News
Promising results from ovarian cancer drug study
A combination of two drugs that can block the growth of cancer cells has shown promising results in women with a form of ovarian cancer that rarely responds to chemotherapy or hormone therapy.
Study findings show that in 115 participants with low-grade serous ovarian cancer, 31 per cent saw their tumours shrink or stop growing when taking a combination of avutometinib and defactinib. This is in comparison to a zero to 10 per cent response rate to chemo or hormone therapies in patients with the rare ovarian cancer. Both drugs are designed to block signals that encourage cancer cells to grow.
The new data also shows that only 10 per cent of patients discontinued the trial, demonstrating that the majority of patients could sustain treatment for longer and therefore receive more of the benefits of therapy. In most cases where some side effects affected everyday life, dosage management was employed to limit the impact on patients and ensure that they could continue with treatment.
Professor Susana Banerjee, research lead for the gynecology unit at The Royal Marsden NHS Foundation Trust and Professor in Women’s Cancers at The Institute of Cancer Research, London said: “These are significant results from the second phase of the trial. The toxicities for patients are much lower which means side effects are fewer than with some conventional treatments.
The combination of avutometinib and defactinib promises a new standard of care for people with recurrent low-grade serous ovarian cancer. We’re now looking to recruit patients for our phase three trial and hope results will continue to show better outcomes for patients.”
Responses in patients who had a mutation in a gene called KRAS were even more promising with 44 per cent of patients seeing their tumour shrink. KRAS is one of the most commonly mutated genes in cancer, found in one quarter of all tumors.
Until recently, KRAS-driven tumors were extremely difficult to treat due to their smooth surfaces, making it difficult for small molecules in treatments like chemotherapy to bond to the tumor.
The study will now go to a bigger randomised trial in order to directly compare its efficacy for patients with low-grade serous ovarian cancer against chemotherapy or hormone therapy.
However, clinicians are hopeful that this new drug combination will change practice globally for cases of low-grade serous ovarian cancer and most importantly improve outcomes for patients with limited treatment options.
The new results have led on from the earlier phase I FRAME trial, led by a team at The Institute of Cancer Research (ICR) and The Royal Marsden NHS Foundation Trust, which tested the drugs—called VS-6766 and defactinib—in 25 patients with low-grade serous ovarian cancer. Overall, nearly half (46%) of patients saw their tumors shrink significantly in response to the treatment.
Hormonal health
Medichecks acquires My Menopause Centre to expand specialist hormone health services
Digital diagnostics company Medichecks has acquired specialist menopause health platform and clinic My Menopause Centre.
The deal is part of Medichecks’ move into clinical services and follows its earlier purchase of Leger Clinic, creating what the company describes as a hormone health offering for women and men across the UK.
Medichecks and My Menopause Centre will combine digital services with clinical governance. The acquisition aims to enhance Medichecks’ ability to deliver integrated testing, diagnosis and ongoing clinical support.
The combined group plans to grow its specialist hormone health services, supporting patients across the UK with clinical care throughout different stages of their hormone health journey.
Helen Marsden, co-founder of Medichecks, said: “At Medichecks, our mission is to make healthcare more accessible, evidence-based and patient-centred.
“Helen and Clare have built an outstanding, clinically credible platform that is transforming menopause care for women across the UK.
“Medichecks now owns two CQC Outstanding-rated clinics, the only clinics in their respective sectors to achieve this rating, and we are deeply committed to delivering safe, compassionate and patient-centric care.
“We’re proud to continue the founders’ legacy while supporting the next stage of growth, ensuring more women can access high-quality menopause care when they need it most.”
The CQC, or Care Quality Commission, is the independent regulator of health and social care in England.
The acquisition supports Medichecks’ plans to make hormone healthcare more accessible by delivering integrated testing, diagnosis and ongoing clinical support for patients across the UK.
Helen Normoyle, co-founder and chief executive of My Menopause Centre, said: “We set out to build something resilient, clinically credible and scalable, not just fast.
“Our mission has always been to make menopause care compassionate, accessible and grounded in evidence. Medichecks shares that vision.
“Their digital platform, commitment to clinical excellence and patient-centred care make them the ideal partner to take My Menopause Centre into its next chapter.
“This milestone reflects not only a strong product, but a remarkable team and community.
“I’m deeply proud of what we’ve built and excited to see My Menopause Centre grow further under Medichecks’ leadership.”
Menopause
Menopause specialist Haver joins Midi Health
Menopause specialist Dr Mary Claire Haver has been appointed as the first chief agewell officer at virtual care clinic Midi Health.
In the role, Dr Haver will work with Midi’s clinical team to develop the AgeWell platform, described as a proactive health model that integrates perimenopause and menopausal care with metabolic health, bone density, brain health and cardiovascular risk assessment.
The platform aims to provide preventative care targeting what the company describes as the primary drivers of female mortality and disability: heart disease, bone loss and cognitive decline.
Joanna Strober, chief executive and co-founder of Midi Health, said: “Longevity care has historically ignored women’s biology, especially during the critical windows of midlife and menopause.
“At Midi Health, we are committed to extending healthspan, not just lifespan, and making that care accessible to millions of women as a core pillar of their health.
“By collaborating with Dr Haver, we are ensuring women continue to have access to care designed for their bodies, their hormones, and their real lives.”
Dr Haver is board-certified in obstetrics and gynaecology, a Menopause Society certified practitioner, a certified culinary medicine specialist and an adjunct associate professor of obstetrics and gynaecology at The University of Texas Medical Branch.
After a career in academic medicine, Dr Haver founded The Pause Life, described as a science and education-based resource for women navigating perimenopause and the menopause transition.
Through her books, unPaused podcast and digital platform, she has provided education on midlife health.
Dr Mary Claire Haver said: “I have spent my career advocating for women to receive the science-backed, no-nonsense guidance they deserve.
“I chose to partner with Midi Health because they are the only platform with the scale and medical rigour to deliver the kind of care women deserve, regardless of their zip codes.
“Together, we are setting a new standard for proactive, preventative care that meaningfully extends both lifespan and healthspan for women.”
Entrepreneur
Kate Ryder headlines Women’s Health Week USA 2026 as full agenda goes live
Women’s Health Week USA 2026 has unveiled its first populated agenda, anchored by an opening keynote from Kate Ryder, Founder and CEO of Maven Clinic, and featuring a cross-sector lineup shaping the next phase of scale in women’s health.
You can view the full agenda here.
Taking place May 13–14, 2026, at the New York Academy of Medicine, Women’s Health Week USA brings together the full women’s health ecosystem to focus on one central question: what does it take to move women’s health from innovation to institutional scale?
Kate Ryder will open Day 1 with a keynote drawing on her experience building Maven Clinic into the world’s largest virtual clinic for women’s and family health.
Under her leadership, Maven has partnered with employers and health plans to deliver care across fertility, maternity, postpartum, paediatrics, and menopause at scale.
Her perspective sets the tone for a program centered on commercialisation, partnership, and sustainable growth.
Beyond the opening keynote, the newly released agenda reflects the sector’s growing maturity.
Across two days, the program features 70+ speakers, with representation from leading organizations including the FDA, Planned Parenthood, CVS Health Ventures, Samsung Next, NIH, WHO, and Maven Clinic.
Sessions span investment and deal flow, clinical innovation, regulation, data and technology, and market expansion, alongside dedicated pitch sessions and curated 1:1 matchmaking designed to turn insight into action.
The agenda has been built to facilitate meaningful connections across the ecosystem, with partnerships positioned as the primary driver of scale.
As women’s health continues to attract institutional capital and global attention, Women’s Health Week USA 2026 offers a clear snapshot of where the market is heading, and who is shaping it.
The full agenda is now live, with additional speakers and partners to be announced in the coming months.
View the full programme here.
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