News
IVF cycles rise across Europe, as more couples struggle to conceive
European clinics delivered more than one million IVF cycles in 2021, new figures show
Women in Europe are receiving more cycles of in vitro fertilisation (IVF) and intrauterine insemination (IUI), new data has shown.
Preliminary data from the ESHRE European IVF Monitoring (EIM) Consortium has revealed a steady and progressive rise in the use of assisted reproductive technology (ART).
The findings, presented at the ESHRE 40th annual meeting in Amsterdam, showed that a total of 1,103,633 ART treatment cycles were reported by 1,382 clinics across 37 European countries in 2021, a 20 per cent increase from 2020.
Of these 2021 treatment cycles, 153,191 were IVF, 418,069 intracytoplasmic sperm injection (ICSI), 368,464 frozen embryo replacement, 78,432 preimplantation genetic testing, 79,510 egg donations, 415 in vitro maturation of oocytes, and 5,552 cycles with frozen oocyte replacement.
In addition, data from 1,441 institutions reported 148,194 IUI treatments where the partner’s semen is used (31 countries) and 48,583 IUI treatments where donor semen is used (23 countries).
A total of 28,768 fertility preservation interventions, including oocyte, ovarian tissue, semen, and testicular tissue banking, were reported from 15 countries.
Clinical pregnancy rates per aspiration and per transfer remained similar in 2021 and 2020 for IVF and ICSI.
Pregnancy rates per transfer for frozen embryo replacement with own embryos was slightly higher in 2021, as were pregnancy rates per fresh embryo transfer from egg donations, while for frozen oocyte replacements the number decreased slightly.
This reflects a 3.98 per cent increase in the use of one embryo per transfer, rising from 57.9 per cent in 2020 to 60.5 per cent in 2021.
Lead author Dr Jesper Smeenk of Elisabeth-TweeSteden Hospital in Tilburg, Netherlands, said: “The 25th ESHRE report on ART and IUI shows a continuous increase of reported treatment numbers and medically assisted reproduction (MAR)-derived live births in Europe.
“Being already the largest data collection on MAR in Europe, continuous efforts to stimulate data collection and reporting strive for future quality control and completeness of the data and offer higher transparency and vigilance in the field of reproductive medicine.”
Professor Dr Karen Sermon, chair of ESHRE, added: “This report underscores the significance of collaborative efforts and standardised reporting in advancing reproductive medicine.
“By enhancing data collection practices, we aim to elevate clinical standards and patient outcomes across Europe.”
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Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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