Menopause
Menopause hair loss system shows trial promise

Menopause hair loss trial data showed what the company called clinically meaningful regrowth from a scalp system in a phase II study of menopausal women.
The four-month independent trial evaluated Prevention and Treatment Serums in 43 menopausal-aged women with androgenetic alopecia.
Androgenetic alopecia is a common form of hair thinning.
The trial was announced by dermatologist-founded brand KilgourMD.
Dr James Kilgour, board-certified dermatologist, founder and chief executive of KilgourMD, said: “Menopausal women have been largely excluded from rigorous hair loss research, despite experiencing some of the most challenging and persistent forms of thinning.
“This study validates not only the performance of the KilgourMD System, but also the importance of designing and testing solutions specifically for this population.
“These results represent a meaningful step forward in how menopausal hair loss is treated.”
Unlike many studies in this category, eligibility required a clinically significant level of hair loss, and outcomes were objective and dermatologist-evaluated rather than consumer perception surveys.
By day 120, the company said 53 per cent of participants achieved at least a half-grade improvement on the modified Female Ludwig scale, a clinical scale used to rate the severity of female hair loss.
This threshold is considered by dermatologists to represent a meaningful visual change. A further 26 per cent showed a full one-grade improvement.
KilgourMD said this level of improvement is comparable to, and in some cases exceeds, results typically reported after six to 12 months of conventional pharmaceutical therapies such as minoxidil or finasteride.
Across the full study population, participants experienced an average 11.1 per cent improvement in Ludwig score within four months, the company said.
The trial also reported a 60 per cent reduction in hair shedding by month four, measured through standardised combing and washing assessments.
Reductions were seen as early as day 45, when more than 95 per cent of participants showed a decrease from baseline in terminal hair shedding count, measured by standardised hair washing studies in the lab.
Regrowth outcomes were graded by two independent board-certified dermatologists, with high-resolution imaging used to confirm visible improvements in hair density and scalp coverage over time.
More than 80 per cent of participants reported noticeable improvements in hair density, health and overall appearance by the end of the study.
The full results are currently undergoing peer review and are expected to be published later this year.
Menopause
Cultural stigma is a barrier to menopause help, black women say

Cultural stigma and a lack of education are making it harder to get menopause help, ethnic minority women in Jersey have said.
The women came together to share their stories at an event in St Helier hosted by Eve Studios and Liberty Underwear.
Participants were encouraged to speak openly about the symptoms they had experienced.
Angela Mowanga, from Jersey, told ITV Channel: “I became dismissive about signs and symptoms. From our parents and our grandparents, they just carried on.
“I hardly heard the word menopause spoken about in my household. We never had things like hot flushes, itchy skin and tiredness.
“So for us to start talking about menopause, there is a taboo around it. A taboo that comes from ignorance but also not being willing to educate ourselves.
“We as women of colour, societies of colour, we have a lot of taboo subjects, which now have to be highlighted with the generation today.
“However, with the modern day, society is changing. And we hope programmes like this can actually be well received.”
Daisy Ayebale, from Jersey, added: “I think it’s important we are listened to. We need the right information from the experts, but we have also been overlooked when it comes to the healthcare system.
“We need to know this information before it’s too late, before you’re gambling with your health. We are glad to be changing the narrative, we are glad to be changing things right now. We are very hopeful.”
Research shows that black women are more likely to experience menopausal symptoms earlier, more intensely and for longer.
Insight
Women urged to be wary of menopause misinformation on social media

Women are being urged to seek evidence-based advice and avoid menopause misinformation shared on social media.
A seminar co-hosted by the World Health Organization (WHO) mainly examined what is known about the cognitive effects of menopause and current research in the field worldwide.
Dr Nicole Jaff, a South African academic and certified menopause practitioner, said research into menopause and its effects was now at a peak.
She said: “There’s a lot of information out there.
“But I would say please look for the evidence-based information, not for the influencers and the misinformation, but those who are giving guidelines, who are giving information.”
Jaff highlighted research into cognitive changes during menopause and how some women experience brain fog, a term for difficulties with memory, concentration and clear thinking.
She said: “I’m very excited about the non-hormonal treatments that are now available, especially for women who could never take hormone therapy because of breast cancers and various cancers, who can now take it.
“I’m extremely excited about people who are standing up for evidence-based medicine, for science, who are actually fighting back against a lot of the social media and influencers who are not giving evidence-based information and making life very difficult for women because they think they should be forever young or buying this or buying that.”
Jaff advised women and healthcare workers to read new guidelines recently issued by the International Menopause Society. They are available free to download from its website.
The seminar also heard from Professor Aimee Spector, professor of clinical psychology of ageing at University College London.
She raised similar concerns about misinformation, particularly claims linking hormone replacement therapy, known as HRT, to dementia. Some claims suggest HRT reduces dementia risk, while others suggest it increases the risk.
Spector said: “I think there’s also lots of misinformation.
“And I think that there’s huge variations in how even professionals and doctors interpret this information.”
She was part of an international research team commissioned by the WHO last year to assess published studies on the issue.
The institutions involved also included the Global Brain Health Institute at Trinity College Dublin.
Spector said: “The first thing to say is that the quality of evidence was very low.
“Nine out of the 10 studies we looked at were observational, which means that you’re observing patterns over time. But you don’t necessarily know whether that’s due to the hormone therapy or not.
“Our overall recommendation was that there’s insufficient evidence for menopause hormone therapy in terms of either increasing or reducing the risk of dementia. In other words, we don’t know either way.”
Spector said women should therefore decide whether to use HRT to treat menopause symptoms rather than based on concerns about dementia.
She said: “It’s recommended for menopause symptoms, but it’s not recommended to reduce dementia. And I think a lot of people are saying that.”
The Menopause on the Brain webinar was part of an ongoing series hosted by the WHO and other global health agencies.
News
Premature menopause is a high blood pressure risk, study finds

Premature menopause is linked to a higher risk of developing high blood pressure, according to a study of more than 107,000 women.
The risk was highest among women who reached menopause between the ages of 25 and 35.
Researchers said the findings support earlier cardiovascular screening for women who reach menopause before the age of 40.
Dr Stephanie Faubion, medical director for The Menopause Society, said: “The results of this study highlight the potential adverse long-term health outcomes associated with premature menopause, and in particular, the need to regularly screen for cardiovascular risk factors such as hypertension.
“Use of hormone therapy is also routinely recommended in women with premature menopause at least until the natural age of menopause unless contraindications exist.”
Hormonal changes during menopause are known to affect women’s wider health, while earlier menopause has previously been linked to coronary heart disease and stroke.
Coronary heart disease develops when the blood vessels supplying the heart become narrowed or blocked.
However, previous evidence directly linking the timing of menopause to high blood pressure has been mixed.
High blood pressure, also known as hypertension, puts extra strain on the heart and blood vessels and can increase the risk of heart disease and stroke.
Researchers said it can be difficult to separate the direct effects of hormonal changes from factors that often accompany menopause, including weight gain, metabolic changes and other cardiovascular risks.
Metabolic changes affect how the body processes and uses energy, including sugar and fat.
The study analysed data from 107,836 postmenopausal women who joined the UK Biobank between 2006 and 2010. They were followed for a median of almost 15 years.
Researchers divided the women into three groups based on their age at menopause: after 45, between 40 and 45, or before 40.
They also examined whether menopause occurred naturally or followed surgery.
During the follow-up period, 18,508 women, or 17.2 per cent, were diagnosed with high blood pressure.
The proportion increased as the age at menopause fell. Hypertension developed in 16.6 per cent of women who experienced menopause after 45, compared with 18.8 per cent of those who reached menopause between 40 and 45.
Among women who experienced menopause before 40, 22.6 per cent developed the condition.
After taking account of more than 50 factors, including weight, lifestyle habits, family history and laboratory results, premature menopause remained linked to a 12.3 per cent higher risk of hypertension than menopause after age 45.
Further analysis suggested the risk peaked among women who reached menopause between the ages of 25 and 35.
The researchers said this may mean that the cardiovascular risk associated with premature menopause is concentrated among a younger group than the conventional under-40 definition suggests.
Surgical menopause was initially linked to higher rates of hypertension, but the association was no longer significant after other risk factors were taken into account.
The authors said clinicians should consider age at menopause as a distinct cardiovascular risk factor, particularly for women who experience it before 40.
They also called for earlier detection and management of hypertension, alongside individual discussions about hormone therapy.
Hormone therapy replaces hormones that decline during menopause and may be recommended for some women, depending on their individual health and medical history.
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