News
Preconception BMI linked to fertility and miscarriage risks

Preconception BMI outside the healthy range is linked to longer time to pregnancy and higher miscarriage risk, new research has revealed.
The study followed 3,033 pregnancy or preconception episodes among couples in Rotterdam between August 2017 and July 2021, examining how body mass index (BMI) – weight relative to height – affects fertility.
Women had a median age of 31.6 years and men 33.4. BMI categories were underweight (under 18.5), normal (18.5–24.9), overweight (25–29.9) and obese (30 or greater).
Fecundability – the chance of conceiving in one menstrual cycle – declined with each BMI unit for both sexes.
Women with obesity had a 28 per cent lower chance of conceiving than women of normal weight, while overweight women had a 12 per cent reduction.
Overweight and obese men had an 11 per cent reduction compared with normal-weight men.
The researchers wrote: “A better understanding of the separate and combined associations of BMI in women and men with fertility and miscarriage outcomes is needed to develop novel targeted population strategies to optimise BMI from the preconception period onward.”
Of the cases studied, 17.8 per cent of women were classed as subfertile, meaning conception took more than 12 months. In addition, 11.3 per cent of pregnancies ended in miscarriage, defined as loss before 22 weeks’ gestation.
Underweight women had nearly twice the risk of subfertility compared with normal-weight women.
Overweight women faced a 35 per cent higher risk, while women with obesity had a 67 per cent higher risk.
Miscarriage risks were also higher outside the healthy BMI range: overweight women had a 49 per cent higher risk and women with obesity a 44 per cent higher risk than normal-weight women.
The median time to pregnancy across all participants was 3.7 months. The study also recorded use of assisted reproductive technology, including in vitro fertilisation, among couples struggling to conceive.
The investigators concluded: “Optimising BMI from the preconception period onward in women and men might be an important strategy to improve fertility and pregnancy outcomes.”
Mental health
Lifting weights shows mental health and cognitive benefits in older women, study finds

Weightlifting can improve memory and mental health in older women, whether they lift heavier or lighter weights, a clinical trial has found.
The study suggests structured exercise could offer a non-drug way to help protect the ageing mind.
As people age, physical abilities often decline and the risk of cognitive impairment rises.
Women can also face a higher risk of depression and anxiety later in life because of menopause, hormonal changes and shifting social factors.
Over time, poor mental health can speed up physical and cognitive decline.
Medical professionals often recommend cardiovascular and resistance training to help preserve physical independence.
Beyond building muscle and strength, lifting weights may also help protect the brain.
The research team recruited 120 women with an average age of 68 who were not taking part in any structured exercise programmes.
Before the intervention, independent cardiologists screened the volunteers using diagnostic stress tests to make sure they could take part safely.
The researchers then divided the women into three equal groups based on their baseline physical strength to ensure a balanced comparison.
The first group followed a resistance training programme using heavier weights for eight to 12 repetitions.
The second performed the same exercises using slightly lighter weights for 10 to 15 repetitions. The third acted as a control group and remained sedentary throughout the trial.
For three months, the active groups visited the university fitness facility three mornings a week.
Under the direct supervision of qualified fitness experts, participants completed three sets of eight different full-body exercises. These included weight machines and free weights, with movements such as chest presses, leg extensions, seated rows and bicep curls.
As the women grew stronger over the 12 weeks, supervisors progressively increased the weight they lifted.
This ensured participants stayed within their assigned repetition range while maintaining proper breathing and movement technique. Researchers also told all participants not to start any new exercise outside the laboratory setting.
The scientists carried out a broad set of cognitive and psychological tests before the programme began and again shortly after it ended.
They used the Montreal Cognitive Assessment to measure spatial skills, short-term memory and language processing.
The team also used several standardised surveys to track symptoms of geriatric depression and general anxiety.
Other tests assessed executive function, the mental processes involved in planning, focusing attention and multitasking.
In the Trail Making Test, the women had to connect a scattered sequence of numbers and letters as quickly as possible to assess cognitive flexibility.
In another verbal test, they had to name as many words beginning with the letter F, or as many animals as possible, within 60 seconds.
The researchers also used a computerised Stroop test to assess inhibitory control. In this visual test, the women saw words such as “red” or “black” displayed in conflicting ink colours, such as green.
They had to suppress the automatic urge to read the word and instead press a button matching the ink colour.
After the three-month intervention, both groups of weightlifters showed clear improvements in their test scores.
Their performance on the overall cognitive assessment rose, and their reaction times in executive function tests fell substantially.
The control group showed no such improvements, and in some categories their mental performance worsened slightly.
The structured exercise also reduced the severity of mood disorders among the active participants.
Scores for depressive symptoms fell by roughly 34 per cent in the lower repetition group and 24 per cent in the higher repetition group. Anxiety scores fell by more than 40 per cent in both groups.
The researchers said these improvements met the threshold for a clinically meaningful difference.
In practical terms, that means the psychological benefits were large enough for the women to notice in their daily emotional state.
The trial found no major differences in outcomes between the two repetition strategies, suggesting both intensities worked equally well against cognitive decline.
The study has several caveats that may shape future research into the neurological benefits of structured exercise.
The testing relied heavily on self-reported psychological surveys, which can be affected by subjective bias or temporary changes in mood.
The team also did not closely track differences in the women’s light daily physical activity outside the gym.
The researchers also said the social structure of the fitness programme may have contributed to the emotional benefits.
For 12 weeks, the active participants exercised in a shared, supportive environment, with regular contact with peers and supervisors.
This kind of consistent social interaction can help reduce loneliness and provide psychological relief.
Future trials will need to isolate whether different exercise durations or extra social interaction change these positive neural effects.
Even so, the results suggest resistance training could offer an accessible way to help treat mild cognitive and mood problems.
Regular weightlifting may benefit the mind as well as the muscles in older adults.
Cancer
Poor mental health, poverty and pollution significantly raise women’s heart failure risk – study
Diagnosis
Women gaslit over hysteroscopy pain, Mumsnet posts reveal

Women have described being dismissed and left in serious pain during routine hysteroscopy examinations, with many given little or no pain relief.
Users of parenting forum Mumsnet who underwent hysteroscopy procedures also shared concerns about receiving unclear information before treatment and being given little or no pain relief afterwards.
Some women, who described feeling physically and emotionally vulnerable, compared the experience to sexual assault.
Research led by the University of Reading analysed 4,644 posts from Mumsnet users written between 2018 and 2024.
Susanne Cromme, lead author from the University of Reading, said: “Women in their thousands say they are going into hysteroscopy procedures unprepared, left in more pain than they were led to expect, and feeling that their experience is not being taken seriously, our analysis shows.
“This is not simply an online pile-on. The themes we found in our research are consistent with what clinical studies already tell us about hysteroscopy.
“But by listening to women talk to each other openly, without a researcher in the room, we get a much richer picture of the issues facing patients.”
The study was published following the launch of the Mumsnet campaign to End Medical Misogyny, which is fighting to end the “systemic dismissal, disbelief or de-prioritisation of women’s symptoms in healthcare”, and comes after health secretary Wes Streeting said the health system “too often gaslights women, treating their pain as an inconvenience.”
Justine Roberts, founder of Mumsnet and Gransnet, said: “This research makes clear that too many women are still experiencing severe pain during hysteroscopy, and that problem is compounded by unclear information, inconsistent pain relief and a lack of proper consent.
“These are not one-off failures, they form a repeated pattern and that’s exactly what Mumsnet’s medical misogyny campaign is highlighting: systemic failings in women’s healthcare.
“Nothing encapsulates that more clearly than the expectation that women should endure avoidable pain during gynaecological procedures. If the NHS is serious about tackling medical misogyny, this has to change.”
Around 71,000 hysteroscopy procedures take place every year in England.
According to the analysed Mumsnet posts, women were told procedures would be no worse than a smear test, felt unable to stop once they had started and found that the pain relief available depended entirely on which NHS trust they attended.
The analysis identified five recurring problems among hysteroscopy patients: not enough information before the procedure; women feeling exposed and unprotected; a “postcode lottery” for pain relief, with wide variation between trusts; pain being played down by staff; and an unequal standard of care.
Women also questioned why sedation routinely offered for procedures such as colonoscopies and endoscopies, which examine the bowel and digestive tract, was not available for gynaecological procedures.
The researchers said the findings suggest the problems go beyond individual clinicians, as the posts reflect wider structural issues in women’s healthcare, including potentially underfunded services and unequal standards of care.
The study calls for NHS trusts to introduce standardised consent processes that give women clear information about pain, alternatives and what to expect.
It also recommends consistent pain management protocols across all hospitals, and training for clinicians in trauma-informed care.
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