Connect with us

News

Comment: How cutting-edge femtech can remove the barriers to IVF and close the fertility gap

Published

on

Hans Gangeskar, CEO of Overture Life, on harnessing lab automation to make IVF more accessible.

As infertility rates continue to rise globally, in vitro fertilisation (IVF) is an increasingly critical aspect of women’s health and reproductive freedom.

The promise that women should be able to choose when and if to have a baby remains unfulfilled without radical technological advances in IVF both to improve outcomes and to reduce prices. At current costs and success rates, IVF remains out of reach for most women due to cost and emotional burden.

IVF has recently reentered the political arena in the US, where most women must pay out of pocket for an IVF cycle can cost in excess of $20,000 (£15,800), and on average it takes 2.5 cycles to have a baby, driving the average cost of an IVF baby to around $50,000 (£39,500).

This is obviously out of reach in most cases. The conversation has centered around better insurance coverage, but that cannot address the underlying lack of capacity. IVF is supply constrained because there are not enough IVF clinics and embryology labs to meet current demand.

Overture Life CEO Hans Gangeskar

The key to expanding access, in the US and globally, is to bring down the cost of each cycle, and drastically reduce the number of cycles necessary.

We need the opposite of the development we have seen in the rest of healthcare, where the price of services increases much faster than inflation.

Driving prices down and quality up to make IVF affordable requires new technology, standardisation and automation.

The costs of infertility and IVF are not just financial, and for many couples the burden of a failed cycle and the stress of the high financial burden combine to reach a threshold where they give up.

Researchers and experts around the world continue to tell us why fertility rates are dropping. Reasons cited range from expense of child rearing, forever chemicals, diseases like cancer and long covid and more.

It is however very clear to us that the time when women want to have children has changed, and this is an area where technology can come in and deliver more reproductive freedom to address fertility obstacles head-on.

Globally, only a fraction of fertility service demand is met, and new technology must deliver lower costs but also better results. Even successful IVF generally takes multiple attempts, with attendant stresses on physical and mental health – 80% of IVF patients report symptoms of clinical depression.

Cutting-edge femtech has the ability to address the fertility gap in novel ways, especially by modernising and miniaturising the embryology lab.

Shrinking costs

One of the main drivers of the high price tag is embryology laboratory expenses, which can account for half of all IVF costs, limiting access in several ways. First, many procedures done today are still manual, resembling ones used 45 years ago. This limits viability rates, driving up the number of cycles needed for a successful IVF.

It also means the procedures remain complex, requiring highly trained staff who are in high demand. This in turn helps make it cost-prohibitive for small facilities to fully staff an embryology lab, thereby capping availability – and over 5 million women in the UK now have limited or no access to local fertility clinics.

Bringing IVF costs down is primarily a question of opening more points of care. We need to make it possible to offer IVF services alongside other medical services making it economically viable to serve only 100 IVF cycles per year, or even as low as 20.

Technology is beginning to enable this potential. In addition, the promise of automation is not just efficiency, it is the ability to standardise and iterate. And this isn’t just the ability to standardize across an industry, but to standardize between shifts in a single clinic.

IVF clinics have pioneered many advances in the field, but it is also a very manual and artisanal practice, making it hard to copy processes from one embryologist to another, let alone from one clinic to the next.

Automated technology helps standardise steps like egg freezing, intracytoplasmic sperm injection (ICSI), and embryo selection, which are prone to human error.

Together, these platforms have been shown to improve viability rates meaningfully – a huge cost savings for patients. It can also shrink the required overhead for a small facility by an order of magnitude, further lowering costs while expanding access.

An automated world

Bringing IVF services to fertility deserts first and foremost requires portability. Microfluidics, a technology popularised in medtech to bring complex processes closer to the point of care, is important for both shrinking and automating vitrification – the freezing and thawing of eggs and embryos.

Because it is a more gentle way of handling cells (eggs), microfluidics reduces osmotic stress on fragile cells, minimising egg and embryo loss. It also enables small, powerful automated devices.

Robotics is also key for any automation paradigm, generally reducing both handling time and process complexity. There is a prime opportunity for improvement when making an embryo, the most challenging task in an embryology lab.

Technology is now in use that can automate the technique known as Piezo-ICSI, a gentle and precise method to inject sperm into an egg that improves both fertilisation and blastocyst development.

Robotic ICSI has already resulted in two live births and has been shown to increase fertilisation rates to 93 per cent, compared to 89 per cent for manual methods.

Of course, the consistency of robotics also removes the potential for human variability and error, removing the potential for fatigue.

Anecdotally, some IVF clinics have noted lower success rates when complex manual procedures are performed by embryologists late in the day.

A robotic platform can also reduce inconsistency between embryologists and between labs, which translate into more consistent, better outcomes.

The third critical piece for automation excellence is advanced analytics, especially when paired with AI techniques. Technology has been deployed to improve on standard preimplantation genetic testing (PGT), which helps identify and select embryos without genetic disease.

However, standard PGT predicts embryo implantation at just 60%, leaving plenty of room for improvement. It also relies on a biopsy to remove cells from the embryo, which carries a small risk of damaging it.

Newer methods utilize metabolomics powered by machine learning. These platforms have been shown to improve implantation prediction accuracy above 80%, and can identify and discard 90% of aneuploid embryos (with chromosomal abnormalities). Because only metabolites produced by the embryo, no invasive biopsy is required, reducing the demand on embryologists while helping to identify stronger embryos.

Given the significant and growing fertility challenges around the world, and the notable gaps in access to treatment driven by cost and geography, it’s clear that we in the fertility field need to do a better job of reaching women everywhere. Because labwork is not patient-facing, its impact can be broadly underestimated or even ignored.

However, the reality is that there are multiple opportunities to improve the embryology lab through automation, improving outcomes and ensuring embryologists can spend more time with more patients.

Hans Gangeskar is CEO of Overture Life, which aims to simplify and automate the complex processes of embryology.

Pregnancy

More than half of women with gestational diabetes face harmful stigma, research reveals

Published

on

More than half of women with gestational diabetes report stigma from healthcare staff, family, friends and wider society, new research shows.

A survey of 1,800 UK women found widespread emotional distress at diagnosis of the condition, a form of high blood sugar that develops during pregnancy, with effects lasting beyond birth.

Gestational diabetes affects around one in 20 pregnancies in the UK, and the findings highlight the wider toll on women diagnosed with the condition.

The study was funded by Diabetes UK and led by researchers at King’s College London and University College Cork.

Dr Elizabeth Robertson, director of research and clinical at Diabetes UK, said: “Stigma can have a dangerous and devastating impact on pregnant women diagnosed with gestational diabetes, particularly at a time when emotions and anxieties may already be heightened.

“We know that stigma can lead to shame, isolation and poorer mental health, and may discourage people from attending healthcare appointments, potentially increasing the risk of serious complications.

“This research highlights the urgent need for better support systems, based on understanding and empathy to ensure no one feels blamed or judged during their pregnancy.”

More than two-thirds of women, 68 per cent, reported anxiety at diagnosis, while 58 per cent felt upset and 48 per cent experienced fear.

The psychological impact continued beyond birth, with 61 per cent saying the condition negatively affected their feelings about future pregnancies.

Nearly half of women, 49 per cent, felt judged for having gestational diabetes, while 47 per cent felt judged because of their body size.

More than 80 per cent felt other people did not understand gestational diabetes, and more than a third, 36 per cent, concealed their diagnosis from others.

Gestational diabetes stigma was also common in healthcare settings, with 48 per cent reporting that professionals made assumptions about their diet and exercise, and more than half, 52 per cent, feeling judged based on their blood glucose results.

Many women described a loss of control and a sense of disruption during pregnancy.

Nearly two-thirds, 64 per cent, felt they were denied a normal pregnancy, while 76 per cent reported a lack of control over their pregnancy.

More than a third, 36 per cent, felt abandoned by healthcare services after giving birth, and one in four, 25 per cent, continued to experience depression or anxiety postpartum.

Focus group participants described harmful stereotypes, including assumptions that they were ‘lazy’, had ‘poor eating habits’ or ‘lacked willpower’.

Comments from family and friends included remarks such as “should you be eating that?” and “you must have eaten too much, that’s why you have gestational diabetes.”

The researchers are calling for targeted interventions alongside structured emotional support for women during and after pregnancies affected by gestational diabetes, to improve both mental and physical health outcomes.

Professor Angus Forbes, lead researcher from King’s College London, said: “Stigma and emotional distress are far more common in women diagnosed with gestational diabetes than many realise.

“Everyday interactions, even with those who mean well, can deepen this harm, shaping women’s emotional wellbeing and the choices they feel able to make.

“It’s clear that meaningful action is needed to protect women’s mental and physical health.”

Risk factors for gestational diabetes include living with overweight or obesity, having a family history of type 2 diabetes, and being from a South Asian, Black or African Caribbean or Middle Eastern background.

Continue Reading

Pregnancy

NIPT or NT scan? Why the 2026 evidence supports doing Both

Published

on

Article produced in association with London Pregnancy Clinic

One of the most common questions in early pregnancy: NIPT or the nuchal translucency (NT) scan – do I really need both? The 2026 evidence gives a clear answer.

The two tests look at different things, and doing them together is how first-trimester screening works at its best.

This is not a debate between old and new technology. NIPT is a genuine advance in detecting chromosome abnormalities from a maternal blood sample.

The NT scan is the first detailed look at how the fetus is forming. What each sees, the other largely cannot.

What NIPT actually tells you

NIPT – non-invasive prenatal testing – analyses fragments of fetal DNA circulating in the mother’s blood. Taken from around 10 weeks, the test measures chromosome proportions to flag the common trisomies: trisomy 21 (Down syndrome), trisomy 18 (Edwards) and trisomy 13 (Patau).

Most panels include fetal sex and sex-chromosome aneuploidies. Extended NIPT adds selected microdeletion syndromes – most commonly 22q11.2 (DiGeorge syndrome) – and the newest whole-genome platforms can detect copy-number variants down to around 1 Mb across every chromosome.

What NIPT does not look at is anatomy. It tells you whether the chromosomes are numerically correct.

It cannot tell you how the heart, brain, spine, kidneys or abdominal wall are forming, because it analyses DNA, not structure.

The NHS offers NIPT as a second-line screening test, reserved for women who receive a higher-chance result from the combined test – precisely because NIPT is best understood as one part of a wider screening picture rather than the whole of it.

What the NT scan actually tells you

The NT scan is an ultrasound performed at 11 to 14 weeks that measures the nuchal translucency – a small fluid-filled space at the back of the fetal neck.

Protocols developed by the Fetal Medicine Foundation, the group that pioneered first-trimester screening under Professor Kypros Nicolaides at King’s College Hospital, combine the NT measurement with additional markers: nasal bone, ductus venosus flow, tricuspid regurgitation, and maternal serum biomarkers (PAPP-A and free β-hCG).

More importantly, the scan is the first structural assessment of the fetus.

Major anomalies already visible at 11-14 weeks include absence of the cranial vault, large body-wall defects such as omphalocele and gastroschisis, megacystis, severe cardiac defects with abnormal four-chamber views, and skeletal dysplasias.

An increased NT measurement itself – even with a completely normal chromosome result – is associated with a notable rate of structural heart defects and monogenic syndromes that NIPT cannot detect.

Why the combination outperforms either test alone

Taken together, NIPT and the NT scan give complementary coverage.

For the common trisomies, NIPT is more sensitive than the NT scan alone. Pooled data place detection of trisomy 21 above 99 per cent with a false-positive rate around 0.1 per cent.

Combined first-trimester screening without NIPT, using NT and serum markers alone, reaches approximately 90 per cent detection – and up to 95 per cent when nasal bone, ductus venosus and tricuspid flow are added – at a 3 to 5 per cent false-positive rate.

For that specific endpoint, NIPT is the more accurate test.

The NT scan picks up almost everything NIPT misses: structural anomalies, early markers of monogenic syndromes, confirmation of viability, accurate dating, twin chorionicity, and placental position.

An increased NT with a normal NIPT result shifts the clinical conversation toward syndromes like Noonan, Kabuki and the skeletal dysplasias – conditions with single-gene origins rather than chromosomal ones.

Working out which is which often requires genetic testing beyond NIPT. Carrier screening and expanded genetic panels – including those offered at Jeen Health – cover the single-gene territory that NIPT does not address.

When the combination matters most

Several patient groups have most to gain from doing both:

  • Women conceiving after IVF or with donor gametes, where maternal age and fertility treatment each subtly shift risk profiles
  • Women aged 35 and over, where baseline chromosomal risk is higher and soft markers are more likely
  • Anyone with a previous pregnancy affected by an anomaly or loss, where reassurance matters
  • Twin pregnancies, where NIPT performance depends on fetal fraction and structural assessment is more complex
  • Women who have had a raised or borderline result on earlier screening markers

Chromosomes and anatomy are two separate clinical questions. Each needs its own answer.

What happens if the tests disagree

Disagreements between NIPT and the NT scan are not failures of either test – they are the reason both are done.

  • NIPT low-risk, NT raised: consider monogenic syndromes, structural cardiac assessment, and early anomaly ultrasound follow-up
  • NIPT higher-chance, scan normal: confirmatory diagnostic testing (CVS or amniocentesis) before any major decision
  • NIPT no-call: repeat sampling, gestational age check and clinical review – a no-call itself is associated with an increased chromosomal risk
  • Both abnormal: a clear indication for specialist fetal medicine review and early diagnostic testing

Professional guidance from the RCOG supports this complementary approach, emphasising that NIPT is a screening rather than a diagnostic test, and that its results are most useful when interpreted alongside ultrasound findings.

Practical guidance for 2026

The most efficient way to run both tests is in a single appointment window, between 10 and 14 weeks, with the blood sample taken first and the scan performed on the same visit.

Results typically return within 5 to 10 working days for standard NIPT panels, and same-day for the scan itself.

This is the logic behind the SMART Test at London Pregnancy Clinic – extended NIPT paired with a full first-trimester ultrasound in a single appointment, delivering both chromosomal and structural information in one visit. For most patients, it removes the false choice of picking one over the other.

The wider picture

The question of NIPT versus NT scan has a settled clinical answer in 2026: the two tests examine different aspects of the pregnancy, and the most complete first-trimester assessment uses both.

For a pregnancy a woman wants to carry with the fullest possible picture, both tests belong in the first-trimester window. The question worth asking is which clinic offers them together, with the pre- and post-test care that makes the results usable.

If you are deciding on first-trimester screening, a consultation with a fetal medicine specialist is the most useful first step.

Disclaimer: This article is produced for informational purposes only and does not constitute medical advice, diagnosis or treatment. Clinical guidance referenced reflects published NHS, Fetal Medicine Foundation and RCOG standards as at April 2026. Individual circumstances vary; readers are advised to consult a qualified healthcare professional before acting on any information in this article. This piece was produced in association with London Pregnancy Clinic, which provided background clinical information for editorial purposes. Hyperlinks to external sources are included for reference only and do not represent an endorsement of any product, service or organisation.

Continue Reading

Diagnosis

New meta-analysis further supports low re-excisions and high placement accuracy with the Magseed marker

Published

on

An independent meta-analysis from January 2026, pooling 2,117 patients and 2,176 Magseed marker placements, has reported low re-excision rates (8.2%) and low positive margins (7.6%) when the marker is used to localise non-palpable breast lesions prior to breast‑conserving surgery (BCS).

Al Darwashi et al. (2026) pooled 16 studies to evaluate safety and efficacy outcomes when the Magseed marker was used for preoperative localisation of non-palpable lesions prior to BCS.

The authors reported high placement accuracy, reliable intraoperative retrieval and low rates of positive margins, re-excisions and complications.

In a cohort cited by the review, Moreno‑Palacios et al. (2024) also observed that Magseed marker facilitates less extensive resections compared to guidewires, promising improved cosmetic outcomes while maintaining oncological efficacy.

The key findings

Low re-operation burden: Positive margins occurred in just 7.6% of cases, and only 8.2% required re-excision across the included series.

High placement accuracy: The success rate for Magseed marker placement showed 99.3% positioned within 10 mm of the lesion.

Of note, 96.6% of Magseed markers were placed within an even stricter 5 mm radius.

Reliable retrieval: The pooled intraoperative retrieval success was 99.6% for the Magseed® marker.

“This meta-analysis demonstrated Magseed as a safe and effective preoperative localisation technique for BCS in the management of selected non-palpable breast lesions.” Al Darwashi et al. (2026)

Ready to find out more about the Magseed marker and the Sentimag system?

→ Speak to a Magseed marker expert

→ Read the full paper here

Magseed® is a trademark of Hologic, Inc. or its subsidiaries in the United States or other countries. Intended for medical professionals and use in the U.S., UK and the EU only.

Continue Reading

Trending

Copyright © 2025 Aspect Health Media Ltd. All Rights Reserved.