News
UK healthtech company unveils cancer testing strategy for women
Breast, lung and bowel cancers together account for over half of all new cases in women in the UK
The UK healthtech company EDX Medical Group has announced plans to prioritise testing products for cancer affecting women.
Founded by Professor Sir Christopher Evans, the London-based company specialises in cancer treatments and diagnostics.
EDX Medical aims to develop and validate digitally-enabled diagnostic products and services to help predict disease risk, inform clinical decision-making and accelerate the development of new medicines in the areas of cancer, heart disease, neurology and infectious diseases.
According to CancerResearch UK, breast cancer is the most common cancer in UK females, accounting for almost a third (30 per cent) of all female cases. The next most common cancers in UK females are lung cancer (13 per cent) and bowel cancer (10 per cent).
Together breast, lung and bowel cancers account for over half (54 per cent) of all new cases in women in the UK.
“We are driving biomedical and digital innovation in cancer testing at a time when the need for greater access to risk assessment, diagnosis and personalised treatment of cancer has never been greater,” said Dr Mike Hudson, the company’s CEO.
“A key focus of our work is the expansion of advanced tests for cancers affecting women. Early disease detection and risk prediction is the most impactful way of reducing deaths and lowering the future costs of healthcare provision globally.”
Jason Holt, chairman of EDX Medical Group, said: “We are proud to be bringing EDX Medical to the AQSE Growth Market today as an important part of our strategy to develop a substantial digital healthcare business.
“Initially, we are focusing on cancer testing and are building on the expertise and experience of our founder and leadership team particularly in relation to the utilisation of advanced molecular and genomic testing to improve the detection and treatment of cancer.”
EDX Medical operates a molecular biology and diagnostics laboratory in Cambridge from which it performs research and development (R&D) and provides testing and genomic sequencing services.
Key tests performed in this laboratory have been audited by the United Kingdom Accreditation Service (UKAS) and accredited to the International Organization for Standardization.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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