News
AIVF acquires IVF software ART Compass to advance fertility care
AIVF, the Israeli developer of the first AI-based IVF software platform, has announced the acquisition of ART Compass, an application for the management of the IVF laboratory.
The company says the acquisition of ART Compass will expand its offering and create traction in the US.
AIVF’s flagship product, EMA, is an AI software platform that delivers automated and actionable insights to optimise the fertility journey.
“This first acquisition adds novel capabilities for the expansion and integration of our FertilityOS in clinics,” said Daniella Gilboa, AIVF CEO and co-founder.
“Strategic industry partnerships like this support our mission to accelerate the digital transformation of fertility care.”
Dr Carol Lynn Curchoe, founder of ART Compass, said: “The ART Compass application is a first step toward digitalisation of the unstructured, complex, and often ‘on paper’ data in the IVF lab.
“It is a perfect fit to be part of the advanced AI-powered platform that AIVF is bringing to global fertility clinics.”
Dr Curchoe will take the position of director of medical affairs at AIVF.
Integration of ART Compass into the EMA platform for fertility clinics is planned for the first quarter of 2023.
The news comes four months after the medtech company announced it raised US$25 million to expand its work force and advance digital fertility care.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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