News
Research roundup: biodegradable contraceptive to be developed, impact of the microbiome on fertility and more

Femtech World explores the latest research developments in the world of women’s health.
Screening and treating maternal psychological health key to improving cardiovascular health
Integrating routine psychological health screening and treatment during and after pregnancy may reduce the risk of adverse pregnancy outcomes and improve maternal cardiovascular health, according to a new scientific statement.
The statement highlights the need to support maternal cardiovascular health by including comprehensive screening of psychological health during the perinatal period (pregnancy through one year postpartum). Cardiovascular issues are the number one cause of maternal death.
The statement summarises the evidence associating psychological health concerns and adverse cardiovascular outcomes; highlights effective management strategies and integrated care delivery models; and identifies current challenges and future directions for improving maternal health outcomes.
Young women suffering menopause symptoms in silence
More than half of women ages 30 to 35 are already suffering moderate to severe symptoms associated with menopause, yet most women are waiting decades before seeking treatment, new research from UVA Health and the Flo women’s health app reveals.
The research sheds important light on “perimenopause,” the transition period leading to menopause.
Many women in perimenopause assume they’re too young to be suffering symptoms related to menopause, believing that symptoms won’t appear until they reach their 50s. But this mistaken belief, the researchers say, only causes women to suffer in silence.
The new study analysed symptoms self-reported by more than 4,400 American women ages 30 and older who responded to a survey conducted online and in the Flo app.
Among women 30 to 35, 55.4 per cent reported symptoms that meet the criteria for “moderate” or “severe” on the widely used Menopause Rating Scale (MRS). This number increased to 64.3 per cent among women 36 to 40. Yet most women don’t seek treatment for menopause symptoms until they are 56 or older.
Transforming age-related health conditions with new class of medical foods
Solarea Bio has introduced its consumer health brand, Journa, to improve the ageing experience with natural, clinically validated solutions – including age-related health conditions such as postmenopausal bone loss and chronic autoimmune diseases.
Journa’s proprietary platform, Microscape Technology is an AI-driven product engine that enables faster commercialisation of products in the pipeline.
Expert scientists can quickly isolate microbes naturally found in fruits, vegetables, and fermented foods, sequencing the full genome of each isolate for a comprehensive microbial library. This library includes over 5,000 microbial isolates, more than 16 million genes, and over seven million biosynthetic clusters.
Journa has now enabled early access to its scientifically formulated daily synbiotic medical food, Bondia (SBD111), designed to aid in the dietary management of bone loss associated with osteopenia, menopause, weight, and age.
The product specifically targets bone loss, which disproportionately affects women in cases of osteopenia and osteoporosis.
How the microbiome influences female fertility
A diverse microbiome that may influence fertility and reproductive health. A new review has explored how microbial communities in the female reproductive tract, especially Lactobacillus spp., affect embryo implantation, pregnancy success, and gynaecological diseases.
Researchers found that a Lactobacillus-dominated (LD) uterine environment significantly improves pregnancy outcomes. Similarly, pregnancy success rates were higher in LD environments.
Lactobacilli help by maintaining a low pH in the reproductive tract, preventing harmful bacteria (like E. coli) from taking over. Other microbes, such as Bifidobacterium spp. (acetate producer), Prevotella spp. (acetate producer), Eubacterium spp. (Butyrate producer) and Enterobacter spp. (propionate producer), may play a role, producing short-chain fatty acids (SCFAs) that regulate immune responses crucial for embryo implantation.
The study highlights that women undergoing IVF who had a non-LD uterine microbiome were far less likely to achieve pregnancy. Additionally, disruptions in microbiota composition have been linked to conditions such as chronic endometritis, endometriosis, and recurrent implantation failure (RIF).
These findings underscore the need for more targeted fertility treatments, including microbiome-based interventions. The researchers suggest that probiotics or personalized treatments to restore a healthy microbiome could improve fertility outcomes, particularly for women struggling with IVF failure.
Biodegradable long-acting contraceptive implant to be developed
Daré Bioscience and Theramex have announced that they have entered into a co-development and licensing agreement for a potential first-in-category biodegradable contraceptive implant called Casea S recently acquired by Theramex.
An ongoing Phase 1 study is funded by a foundation grant, and is being conducted by FHI 360 to investigate pharmacokinetics, removability, safety and tolerability of Casea S.
The biodegradable implant is designed to control release of a well-characterised contraceptive for a set period of time of 18 to 24 months before dissolving. It is designed to provide women with a long-acting, minimally-invasive contraceptive method that will not require surgical removal by a healthcare provider, which would improve convenience and could eliminate one of the barriers to use associated with existing implanted contraceptives.
Women’s telehealth brand, PeachesRx, launches to focus on GLP-1 weight loss treatments
Mangoceuticals, a company focused on developing, marketing, and selling a variety of men’s wellness products via a secure telemedicine platform under the brand MangoRx, has announced the official launch of PeachesRx.
The women’s health and wellness brand will focus on providing cutting-edge, convenient treatments tailored to women’s unique health needs that will be made available via a secure telemedicine platform.
PeachesRx will focus on compounded GLP-1 receptor agonists – a class of medications proven to aid weight loss by regulating appetite and glucose metabolism. By introducing its tailored GLP-1 offerings, PeachesRx aims to meet the unique metabolic needs of women while providing an accessible and affordable telehealth-driven solution.
Heart disease and stroke risk may increase from gynecological conditions
A new study has revealed that having a gynecological disorder may be linked to an increased risk of heart disease and stroke.
According to the researchers, women’s risk of ischaemic heart disease was 41 per cent higher if a gynecological condition was present, while cerebrovascular disease risk was 33 per cent higher.
The team say the risk factors may be contributed to from biological pathways such as systemic inflammation and oestrogen production.
Pregnancy
More than half of women with gestational diabetes face harmful stigma, research reveals

More than half of women with gestational diabetes report stigma from healthcare staff, family, friends and wider society, new research shows.
A survey of 1,800 UK women found widespread emotional distress at diagnosis of the condition, a form of high blood sugar that develops during pregnancy, with effects lasting beyond birth.
Gestational diabetes affects around one in 20 pregnancies in the UK, and the findings highlight the wider toll on women diagnosed with the condition.
The study was funded by Diabetes UK and led by researchers at King’s College London and University College Cork.
Dr Elizabeth Robertson, director of research and clinical at Diabetes UK, said: “Stigma can have a dangerous and devastating impact on pregnant women diagnosed with gestational diabetes, particularly at a time when emotions and anxieties may already be heightened.
“We know that stigma can lead to shame, isolation and poorer mental health, and may discourage people from attending healthcare appointments, potentially increasing the risk of serious complications.
“This research highlights the urgent need for better support systems, based on understanding and empathy to ensure no one feels blamed or judged during their pregnancy.”
More than two-thirds of women, 68 per cent, reported anxiety at diagnosis, while 58 per cent felt upset and 48 per cent experienced fear.
The psychological impact continued beyond birth, with 61 per cent saying the condition negatively affected their feelings about future pregnancies.
Nearly half of women, 49 per cent, felt judged for having gestational diabetes, while 47 per cent felt judged because of their body size.
More than 80 per cent felt other people did not understand gestational diabetes, and more than a third, 36 per cent, concealed their diagnosis from others.
Gestational diabetes stigma was also common in healthcare settings, with 48 per cent reporting that professionals made assumptions about their diet and exercise, and more than half, 52 per cent, feeling judged based on their blood glucose results.
Many women described a loss of control and a sense of disruption during pregnancy.
Nearly two-thirds, 64 per cent, felt they were denied a normal pregnancy, while 76 per cent reported a lack of control over their pregnancy.
More than a third, 36 per cent, felt abandoned by healthcare services after giving birth, and one in four, 25 per cent, continued to experience depression or anxiety postpartum.
Focus group participants described harmful stereotypes, including assumptions that they were ‘lazy’, had ‘poor eating habits’ or ‘lacked willpower’.
Comments from family and friends included remarks such as “should you be eating that?” and “you must have eaten too much, that’s why you have gestational diabetes.”
The researchers are calling for targeted interventions alongside structured emotional support for women during and after pregnancies affected by gestational diabetes, to improve both mental and physical health outcomes.
Professor Angus Forbes, lead researcher from King’s College London, said: “Stigma and emotional distress are far more common in women diagnosed with gestational diabetes than many realise.
“Everyday interactions, even with those who mean well, can deepen this harm, shaping women’s emotional wellbeing and the choices they feel able to make.
“It’s clear that meaningful action is needed to protect women’s mental and physical health.”
Risk factors for gestational diabetes include living with overweight or obesity, having a family history of type 2 diabetes, and being from a South Asian, Black or African Caribbean or Middle Eastern background.
Pregnancy
NIPT or NT scan? Why the 2026 evidence supports doing Both

Article produced in association with London Pregnancy Clinic
One of the most common questions in early pregnancy: NIPT or the nuchal translucency (NT) scan – do I really need both? The 2026 evidence gives a clear answer.
The two tests look at different things, and doing them together is how first-trimester screening works at its best.
This is not a debate between old and new technology. NIPT is a genuine advance in detecting chromosome abnormalities from a maternal blood sample.
The NT scan is the first detailed look at how the fetus is forming. What each sees, the other largely cannot.
What NIPT actually tells you
NIPT – non-invasive prenatal testing – analyses fragments of fetal DNA circulating in the mother’s blood. Taken from around 10 weeks, the test measures chromosome proportions to flag the common trisomies: trisomy 21 (Down syndrome), trisomy 18 (Edwards) and trisomy 13 (Patau).
Most panels include fetal sex and sex-chromosome aneuploidies. Extended NIPT adds selected microdeletion syndromes – most commonly 22q11.2 (DiGeorge syndrome) – and the newest whole-genome platforms can detect copy-number variants down to around 1 Mb across every chromosome.
What NIPT does not look at is anatomy. It tells you whether the chromosomes are numerically correct.
It cannot tell you how the heart, brain, spine, kidneys or abdominal wall are forming, because it analyses DNA, not structure.
The NHS offers NIPT as a second-line screening test, reserved for women who receive a higher-chance result from the combined test – precisely because NIPT is best understood as one part of a wider screening picture rather than the whole of it.
What the NT scan actually tells you
The NT scan is an ultrasound performed at 11 to 14 weeks that measures the nuchal translucency – a small fluid-filled space at the back of the fetal neck.
Protocols developed by the Fetal Medicine Foundation, the group that pioneered first-trimester screening under Professor Kypros Nicolaides at King’s College Hospital, combine the NT measurement with additional markers: nasal bone, ductus venosus flow, tricuspid regurgitation, and maternal serum biomarkers (PAPP-A and free β-hCG).
More importantly, the scan is the first structural assessment of the fetus.
Major anomalies already visible at 11-14 weeks include absence of the cranial vault, large body-wall defects such as omphalocele and gastroschisis, megacystis, severe cardiac defects with abnormal four-chamber views, and skeletal dysplasias.
An increased NT measurement itself – even with a completely normal chromosome result – is associated with a notable rate of structural heart defects and monogenic syndromes that NIPT cannot detect.
Why the combination outperforms either test alone
Taken together, NIPT and the NT scan give complementary coverage.
For the common trisomies, NIPT is more sensitive than the NT scan alone. Pooled data place detection of trisomy 21 above 99 per cent with a false-positive rate around 0.1 per cent.
Combined first-trimester screening without NIPT, using NT and serum markers alone, reaches approximately 90 per cent detection – and up to 95 per cent when nasal bone, ductus venosus and tricuspid flow are added – at a 3 to 5 per cent false-positive rate.
For that specific endpoint, NIPT is the more accurate test.
The NT scan picks up almost everything NIPT misses: structural anomalies, early markers of monogenic syndromes, confirmation of viability, accurate dating, twin chorionicity, and placental position.
An increased NT with a normal NIPT result shifts the clinical conversation toward syndromes like Noonan, Kabuki and the skeletal dysplasias – conditions with single-gene origins rather than chromosomal ones.
Working out which is which often requires genetic testing beyond NIPT. Carrier screening and expanded genetic panels – including those offered at Jeen Health – cover the single-gene territory that NIPT does not address.
When the combination matters most
Several patient groups have most to gain from doing both:
- Women conceiving after IVF or with donor gametes, where maternal age and fertility treatment each subtly shift risk profiles
- Women aged 35 and over, where baseline chromosomal risk is higher and soft markers are more likely
- Anyone with a previous pregnancy affected by an anomaly or loss, where reassurance matters
- Twin pregnancies, where NIPT performance depends on fetal fraction and structural assessment is more complex
- Women who have had a raised or borderline result on earlier screening markers
Chromosomes and anatomy are two separate clinical questions. Each needs its own answer.
What happens if the tests disagree
Disagreements between NIPT and the NT scan are not failures of either test – they are the reason both are done.
- NIPT low-risk, NT raised: consider monogenic syndromes, structural cardiac assessment, and early anomaly ultrasound follow-up
- NIPT higher-chance, scan normal: confirmatory diagnostic testing (CVS or amniocentesis) before any major decision
- NIPT no-call: repeat sampling, gestational age check and clinical review – a no-call itself is associated with an increased chromosomal risk
- Both abnormal: a clear indication for specialist fetal medicine review and early diagnostic testing
Professional guidance from the RCOG supports this complementary approach, emphasising that NIPT is a screening rather than a diagnostic test, and that its results are most useful when interpreted alongside ultrasound findings.
Practical guidance for 2026
The most efficient way to run both tests is in a single appointment window, between 10 and 14 weeks, with the blood sample taken first and the scan performed on the same visit.
Results typically return within 5 to 10 working days for standard NIPT panels, and same-day for the scan itself.
This is the logic behind the SMART Test at London Pregnancy Clinic – extended NIPT paired with a full first-trimester ultrasound in a single appointment, delivering both chromosomal and structural information in one visit. For most patients, it removes the false choice of picking one over the other.
The wider picture
The question of NIPT versus NT scan has a settled clinical answer in 2026: the two tests examine different aspects of the pregnancy, and the most complete first-trimester assessment uses both.
For a pregnancy a woman wants to carry with the fullest possible picture, both tests belong in the first-trimester window. The question worth asking is which clinic offers them together, with the pre- and post-test care that makes the results usable.
If you are deciding on first-trimester screening, a consultation with a fetal medicine specialist is the most useful first step.
Disclaimer: This article is produced for informational purposes only and does not constitute medical advice, diagnosis or treatment. Clinical guidance referenced reflects published NHS, Fetal Medicine Foundation and RCOG standards as at April 2026. Individual circumstances vary; readers are advised to consult a qualified healthcare professional before acting on any information in this article. This piece was produced in association with London Pregnancy Clinic, which provided background clinical information for editorial purposes. Hyperlinks to external sources are included for reference only and do not represent an endorsement of any product, service or organisation.
Diagnosis
New meta-analysis further supports low re-excisions and high placement accuracy with the Magseed marker

An independent meta-analysis from January 2026, pooling 2,117 patients and 2,176 Magseed marker placements, has reported low re-excision rates (8.2%) and low positive margins (7.6%) when the marker is used to localise non-palpable breast lesions prior to breast‑conserving surgery (BCS).
Al Darwashi et al. (2026) pooled 16 studies to evaluate safety and efficacy outcomes when the Magseed marker was used for preoperative localisation of non-palpable lesions prior to BCS.
The authors reported high placement accuracy, reliable intraoperative retrieval and low rates of positive margins, re-excisions and complications.
In a cohort cited by the review, Moreno‑Palacios et al. (2024) also observed that Magseed marker facilitates less extensive resections compared to guidewires, promising improved cosmetic outcomes while maintaining oncological efficacy.
The key findings
Low re-operation burden: Positive margins occurred in just 7.6% of cases, and only 8.2% required re-excision across the included series.
High placement accuracy: The success rate for Magseed marker placement showed 99.3% positioned within 10 mm of the lesion.
Of note, 96.6% of Magseed markers were placed within an even stricter 5 mm radius.
Reliable retrieval: The pooled intraoperative retrieval success was 99.6% for the Magseed® marker.
“This meta-analysis demonstrated Magseed as a safe and effective preoperative localisation technique for BCS in the management of selected non-palpable breast lesions.” Al Darwashi et al. (2026)
Ready to find out more about the Magseed marker and the Sentimag system?
→ Speak to a Magseed marker expert
Magseed® is a trademark of Hologic, Inc. or its subsidiaries in the United States or other countries. Intended for medical professionals and use in the U.S., UK and the EU only.
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