News
Women better protected against early Parkinson’s neurodegeneration, study finds

Women with an early precursor to Parkinson’s disease show much less brain shrinkage than men, despite similar disease severity, new research shows.
The discovery could help scientists explore how hormones might one day be used to treat the neurodegenerative condition.
The findings are based on data from nearly 700 participants across nine international research centres.
The study focused on isolated REM sleep behaviour disorder — a condition in which people physically act out their dreams.
It is considered the most reliable early warning sign of diseases caused by toxic protein build-up in the brain.
More than 70 per cent of those affected later develop Parkinson’s disease, Lewy body dementia or multiple system atrophy, which affects several body systems.
Researchers from Université de Montréal analysed 888 brain scans from centres in Canada, the Czech Republic, the UK, France, Australia, Denmark and Italy.
After quality checks, 687 participants were included: 343 patients with the sleep disorder and 344 healthy controls.
The results revealed clear sex-based differences.
While 37 per cent of the cortical areas — the brain’s outer layer responsible for higher functions — showed thinning in men, only one per cent of regions were affected in women.
This difference remained even though participants were of similar age (around 67) and had comparable clinical profiles.
Marie Filiatrault is first author of the study and a doctoral student at Université de Montréal.
The researcher said: “Men show much more extensive and severe cortical thinning — the outer layer of the brain that controls our higher functions — than women, particularly in areas linked to movement, sensation, vision and spatial orientation.”
To understand the protective effect, researchers compared brain images with gene activity in different regions, measured in healthy brains after death.
They found that the less-affected areas in women showed higher expression of genes related to oestrogen function, particularly ESRRG and ESRRA, which produce oestrogen-related hormone receptors.
The ESRRG gene was especially notable, showing greater activity in brain tissue than elsewhere in the body.
These receptors play key roles in mitochondrial function — the cell’s energy production system — and in the survival of dopamine-producing neurons, the cells that die in Parkinson’s disease.
Shady Rahayel is professor at Université de Montréal’s Faculty of Medicine and lead author of the study.
Rahayel said: “This sleep disorder offers a unique window of opportunity to study the mechanisms of neurodegeneration before major motor or cognitive symptoms appear.
“Our results suggest that certain brain areas in women with isolated REM sleep behaviour disorder are better protected than those in men, likely through the action of oestrogens.”
The team chose to study this precursor condition because it allows observation of brain protection mechanisms before major motor symptoms develop.
Although only 25 to 40 per cent of people with Parkinson’s experience REM sleep behaviour disorder, studying this early stage gives insight into how the brain resists damage when it is still limited.
Previous studies have shown that women with established Parkinson’s disease tend to experience slower progression than men, pointing to similar protective effects.
The findings could shape future research and treatment development.
The authors recommend separating men and women in clinical trials, which could improve statistical accuracy and reduce the number of participants required.
The biological mechanisms identified — particularly those linked to the ESRRG gene — could also become potential therapeutic targets.
Early laboratory research suggests that increasing ESRRG activity may protect dopamine-producing neurons from the toxic effects of alpha-synuclein, a protein that builds up abnormally in the brains of people with Parkinson’s.
“This study brings us closer to precision medicine, where treatments could be tailored not only to the disease but also to individual biological characteristics, including sex,” said Rahayel.
Opinion
What Maternal Mental Health Month reveals about where postpartum support actually breaks down

By Morgan Rose, chief science officer at Ema, and Lauren Scocozza, vice president of product at Willow
May is Maternal Mental Health Month, and every year it surfaces a familiar set of statistics: 1 in 5 new mothers experiences postpartum depression or anxiety, most go unscreened, and the majority who are screened don’t receive adequate follow-up care.
The conversation is important. But the numbers obscure something that anyone who has worked in this space knows to be true: postpartum mental health distress rarely arrives with a label.
It arrives as exhaustion. As “I’m not sure I’m doing this right.”
As a question about supply, pumping, whether it’s okay to feel this disconnected from something you were supposed to love immediately.
Willow integrated Ema, AI built for women’s health, with the goal of closing the maternal care and data gap.
The pattern mentioned above appears consistently in Ema’s conversational data through the Willow app.
A mother reports mastitis symptoms.
Ema walks her through the clinical presentation, confirms she should keep pumping, and then she questions if she is using her pump correctly. In the same thread, within a few exchanges, she says she’s “feeling too sad.” Then: “I don’t know. I think I’m depressed. I am not enjoying my postpartum.”
She did not come to the app to talk about her mental health.
She came about a breast infection. The mental health disclosure came through the already-opened door.
The Weight Underneath the Technical Question
New motherhood involves an enormous amount of problem-solving at a time when cognitive and emotional reserves are depleted. The pump has to work. The baby has to eat. The body has to recover.
Work comes back. Sleep doesn’t. Feeding their babies requires skill, and the learning curve sits atop it all.
What Ema’s conversation data shows is that the emotional load of navigating these challenges is not separate from mental health. It is mental health.
When a mother writes, “I’m postpartum and overwhelmed and tired,” and then, in the same breath, asks about flange sizing, she is telling us what the postpartum experience actually feels like from the inside.
The technical question and the emotional state are one and the same.
Breastfeeding carries particular weight here.
The desire to breastfeed, the guilt when it doesn’t go as planned, and the identity questions that come with feeding choices are not peripheral to the postpartum mental health conversation.
In our conversations, women navigating supply concerns often reveal deeper anxieties: about whether they are good mothers, whether their bodies are “working,” and whether the difficulty they are experiencing means something about them.
These are the signals worth asking about.
What Screening Looks Like in Practice
Ema is trained on the Edinburgh Postnatal Depression Scale and is equipped to offer the EPDS when a conversation warrants it.
The value is being present for the moment when a woman is ready to name what she’s feeling.
That moment rarely comes as a direct request for mental health support. It comes when someone is already in a conversation about something else, and something shifts.
A woman dealing with mastitis says she feels sad. A woman worried about supply says she doesn’t feel like herself. A woman managing the logistics of going back to work with a wearable pump says she’s not sure she can keep up with it all — and the “it all” isn’t about the pump.
Ema is designed to hear that. She doesn’t stay on the clinical or technical track when the conversation moves. She follows the person.
And when the moment is right, she offers the screening as a natural next step.
In one exchange, a woman was offered the EPDS after disclosing depressive feelings. She declined.
Ema acknowledged that and asked if she wanted to talk about something else. That’s the right response. The offer was made without pressure. The door stays open.
Sometimes what matters most is that someone asked at all.
The Continuity Problem
One of the most persistent structural failures in maternal mental health care is fragmentation.
A woman sees her OB at six weeks postpartum for a brief screening. She may get a call from a nurse. She may be given a referral she never follows up on because she doesn’t have the capacity to navigate a new care relationship while managing a newborn.
The clinical touchpoints are too few, too far apart, and too often siloed from one another.
The postpartum period lasts far longer than the six-week checkup implies. Mental health symptoms can emerge weeks or months after delivery, shift in character over time, and interact with physical challenges in ways that don’t fit neatly into any single provider’s lane.
A lactation concern becomes an anxiety spiral. A supply drop triggers a grief response. A difficult return to work surfaces a postpartum depression that wasn’t fully recognized at six weeks.
Ema sits inside these moments because she’s embedded in the platform women are already using. She doesn’t require a separate appointment, a referral, or the cognitive bandwidth to seek out a new resource.
She’s in the Willow app that mom is already using multiple times a day to manage her pump.
When Ema identifies a woman who may need more support than she can provide, she routes to the right resource — whether that’s a SimpliFed lactation consultant for feeding-related concerns or a clinical professional for mental health follow-up.
The conversation leads to the handoff with someone who can do more.
What the Month of May Means for the Rest of the Year
Maternal Mental Health Month is a useful moment of attention. The awareness campaigns, the social media posts, and the statistics shared in newsletters matter.
But the gap in postpartum mental health care is not really an awareness problem.
Most people in the perinatal space and beyond know the statistics. The problem is access, timing, and continuity.
AI doesn’t close that gap on its own.
What it can do is be present in the spaces where women already are, at the times when they need something, and attentive enough to recognise that a conversation about a pump, a clogged duct, or a supply concern is also a conversation about how someone is doing.
The question behind the question is often the more important one.
For Willow, the conversation data Ema generates is a map of where mothers are struggling, what they reach for when they need help, and when they are ready to say more than they came to say.
That information, used well, shapes better resources, better onboarding, and a more connected experience across the full arc of the postpartum year and beyond.
Building the infrastructure to support maternal mental health is a year-round project.
Willow is doing one part of that, and the conversations happening on the Willow platform every day are evidence that women want support that meets them where they are… in their app, in their moment, without having to ask for it twice.
About the authors
Morgan Rose is Chief Science Officer at Ema, an AI platform for women’s health. Ema partners with healthcare organisations and femtech companies to deliver clinically grounded AI support across the perinatal journey.
Lauren Scocozza is the Vice President of Product at Willow Innovations, Inc. For women by women, Willow is building a maternal care platform to address the interconnected challenges of postpartum.
Insight
Online abuse and deepfakes ‘pushing women out of public life’

Deepfakes, AI-assisted rape and unwanted advances are pushing women out of public life, a report has found.
Online violence against women in public life is becoming increasingly technologically sophisticated, with perpetrators able to use AI tools to fabricate intimate images of their targets.
Survey responses suggest these attacks are often deliberate and coordinated, aiming to silence women in public life while undermining their professional credibility and personal reputations.
The report, “Tipping point: Online violence impacts, manifestations and redress in the AI age”, was published by UN Women and produced in partnership with City St George’s, University of London, and TheNerve, a digital forensics lab founded by Nobel laureate Maria Ressa.
It analysed the experiences of 641 women journalists and media workers, activists and human rights defenders from 119 countries. The women were surveyed between 27 August and 13 November 2025.
Researchers found that 27 per cent of women respondents were targeted with unsolicited sexual advances via direct message, receiving unwanted intimate images, “cyberflashing”, sexual innuendos or non-consensual sexting.
A further 12 per cent had their personal images, including those of an intimate nature, shared without their consent, while 6 per cent had been subjected to deepfakes or manipulated images and videos.
The impacts included an alarming rate of mental health diagnoses and self-censorship. Nearly one-quarter, or 24 per cent, of respondents had experienced anxiety and/or depression linked to online violence, while 13 per cent reported being diagnosed with post-traumatic stress disorder, or PTSD.
The findings also pointed to widespread self-censorship, with 41 per cent of respondents saying they self-censored on social media to avoid being abused, and 19 per cent doing so at work.
The study found that while 25 per cent of respondents had reported incidents of online violence to the police and 15 per cent had taken legal action, justice still eluded them. Some 24 per cent of the women who had reported online violence felt victim-blamed by the police, having been asked questions such as “What did you do to provoke the violence?” The same proportion said the police made them feel responsible for shielding themselves from further violence.
Julie Posetti, professor of journalism and chair of the Centre for Journalism and Democracy at City St George’s, is the project’s principal researcher and the report’s lead author.
She said: “AI-assisted ‘virtual rape’ is now at the fingertips of perpetrators. This phenomenon accelerates the harm from online violence inflicted on women in public life.”
“This violence serves to fuel the reversal of women’s hard-won rights in a climate of rising authoritarianism, democratic backsliding and networked misogyny.”
“The rollback of women’s rights is enabled and exacerbated by technologies which, by design, amplify misogynistic hate speech for profit.”
Co-author Lea Hellmueller, associate professor of journalism and associate dean for research and innovation at City St George’s, added: “The chilling effect of online violence is pushing women out of public life.”
“Law enforcement is outsourcing the responsibility for protection to the survivors by telling women to remove themselves from social media, to avoid speaking publicly about controversial issues, to move into less visible roles at work, or to take leave from their respective careers.”
“This shows that avoidance techniques, self-censorship or quitting, are still significantly more likely to be used by women rather than resistance techniques such as reporting online attacks to the police.”
Pauline Renaud, lecturer in journalism at City St George’s and fellow co-author of the study, said: “Going to the police or taking legal action do not necessarily lead to justice for survivors.”
“We need more effective education and training of law enforcement and judicial actors to support action in cases of technology-facilitated violence against women and girls.”
“This needs to be matched by political will to effectively regulate Big Tech companies that use their outsized financial and political power to undermine progress in this area.”
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