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Comment: Why early lymphedema detection matters for breast cancer survivors

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By Steven Chen, chief medical Officer at medtech firm ImpediMed.

As cancer survival rates continue to climb, healthcare providers must address a critical yet often overlooked long term risk for breast cancer patients and survivors: lymphedema. This condition, characterised by the buildup of protein-rich lymph fluid in tissues, can significantly impact survivors’ quality of life if left undetected and untreated.

This month, as we observe Lymphedema Awareness Month, it’s crucial to highlight the importance of managing this potential side effect of breast cancer care.

Dr Steven Chen, chief medical Officer, ImpediMe

Lymphedema extends far beyond simple swelling. When normal lymphatic drainage is disrupted, it leads to stagnant lymphatic flow and an impaired immune response, potentially resulting in serious complications like cellulitis, a dangerous bacterial skin infection.

The condition also carries a substantial financial burden, with management costs ranging from US$14,877 to US$23,167 over just two years. These figures, coupled with the physical and emotional toll on patients, underscore the urgent need for proactive measures in breast cancer care plans.

Transforming Detection and Prevention

Historically, healthcare providers often waited until lymphedema symptoms became visible and chronic before intervening – often too late for optimal treatment.

Today, technological advances have revolutionised our approach to detection. Bioimpedance Spectroscopy (BIS), recognised in national and international guidelines, can detect lymphedema in under 60 seconds, long before symptoms appear.

BIS was also recently added to the National Accreditation Program for Breast Centers (NAPBC) standards as an evidence-based guideline, requiring accredited programs to adopt proactive, guideline-driven survivorship care—further advancing early detection and prevention.

BIS works by sending a small electrical current through the body, measuring the resistance and reactance to this current. This non-invasive approach enables precise measurement of extracellular fluid and total body water, helping determine intracellular fluid, fat mass, and fat-free mass.

The technology’s sensitivity to small fluid changes allows for earlier detection compared to traditional tape measurements, making it an invaluable tool in detecting lymphedema early enough to decrease the risk of chronic lymphedema.

A Comprehensive Approach to Care

The key to managing lymphedema lies in implementing a robust surveillance program that begins before cancer treatment starts. It is recommended that patients establish baseline measurements using BIS technology and maintain regular monitoring throughout and following the completion of cancer treatment for at least three years.

This proactive approach allows for immediate intervention when subclinical changes are detected, often preventing progression to chronic lymphedema.

Physical wellness forms the foundation of effective lymphedema management. Patients can benefit from customised exercise programs that maintain limb mobility and function, while proper skin care prevents infections that could compromise the lymphatic system.

Regular hydration and stress management could also play crucial roles in maintaining lymphatic health. When indicated, compression garments provide essential support in managing symptoms and preventing progression.

Beyond Physical Care

Effective lymphedema management must consider the patient’s entire life context. Healthcare providers should focus on integrating care strategies into patients’ daily routines, considering their work environments, family responsibilities, and personal goals.

This comprehensive approach includes providing access to support resources, educational materials about lifestyle modifications, and tools for self-monitoring and management.

Digital platforms have emerged as valuable resources, offering educational content, exercise programs, and virtual support communities. These tools empower patients to actively participate in their care while maintaining connections with healthcare providers and fellow survivors. The integration of technology into care plans helps ensure consistent monitoring and early intervention when needed.

The Future of Lymphedema Care

As breast cancer treatment continues to improve, our focus must expand beyond survival to encompass the quality of life during and after treatment. The implementation of routine BIS screening represents a step forward in protecting patients from the devastating effects of chronic lymphedema.

Early detection is the key to early intervention, which is the best chance to prevent chronic problems that may require lifelong intensive treatment.

Physicians and other healthcare providers should initiate conversations about lymphedema risk early in the treatment process, making it a routine part of the comprehensive, holistic care of cancer patients.

This early education helps patients understand their risks, encourages them to ask questions about their individual risk factors and early warning signs, reduces unnecessary fear, and empowers them to participate actively in prevention strategies.

The management of lymphedema requires a delicate balance of physical care, emotional support, and lifestyle adaptation. By considering the whole person – their physical needs, emotional well-being, and life circumstances – we can develop more effective, personalized care plans that support long-term health and wellness.

This Lymphedema Awareness Month serves as a reminder that early detection and intervention are crucial in preventing chronic lymphedema. With modern technology and comprehensive care approaches, we have the tools to address this silent threat effectively. By implementing these resources consistently and proactively, we can help ensure that breast cancer survivors not only survive but thrive in their cancer-free lives.

Steven Chen, MD, MBA, serves as the Chief Medical Officer of medical technology company ImpediMed.  Previously, Dr. Chen was the chief medical officer for Avelas Biosciences. He has also served as the chief of breast surgery at UC Davis Medical Center, followed by a position as an associate professor of surgery and as the associate programme director of the surgical oncology training programme at City of Hope National Medical Center in Duarte, California. Dr. Chen is a past president of the American Society of Breast Surgeons and serves on committees for a number of professional societies including the American Medical Association, the Society of Surgical Oncology, and the American College of Surgeons. He is also a practicing surgeon in San Diego, California, and the Director of Surgical Oncology at OasisMD. 

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Research project of the year shortlist revealed

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The Femtech World Awards is proud to reveal the shortlist for Research Project of the Year as part of the third annual global celebration of innovation, impact and leadership across women’s health.

From fertility science and perimenopause research to regional ecosystem analysis, the shortlisted projects reflect the breadth and growing influence of femtech research worldwide.

The category is sponsored by OncoGenomX, with the winner to be selected by a representative from the organisation.

OncoGenomX is dedicated to offering solutions and providing comprehensive support services that empower Drug Developers, Clinical Researchers, Oncologists,NextGenSeq Diagnostics Laboratories, NextGenSeq Service Organisations, Cancer Diagnostics and Therapeutics Companies to achieve their ambitious goals

The shortlisted entries for Research Project of the Year are:

Women’s health remains significantly underserved in South-East Asia, with persistent gaps in access, awareness, and quality of care carrying substantial social and economic costs.

This report examines the femtech landscape in Indonesia, the Philippines, Singapore, Thailand, and Vietnam, highlighting market trends, emerging technologies including artificial intelligence, and the evolving support ecosystem.

It identifies key challenges facing femtech founders, including limited access to finance, low awareness and persistent stigma, marketing constraints linked to content moderation, and gaps in tailored ecosystem support.

 

Led by Stephanie Willson, MD, of the IVI RMA Global Research Alliance, the study explored whether embryos that show certain chromosome abnormalities during genetic testing may still have the potential to result in a healthy pregnancy and live birth.

The research analysed more than 7,600 frozen embryo transfers and found that some embryos previously considered unlikely to succeed were still capable of leading to successful pregnancies, although at lower rates than embryos without abnormalities.

The findings could help fertility clinics and patients make more informed decisions during IVF treatment, particularly in cases where there are limited embryos available.

Rather than automatically discarding these embryos, the research supports a more evidence-based and personalised approach to fertility care.

For many women, perimenopause can feel confusing and unpredictable, with limited research explaining what is happening in their bodies.

Natural Cycles set out to change that by leading one of the largest studies ever conducted on menstrual and ovulatory patterns, uncovering new insights into how ovulation behaves as women approach menopause.

Conducted in collaboration with researchers from George Washington University, Seattle Clinical Research Center, Gennev and the University of California San Diego, the study analysed nearly one million menstrual cycles from more than 197,000 women aged 18–52 across more than 140 countries.

The scale of this dataset made it possible to explore menstrual patterns and ovulation in far greater detail than has traditionally been possible in women’s health research.

The Femtech World Awards celebrates the innovators, researchers and organisations driving meaningful progress in women’s health.

What happens next

Winners across all categories will be revealed during the virtual ceremony on June 19, with winners receiving a trophy and an interview with a Femtech World journalist.

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Mental health

Women over 40 seeking raves for mental health benefits

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Women over 40 are seeking raves for mental and physical wellbeing, with a study suggesting the benefits go beyond nightlife.

The findings challenge the idea that nightlife and electronic dance music events are mainly for younger people.

Published in Psychology of Music, the study focused on the common misconception that nightlife is only for younger audiences.

Researchers surveyed 136 female clubbers aged 40 to 65 about their experiences at electronic dance music events.

The study, carried out at the University of Leeds in England, found women reported mental and physical wellbeing benefits from attending these events.

Seeing favourite DJs was the most common motivation, but many women also described dancing as a way to relieve stress and find emotional support.

The research found that 65.9 per cent of participants described attending a rave as “spiritual”, while 62.9 per cent said it offered an escape from everyday life.

A further 58.3 per cent said they felt like a different version of themselves in a club environment.

Nine in ten participants said they felt at home at electronic dance music events, with many pointing to a shared passion for music and the sense of community around it.

The study also suggested physical fitness played a role, with some women saying they had made clubbing part of their regular exercise routine.

However, the findings also highlighted challenges for older women in nightlife spaces.

One fifth of participants said they felt visibly out of place because of their age.

Nearly half reported unwanted physical contact, leading some to seek out different venues or attend only with friends.

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Osteoporosis significantly increases risk of death in menopause, study suggests

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Osteoporosis may raise the risk of death in postmenopausal women by up to 47 per cent, a new study suggests.

The findings point to an inverse relationship between femoral bone mineral density and mortality risk, especially within certain ranges.

Femoral bone mineral density is the amount of mineral in the thigh bone, which is often measured to assess bone strength and osteoporosis risk.

Dr Monica Christmas is associate medical director for The Menopause Society.

She said: “Osteoporosis often remains a silent threat after menopause, despite its profound effect on women’s lives—from loss of height, poor balance, and reduced mobility to disfigurement, pain, and even premature death.

“Early screening and preventive measures, including a calcium-rich diet (preferably from food sources), regular weight-bearing exercise, and hormone therapy when appropriate, can significantly improve bone health and reduce risks not only of fractures but also cardiovascular disease, certain cancers, and dementia.

“It’s time we bring this conversation to the forefront.”

In the  study involving nearly 3,000 postmenopausal women, bone mineral density at four femoral sites was assessed using dual-energy x-ray absorptiometry, a scan commonly used to measure bone strength and fracture risk.

The analysis found that mortality risk was significantly higher when femoral bone mineral density reached the osteoporotic threshold or when osteoporotic fractures were present.

After full adjustment, osteoporosis was associated with a 47 per cent increased risk of mortality.

A stronger inverse association between increased bone mineral density and mortality risk was seen within specific ranges, suggesting bone mineral density could serve as a prognostic marker of wider health.

The relationship appeared especially notable within the range of 0.46 to 0.71 g/cm² for total femur bone mineral density.

Previous research has shown that postmenopausal women face a significantly higher risk of death within one year of hip or vertebral fractures.

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