserve muscle mass during midlife.

Statins can be life-saving, but the findings suggest their possible side effects should receive greater attention in postmenopausal women.

The study adds to evidence supporting more individualised care for women during midlife.

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