Fertility
What Depo-Provera litigation means for the future of women’s health

By Aron Solomon, Pulitzer Prize-nominated writer and chief strategy officer for Amplify
For decades, Depo-Provera was marketed as a convenient, long-lasting birth control option for women who want to take control of their reproductive health without the hassle of daily pills.
It was sold as a solution—an easy shot every three months that promised reliability and freedom.
But what was often left out of the conversation was the growing body of evidence linking the drug to serious, long-term side effects, including bone density loss, increased risk of certain cancers, and severe mental health impacts.
And now, lawsuits against the makers of Depo-Provera are bringing those risks into the national spotlight.
But this fight isn’t just about compensation. It’s about something much bigger: transparency, accountability, and the demand for better healthcare for women.
The lawsuits against Depo-Provera’s manufacturer aren’t happening in a vacuum.
They are part of a broader, long-standing pattern of medical products being introduced, marketed, and prescribed to women without full disclosure of their risks.
Time and time again, women’s health concerns have been dismissed, downplayed, or outright ignored until legal action forces the issue.
We saw it with the Dalkon Shield IUD in the 1970s, which led to infections, infertility, and deaths before it was pulled from the market and resulted in a massive lawsuit.
We saw it with the Yaz and Yasmin birth control pills, which were linked to life-threatening blood clots and only got black-box warnings after lawsuits mounted. And we are seeing it now with Depo-Provera.
At the heart of these lawsuits is a simple but powerful demand: women deserve to know what they’re putting into their bodies.
They deserve full transparency about risks, not sugarcoated reassurances or buried data.
Depo-Provera has been linked to decreased bone mineral density, a serious issue that can lead to osteoporosis later in life.
Studies have shown that the loss is often not fully reversible, yet many women were never warned about this before they started using the drug.
There is also an increased risk of cancer and mood disorders like depression and anxiety—again, side effects that weren’t always fully disclosed or studied in depth before Depo-Provera was widely distributed.
The legal action against the manufacturers of Depo-Provera represents more than just a quest for justice for those who have suffered—it’s a means of demanding systemic change.
These lawsuits pressure pharmaceutical companies to do better, not just in how they test and approve drugs but in how they communicate risks to patients.
They send a clear message that women are no longer willing to accept subpar treatment when it comes to their health. And they put the medical establishment on notice: accountability is no longer optional.
A crucial part of this movement is the push for more inclusive and thorough clinical research.
Historically, medical research has been male-centered, with women often being treated as an afterthought.
This has led to an incomplete understanding of how drugs affect women’s bodies differently.
When women’s unique health needs aren’t properly studied, they aren’t properly addressed—and that has real consequences.
The Depo-Provera lawsuits highlight the need for drug trials that take women’s long-term health seriously, rather than treating side effects as acceptable trade-offs.
Beyond the pharmaceutical industry, these lawsuits are also challenging the role of healthcare providers in informed consent.
Many women report that they were never told about the full extent of Depo-Provera’s risks before receiving the shot.
Some were assured that side effects were minimal or temporary, only to later discover that their bone density had been permanently compromised.
Others struggled with severe depression or anxiety, unaware that their birth control method could be a contributing factor.
Informed consent isn’t just a legal formality—it’s a fundamental right. Women have the right to make decisions about their bodies based on complete, unbiased information, and these lawsuits are reinforcing that right.
The implications of this legal battle extend far beyond Depo-Provera. They are part of a larger cultural shift in how we approach women’s healthcare.
Women are demanding better—not just in birth control options but in all aspects of reproductive and general health.
They are calling for safer medications, clearer communication, and a medical system that prioritises their well-being rather than treating them as a market for profitable drugs.
This movement is already starting to see results.
The increased scrutiny around Depo-Provera and similar cases is prompting more discussions about alternative birth control methods and the need for more research into safer, hormone-free options.
It’s pushing regulators to be more aggressive in requiring clear warnings and more thorough testing. And it’s empowering women to ask more questions, demand better answers, and take an active role in their healthcare decisions.
The lawsuits against Depo-Provera are not just about financial settlements. They are about changing the way women’s health is treated in this country.
They are about shifting the balance of power so that women are no longer passive recipients of whatever the pharmaceutical industry decides to sell them.
They are about ensuring that future generations don’t have to fight the same battles over and over again just to get basic transparency and respect in medical care.
Legal action has long been one of the most powerful tools for change, and in the case of Depo-Provera, it’s proving to be an essential force in the fight for better women’s healthcare.
The message is clear: women will no longer accept being kept in the dark about their own health.
They are standing up, speaking out, and demanding better. And the medical world—pharmaceutical companies, doctors, and regulators alike—needs to start listening.
Fertility
AI could transform ovarian care through personalisation, study finds

AI could transform ovarian care by personalising cancer and fertility treatment, but more clinical validation is needed before routine use.
A systematic review and meta-analysis found AI models showed high diagnostic accuracy for ovarian cancer when combining data such as ultrasound scans and blood test results.
Across 81 studies, AI models correctly identified ovarian cancer in around nine out of 10 cases, with pooled rates of 89 to 94 per cent.
They were also highly accurate at ruling out ovarian cancer when it was not present, with specificity of 85 to 91 per cent.
The analysis also found that explainable AI tools could predict complete surgical cytoreduction in advanced ovarian cancer.
Complete surgical cytoreduction means removing all visible cancer during surgery, which can be an important goal in treatment planning.
The tools achieved a pooled AUC of 0.87. AUC is a measure of how well a model distinguishes between different outcomes, with higher scores showing stronger performance.
In reproductive medicine, AI algorithms helped physicians optimise ovarian stimulation protocols and predict follicular growth during IVF.
Ovarian stimulation is the use of hormones to encourage the ovaries to produce eggs, while follicles are the small sacs in the ovaries where eggs develop.
The review found AI could reliably model ovarian response in IVF with a pooled AUC of 0.81.
However, researchers said challenges remain in translating promising research findings into routine clinical practice.
They identified substantial variation across studies, driven by retrospective study designs, variable AI systems and a lack of standardised validation.
Only 22 per cent of analysed studies reported prospective, multicentre external validation, where models are tested forward in time across multiple healthcare settings.
The authors called for rigorous validation to help close the gap between research and routine clinical practice, alongside standardised methodological and reporting frameworks, smooth integration with clinical workflow and robust governance to support responsible and ethical AI use.
They concluded: “Artificial intelligence is a transformative force in the management of ovarian conditions.
“In gynaecologic oncology, AI enhances every phase of care, from early detection and accurate diagnosis to prognostic stratification and surgical planning.”
In reproductive medicine, AI personalises ovarian stimulation and refines the diagnosis of heterogenous endocrine disorders such as PCOS.
PCOS, or polycystic ovary syndrome, is a hormonal condition that can affect periods, skin, weight and fertility.
Fertility
Housing, work and fertility stop Britons having the families they want – research
Fertility
Femtech World reveals fertility innovation award shortlist

Femtech World is thrilled to reveal the shortlist for the Fertility Innovation Award.
The award, sponsored by FinDBest IVF, celebrates a pioneering product, service or initiative that is transforming fertility care and support.
FinDBest IVF is a global B2B digital platform created to simplify and accelerate how IVF and ART manufacturers connect with trusted, pre-vetted distributors around the world.
This year’s nominees represent a remarkable breadth of approaches to fertility care: from clinic-floor breakthroughs to at-home hormone intelligence to truly borderless access.
Three companies made the cut, with each tackling a real, persistent barrier in reproductive health.
Congratulations to the shortlist and many thanks to everyone who entered.
Fertility Innovation Award Shortlist

HRC Fertility’s Needle-Free IVF is a pioneering advancement designed to transform one of the most challenging aspects of fertility treatment: daily hormone injections.
Developed by board-certified reproductive endocrinologist Dr Rachel Mandelbaum, this innovative approach reimagines how stimulation medications are delivered during IVF and egg freezing, dramatically improving the patient experience while maintaining the same trusted clinical outcomes.
Inspired by feedback from patients who struggled with the injection process, Dr Mandelbaum adapted an innovative drug-delivery system commonly used in other areas of medicine and applied it to reproductive care

Mira is a hormonal health technology company that provides lab-grade hormone testing and AI-driven insights to help women and couples understand their fertility.
The platform has already supported more than 200,000 couples on their fertility journeys worldwide, helping over 60,000+ users achieve pregnancy.
For some users, pregnancy rates have reached up to 89 per cent within six months, demonstrating how accurate hormone data can significantly improve fertility outcomes.

Founded in 2021 by Marija Skujina, a Certified Fertility Nurse Specialist accredited by the European Society of Human Reproduction and Embryology, with nearly 15 years of clinical experience at one of the world’s top IVF clinics, and having navigated her own fertility journey as a patient, Marija built the clinic she had always wished existed.
Plan Your Baby began with a bold, but simple mission – make best quality fertility and pregnancy available anywhere.
Plan Your Baby has created a new generation fertility and pregnancy clinic with patients accessing expert consultations remotely, while blood tests and ultrasound scans are available at over 450 locations across the UK, eliminating the exhausting travel burden that often forces people to take days off work, relocate appointments, or abandon treatment altogether
What happens now
The shortlist will be judged by a representative from category sponsor FindBestIVF, with the winner announced at a virtual event on June 19.
Winners will receive a trophy and be interviewed by a Femtech World journalist.
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