Mental health
Childhood abuse may leave gene activity changes linked to depression

Childhood abuse may alter gene activity in some women, raising depression risk, UK Biobank analysis suggests.
The pattern was not seen in men, suggesting the biological links between trauma and depression may differ by sex, an area of interest given higher depression rates among women.
Using data from thousands of people in the UK Biobank, the team analysed childhood experiences, mental health and genetic profiles, focusing on a gene network involved in synaptic function, the way brain cells communicate, which is disrupted in depression.
Researchers at McGill University and the Douglas Mental Health University Institute examined this network and found that, among women who experienced childhood abuse, one configuration was linked to a higher risk of depression.
Senior author Patricia Silveira is professor in McGill’s Department of Psychiatry and researcher at the Douglas Mental Health University Institute.
She said: “We know childhood abuse increases the risk of depression at the population level, but at the individual level it’s much harder to predict who will actually develop the disorder.
“Our findings point to a biological mechanism that may help explain who is more at risk, at least in women.”
The work is part of efforts to identify genomic signatures linked to depression risk, which is estimated to affect around 11 per cent of Canadian adults over their lifetime.
Our findings suggest that depression risk is shaped by how genes involved in synaptic function respond to early-life experiences.
That makes synaptic function a promising target for future research,” said co-first author Carla Dalmaz, a visiting professor at the Douglas from the Universidade Federal do Rio Grande do Sul.
“Depression is diagnosed primarily based on reported symptoms, and there are still no widely accepted biological tools in routine clinical practice to identify risk early,” added co-first author Danusa Mar Arcego, a research associate at the Douglas.
“Our findings bring us a step closer to understanding why some people may be more vulnerable, opening the door to earlier support and prevention strategies.”
Mental health
Yoga and omega-3 as effective as therapy for depression in pregnancy, research finds

Yoga and omega-3 supplements may be as effective as talking therapies for pregnancy depression, a major review suggests.
Globally, nearly one in three pregnant women experience depression, but most receive no treatment.
When support is available, women are often directed towards talking therapies such as cognitive behavioural therapy, or CBT, and mindfulness.
CBT is a structured talking therapy that helps people identify and change patterns of thought and behaviour affecting their mental health.
The review examined 115 clinical trials involving more than 12,000 participants across 30 countries.
It found that yoga, massage, omega-3 supplements and bright light therapy were broadly as effective as talking therapies at reducing depression symptoms during pregnancy.
Bright light therapy involves controlled exposure to bright light and is sometimes used to treat mood conditions.
The findings point to the importance of social support and increased connection, as all these approaches offer some element of contact or guided support.
Led by King’s College London, the research brought together trial evidence across every type and format of treatment for antenatal depression under a common framework.
Antenatal depression is depression that occurs during pregnancy.
The study was conducted as part of HappyMums, a European consortium led by the University of Milan that aims to improve mental health support during pregnancy and after birth.
Carmine Pariante, professor of biological psychiatry, said: “This is the most comprehensive analysis of treatments for depression in pregnancy ever conducted, and the findings should prompt a rethink of how we support women during this critical period.
“The evidence is clear that there is no single best approach. What matters is that women have access to a range of options, and that clinicians feel equipped to offer them.”
The researchers said yoga and omega-3 supplements could be legitimate treatment options, rather than stopgaps, for women on waiting lists or those who struggle to access mental health support.
However, the studies differed considerably in design, sample size and how results were measured, so the findings should be interpreted with care.
The team said non-psychological approaches could help women cope with long waits for care without ruling out other treatments alongside them.
Digital and online interventions, including apps and telephone-based support, were also found to be as effective as face-to-face treatment.
Researchers said this could affect how antenatal depression is managed, particularly for women who cannot travel or face long waits for in-person care.
The team found no randomised controlled trials of pharmaceutical treatments for antenatal depression, despite antidepressants being widely prescribed for depression outside pregnancy.
A randomised controlled trial is a study in which participants are randomly assigned to different treatment groups, allowing researchers to compare outcomes more fairly.
Evidence for drug treatment during pregnancy therefore relies on indirect research rather than trials carried out during pregnancy, reflecting long-standing caution around testing medicines in pregnant populations.
NICE guidelines recommend antidepressants for moderate to severe depression in pregnancy, while evidence from outside formal pregnancy trials suggests they can be safe and effective.
However, the researchers said trials are still needed, particularly for women who cannot access or engage with other forms of support.
Riddhi Laijawala, trial manager and PhD student, said: “Depression in pregnancy is common, but it is not inevitable, and it is treatable. What this review shows is that the options available to women are broader than many people realise.
“A yoga class, music therapy, or an online programme may not sound like clinical treatment, but the evidence suggests they can make a real difference, and for many women they may be easier (and quicker) to access than a course of therapy.”
Depression during pregnancy affects an estimated 28.5 per cent of pregnant people worldwide, but only around one in five receives appropriate and timely treatment.
The team said closing this treatment gap should be a priority for health systems because the condition can affect both parent and child.
The HappyMums project is supported by the European Union’s Horizon Europe research and innovation programme.
Mental health
Nearly 60% of young women get health advice from influencers, research finds

Nearly six in ten young women get health and wellness advice from influencers, new research shows.
Women aged 18 to 29 were more likely than young men to use online influencers for health information.
The topics included beauty, alternative medicine, mental health, weight loss and fitness.
The Pew Research study found that 57 per cent of women aged 18 to 29 said they get health and wellness information from online influencers, 10 percentage points higher than young men.
While Americans still mostly rely on healthcare providers, the research suggests social media influencers also play a major role in how young people find health advice.
Among women who get health and wellness information from influencers, 51 per cent said they often hear about beauty and appearance, compared with 18 per cent of men.
Young women were also around twice as likely as young men to say they see content about alternative medicine, meaning treatments or health practices used outside mainstream medical care.
A third or more of both young men and young women said they often hear about mental health and weight loss from influencers.
Around half or more of both groups said they often see fitness content.
When asked why they seek health and wellness information from influencers, around half of young women said they wanted to make a change to their health or lifestyle.
That compared with 37 per cent of young men.
The research also found that 23 per cent of young women said hearing from people who share their background or beliefs was one reason they used influencers, compared with 14 per cent of young men.
A further 19 per cent of young women said they learnt about things they did not want to ask their doctor, compared with 10 per cent of young men.
Mental health
Cosmetic procedures may become addictive for some women, researchers say

Cosmetic procedures may become addiction-like for some women, with low body esteem and problematic social media use linked to higher risk, new research suggests.
A study of 1,614 women aged 25 to 71 found that one in five who had undergone treatments met the threshold for moderate to severe risk of addictive cosmetic procedure use.
Low body esteem and problematic social media use emerged as the strongest risk factors.
Researchers from the Hebrew University of Jerusalem and the Israel Center for Addiction and Mental Health examined what they described as addictive cosmetic procedure use, or ACPU, among Jewish Israeli women.
ACPU refers to repeated cosmetic treatment behaviour that may resemble addiction, including feeling unable to stop, continuing despite negative effects or craving further procedures.
The study was led by Vera Skvirsky alongside Uri Lifshin, Dvora Shmulewitz and Mario Mikulincer, from the department of psychology at the Hebrew University of Jerusalem and the Israel Center for Addiction and Mental Health.
The researchers surveyed women from the general population rather than focusing only on patients at cosmetic clinics.
Among women who had undergone cosmetic procedures, 20 per cent met the threshold for moderate to severe lifetime risk, while more than 15 per cent reported symptoms within the previous year.
Across the full sample, nearly nine per cent of women showed moderate to severe signs of problematic cosmetic procedure use.
The researchers adapted questions based on mental health criteria used to assess substance-related disorders.
Participants were asked whether they had tried unsuccessfully to stop having cosmetic procedures, felt compelled to continue despite negative consequences or experienced cravings linked to treatment.
Previous research has linked cosmetic procedures with body-image concerns and body dysmorphic disorder.
Body dysmorphic disorder is a mental health condition in which a person becomes highly distressed by perceived flaws in their appearance, often flaws that others may not notice.
The new study examined whether repeated cosmetic procedures may, in some cases, resemble a behavioural addiction.
Women with lower body esteem were more likely to report addiction-like patterns, particularly when this was combined with high levels of problematic social media use.
Participants who reported problematic or excessive social media behaviour appeared especially vulnerable when they also felt dissatisfied with their appearance.
The researchers also found smaller links between addictive cosmetic procedure use and lower feminist attitudes, lower attachment security and more negative attitudes towards ageing.
However, those links were less consistent when several factors were analysed together.
The findings come amid a sharp global rise in cosmetic procedures, with international estimates cited by the researchers suggesting interventions increased by around 40 per cent between 2019 and 2023.
The researchers stressed that the study does not suggest cosmetic procedures are inherently harmful.
Instead, they said repeated engagement may, for some people, take on characteristics similar to behavioural addictions already recognised in mental health research.
The researchers said: “Cosmetic procedures have become deeply normalised in many societies, and for many people they may be a positive experience.
“But our findings suggest that for a meaningful minority, the behaviour may begin to resemble other compulsive patterns we see in addiction research, especially when low body esteem and problematic social media use are involved.”
The study was cross-sectional, meaning it captured a single point in time and cannot prove cause and effect.
Researchers said it remains unclear whether problematic social media use contributes to addiction-like cosmetic procedure behaviour, whether treatments influence body image and online engagement, or whether other psychological factors drive both.
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