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Precision oncology is here — So why are so many breast cancer treatments still a gamble?

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By OncoGenomX, Allschwil, Switzerland

When it comes to breast cancer treatment, one truth remains painfully clear: despite decades of progress we still cannot answer the question which treatment(s) a tumour will respond to.

At OncoGenomX, we think it’s time to change that.

We now have tools that allow us to look inside a tumour, understand how it behaves, and predict what treatments will work best—not just for a cancer subtype, but for an individual tumour, with its unique biology.

It’s called Precision Oncology, and it’s one of the most promising frontiers in cancer care. But right now, its full potential is still out of reach for too many patients.

So why the gap?

The Promise: Personalised Treatment That Works the First Time

The dream of precision medicine is simple: treat the person, not just the disease.

In breast cancer, doctors already use some personalised tools. For example, hormone receptor tests help decide whether a patient should receive endocrine therapy.

Genetic tests like Oncotype DXTM or MammaprintTM can help determine whether chemotherapy is needed. These are great first steps.

But here’s the problem: these tools don’t go far enough. They often tell us what could work, but not what will work. Many patients are still treated based on probabilities and population averages, not precise predictions tailored to their specific tumour.

The result? Too many women receive therapies that don’t work—or stop working quickly. Some get treatments that are too aggressive. Others don’t get enough.

The Reality: Cancer Is Chaotic

Part of the reason breast cancer is so difficult to treat is that no two tumours are alike. Even within a single tumour, cells can behave very differently.

Scientists call this “coordinated chaos.” It means that a treatment might hit some parts of a tumour—but miss others entirely. It also means that two women with the “same” diagnosis may need completely different treatments.

In one major study, only about 1 in 5 patients with advanced cancer actually received all the treatments they were genetically eligible for. Even more worrying: in half of the cases, at least one drug in the treatment plan was likely ineffective.

This isn’t just a medical issue—it’s an economic one. Unmatched or suboptimal therapies drive up costs, delay results, and cause unnecessary side effects.

Precision isn’t just better for patients—it’s better for health systems too.

The Breakthrough: Predicting Treatment Response

At OncoGenomX, we believe the missing link is prediction.

We need tools that can do more than classify tumours or identify potential drug targets. We need models that predict how a specific tumour will respond to tailor-made treatment combination.

That’s why we created PredictionStar™, a clinical decision-support tool designed to help oncologists choose optimal treatment combinations, earlier.

It works by analysing real patient data, tumour biology, and how different therapies interact—so doctors can plan treatment combinations based on what’s most likely to work in concert.

In hypothesis generation studies, we’ve seen a 15–22 per cent improvement in treatment success rates—especially beyond first-line therapy. And when treatments work better, patients do better: survival improves, side effects decrease, and costs drop.

The Future: Smarter, More Human-Centered Oncology

We’re not claiming to cure cancer. But we do believe that better decisions lead to better outcomes.

Our goal is to help oncologists move away from treatment decisions based on probabilities and population averages towards truly rational and individualised treatment planning. That means:

Understanding which therapies are likely to work before trying them

Combining treatments in ways that maximise long-term benefit

Matching each patient to the right combination—any treatment line

This is especially important for women’s health.

Breast cancer is the most common cancer among women worldwide. Yet many women still receive treatments that don’t reflect the full complexity of their disease—or the sophistication of today’s science.

Why It Matters for FemTech

At its core, precision oncology is a FemTech issue. It’s about using technology, data, and science to improve women’s lives.

Breast cancer doesn’t affect all women equally. Outcomes vary by age, race, income, and geography.

That’s why we must ensure that the tools of precision oncology are accessible, equitable, and informed by real-world data from all patients—not just clinical trial populations.

By combining human data, artificial intelligence, and biology, we can move toward a future where every woman receives the best possible care, from the very first treatment.

A Question Worth Asking

If there were a tool with the potential to help doctors select the right treatment combination for a patient’s tumour—based on predictive information—wouldn’t we want them to use it?

At OncoGenomX, we think the answer is clear.

The future of breast cancer care is personal. Let’s make it predictable, too.

Find out more about OncoGenomX at oncogenomx.ch

 

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EU healthcare’s gender pay gap hits 19%, WHO report finds

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Women in Europe’s health and care sector face a 19 per cent hourly gender pay gap, according to a new World Health Organization (WHO) report.

Women account for 77 per cent of the sector’s workforce, compared with 45 per cent across all other sectors combined, but make up only 55 per cent of its top earners.

The hourly gender pay gap widens at higher wage levels, from 2 per cent among the lowest earners to more than 22 per cent at the top.

The WHO report found that health and care accounts for almost 17 per cent of all women’s employment in its European Region, compared with 5 per cent of men’s employment.

The sector is the fourth-largest employer overall and the single largest employer of women in the region.

Natasha Azzopardi Muscat, director of the Division for Health Systems at WHO Europe, said: “Women make up the majority of the people who keep Europe’s health systems running, yet they’re paid less than their male counterparts, a gap that compounds over a lifelong career.”

The findings follow a pattern seen across the wider labour market, with structural inequality increasing at higher wage and seniority levels.

Globally, women working in health earn an average of 24 per cent less than men, according to the report, a wider gap than in many other industries.

Some of the difference in pay could be explained by work-related factors, including age, education, public or private sector employment and whether people worked full-time or part-time.

After adjusting for those four factors, the hourly pay gap fell from 19 per cent to 6 per cent, while the monthly gap declined from 28 per cent to 10 per cent.

The remaining difference could not be explained by factors measured in the data.

“Most of this gap isn’t down to women working fewer hours, being younger or working in different parts of the sector,” Azzopardi Muscat said.

“It comes down to how the sector values women’s work. Age, education, working hours and public versus private sector employment only helps explain some of it.”

WHO said the findings point to factors including the undervaluation of care work, occupational segregation and potential discrimination in pay-setting practices.

Occupational categories with a higher proportion of women paid less across managerial, professional and technical roles.

Management jobs in health and care employ more women than management roles in other sectors and pay an average of €22 per hour, compared with €24.70 in comparable roles elsewhere.

WHO described the gender pay gap as one of the most persistent forms of labour market inequality. Given the number of women working in health and care, it said the gap could have important economic and social consequences.

The report said the inequality may lead to lower lifetime earnings and pension entitlements, increase women’s risk of poverty, reduce returns to education and undermine sustainable economic growth.

“It means lower pensions, less financial security in older age, and a higher risk of poverty for women who’ve spent their working lives caring for others,” said Azzopardi Muscat.

“This isn’t a coincidence, and it isn’t about qualifications. Women are being paid less for the same work and passed over for the roles that pay more.”

WHO said closing gender pay gaps was both an equity imperative and an investment in a stronger and more sustainable health workforce.

It suggested measures including greater salary transparency, increased female representation in decision-making roles and action to address gender norms and stereotypes.

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Women with birth trauma face 2.5x higher healthcare costs – study

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Women with childbirth-related PTSD had healthcare costs 2.5 times higher than women without PTSD from six to 12 months after birth, a report found.

The analysis estimated that early prevention of traumatic births and childbirth-related post-traumatic stress disorder (PTSD) could save the NHS around £26m each year.

Women with PTSD were also less likely to have returned to work by 12 months after giving birth, suggesting potential longer-term employment and economic effects.

The report from City St George’s, University of London was launched at an All-Party Parliamentary Group (APPG) on Birth Trauma event on 10 September 2026.

Researchers calculated the potential NHS savings using the number of births reported in NHS hospitals in 2024-25 and the UK prevalence of childbirth-related PTSD.

Around one in 20 women in the UK develop PTSD following childbirth, while recent research has shown that the condition remains underdiagnosed.

The findings draw on research that tracked more than 2,000 women in England and Scotland from pregnancy to two years after birth. Researchers assessed mental health, use of health services and employment outcomes.

The research included assessments of childbirth-related PTSD and PTSD arising from other traumatic experiences. It also included a separate Birth Trauma Association survey examining women’s experiences of birth trauma.

Between six and 12 months after birth, healthcare and support service costs for women with childbirth-related PTSD were 2.5 times those of women without PTSD.

Women with low or moderate symptoms, including those reporting one or two PTSD symptoms, also had higher healthcare service costs than women without PTSD.

Just over half, 53 per cent, of women with PTSD had returned to work by 12 months after giving birth, compared with 68 per cent of women without symptoms.

Women with PTSD were more likely to be referred for mental health support, but more than half received no referral.

Those whose PTSD followed a traumatic birth also had slightly higher healthcare costs than women whose PTSD resulted from other traumatic experiences.

The researchers called for routine PTSD assessment and treatment during pregnancy and after childbirth, alongside greater access to specialist perinatal mental health services.

They also recommended training healthcare staff in perinatal trauma, trauma-informed care and identifying women at risk of PTSD.

The report said further research was needed to establish whether screening, treatments and trauma-informed care pathways are effective and evidence based.

The work follows the APPG’s 2024 Birth Trauma Inquiry, which highlighted the effects of birth trauma on women and families and called for evidence on its wider public health and societal costs.

The report focused primarily on healthcare use and did not attempt to calculate all costs associated with birth trauma and postnatal PTSD, including wider employment, family and societal effects.

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UK reviews surrogacy firm over rejected insurance claims

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The UK government is reviewing a surrogacy firm after complaints that medical insurance claims involving surrogates in Mexico were rejected.

The Department of Health and Social Care (DHSC) is considering whether UK-based provider My Surrogacy Journey should remain listed on gov.uk as one of four domestic surrogacy agencies available to intended parents.

The review follows allegations concerning its Mexican sister company, where surrogates are based.

Health minister Diana Johnson said: “The department is looking into the allegations about My Surrogacy Journey.

“As part of that assessment, the department will consider whether it is appropriate for that company to remain on the gov.uk list of agencies.”

Emails sent by My Surrogacy Journey chief executive Michael Johnson-Ellis and seen by the Guardian suggest multiple surrogate women in Mexico had their insurance claims rejected.

The emails also suggest 300 couples using the company were moved to a new insurance provider because of the increased risk of claims being rejected.

Commercial surrogacy is banned in the UK, where only altruistic arrangements are permitted.

My Surrogacy Journey operates a not-for-profit UK branch alongside for-profit sister companies in Mexico and the US. All three companies have the same owners and chief executives.

The reported insurance issues relate to surrogacy arrangements in Mexico.

One couple told the Guardian they paid tens of thousands of pounds to cover medical costs after their surrogate had a hysterectomy during childbirth and an insurance claim was refused.

The Guardian said it understood that at least five sets of parents said they had to cover medical costs after insurance claims were rejected.

In an email to the couple whose surrogate underwent a hysterectomy, Johnson-Ellis wrote: “We have already told you that the insurance companies have been declining some of the claims and we are actively working with the broker to get this issue resolved but you should also consider that they may not be paid out and there is nothing we are able to do to change this …

“We appreciate this is not an insignificant sum but this genuinely is out of our control.”

Johnson-Ellis also said the company had switched insurance providers, writing: “We’re also managing this for 300 other journeys, which is a complex position to be in.”

Lawyers acting for My Surrogacy Journey said the company did not comment on individual cases, but that existing insurance policies were in place and claims continued to be accepted and processed.

They said the company understood that a small number of claims had been rejected and was supporting people seeking to resolve those claims with an insurer.

Under the surrogacy arrangements, intended parents are understood to be contractually required to cover medical costs not paid by an insurer.

The couple said they had been recommended the company’s Mexico option. Its website advertises that intended parents using the route can have a baby in “under 18 months”.

They said they were told the UK route could take up to five years and that the US option was much more expensive.

Lawyers for My Surrogacy Journey said prospective parents are given information about typical timelines, costs, legal frameworks and practical considerations, and that the 18-month timeframe is indicative only.

The couple said their surrogate developed placenta accreta, a serious condition in which the placenta attaches to the wall of the uterus.

Emails from Johnson-Ellis acknowledged that the insurance provider investigated the birth after the surrogate experienced health complications.

The parents are considering legal action, while the Guardian said it understood at least four other couples were reviewing their options.

Phil Brickell, MP for Bolton West, raised concerns in parliament about a separate couple who had used My Surrogacy Journey.

He said: “Two of my constituents recently travelled to Mexico, where their children were born by surrogacy.

“Those births were facilitated by a company called My Surrogacy Journey, which is listed on gov.uk.

“While in Mexico, they had repeated traumatic experiences with the company relating to issues including insurance for their children, accusations of bullying towards staff and repeated efforts to silence any constructive criticism.

“I understand that other members of this house have received similar complaints.”

Brickell called for My Surrogacy Journey to be removed from gov.uk pending a review by the Human Fertilisation and Embryology Authority.

Lawyers acting for My Surrogacy Journey said the company was communicating with DHSC and was confident any issues could be resolved.

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