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Menopause

MS does not worsen menopause symptoms, study finds

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Menopause is not linked to increased disability accumulation in women with multiple sclerosis, according to the largest study to date.

The study followed 987 Australian women with MS over 14 years, of whom 404 (40 per cent) had gone through menopause, and found no link between hormonal changes and disease progression.

Led by Monash University and published in JAMA Neurology, the research analysed data from the MSBase Registry, the world’s largest MS outcomes register, which tracks more than 120,000 people worldwide.

Associate Professor Vilija Jokubaitisis  deputy head of Monash University’s School of Translational Medicine Department of Neuroscience

The researcher said: “MS disability typically gets worse in both men and women as people age, with a noticeable shift at about the age of 50, which is also around the age of menopause for most women.

“During perimenopause, the amount of oestrogen and progesterone in women fluctuates a lot, before levels of these hormones fall significantly at menopause.

“In this study we asked whether the loss of sex hormones at menopause could be the reason for MS worsening in women at midlife.”

Participants were recruited from eight Australian neuroimmunology-specialist centres.

Earlier, smaller studies of between 74 and 148 post-menopausal women had produced mixed results about the role of sex hormones in MS progression.

The study found that while disability increases with age, menopause itself is not a direct cause, with other ageing processes likely responsible.

“Whilst reproductive ageing may be additive to the effects of somatic ageing, our study does not support menopause as the leading factor for disability progression in older women with MS,” the researchers concluded.

Dr Francesca Bridge, neurologist at Alfred Health and the study’s first author, said the findings should reassure women with MS.

“The menopausal transition can be challenging for many women,” Dr Bridge said.

“This study gives women with MS one less thing to be concerned about. This study will guide the health/clinical management of women with MS through the menopausal transition.”

She added that menopausal symptoms such as hot flushes, memory problems, mood changes and urinary dysfunction could overlap with MS symptoms.

“Women with MS will benefit from the holistic management of menopausal symptoms with lifestyle measures such as exercise and maintaining a healthy diet, as well as pharmacological measures such as menopausal hormone therapy (MHT) and non-hormone-based medications to improve their symptoms and quality of life,” she said.

The results are expected to shape clinical discussions about managing menopause in women with MS, including lifestyle adjustments and the use of hormone therapy where appropriate.

Menopause

Menopause care failing women worldwide, review finds

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Menopause care remains fragmented and unequal worldwide, leaving many women without evidence-based support, a major review has found.

The review identified significant gaps in care despite menopause affecting millions of people around the world.

Drawing on 89 studies from several countries and diverse populations, it found that many women experience fragmented services, limited access to evidence-based treatment and inadequate support from healthcare providers.

Women often reported feeling dismissed, unsupported and uninformed about menopause and the treatments available.

The review also found persistent inequalities in access to menopause support.

Race, socioeconomic status, cultural background and geography often shaped the barriers women faced when seeking care.

Researchers found that healthcare professionals often receive insufficient training on menopause.

National clinical guidelines were also applied inconsistently, while culturally responsive care remained limited.

These gaps were particularly evident among marginalised groups, including LGBTQ+ people, Indigenous communities, migrant women and those experiencing surgical menopause.

The review found that telehealth could improve access to menopause care, although the authors said it was not a universal solution.

They said its acceptability and suitability varied across different populations and settings.

The review called for better education and training for healthcare providers, clearer roles and responsibilities across health services and patient-centred, culturally competent models of care.

It also highlighted the need for a greater focus on equity to ensure everyone can access high-quality menopause support.

The findings were based on a review of 4,056 published records, with 89 studies meeting the inclusion criteria.

Most of the evidence came from the UK, US and Australia and included qualitative, quantitative, mixed-methods and intervention studies.

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Disadvantaged neighbourhoods linked to faster heart health decline in midlife women, research shows

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Women in disadvantaged areas may face poorer heart health and faster decline as they approach menopause, new research suggests.

Researchers followed 1,200 women in eastern Massachusetts for more than 20 years, from pregnancy into midlife.

The study measured heart health at five points using a score based on eight health and lifestyle factors, including blood pressure, cholesterol, sleep, diet and physical activity.

Women living in the most socially vulnerable neighbourhoods scored about six to 10 points lower on heart health across more than two decades of follow-up than those in the least disadvantaged neighbourhoods.

The differences were already clear three years after enrolment and continued into midlife.

Researchers also found that women in these neighbourhoods had faster declines before menopause, the stage when periods stop and cardiovascular risk can rise. Cardiovascular health means the health of the heart and blood vessels.

Socioeconomic factors also appeared to shape outcomes. Women with lower income, less education, or who identified as non-Hispanic Black had lower heart health scores throughout the study.

The findings highlight how long-term exposure to social and environmental conditions may affect cardiovascular risk over time.

Even modest differences in heart health scores may matter, as previous research has linked small decreases in these scores with higher risks of cardiovascular disease and death.

Senior author Izzuddin Aris, associate professor at Harvard Medical School and the Harvard Pilgrim Health Care Institute, said: “Our study shows that heart health in midlife is shaped by more than personal choices. Income, education, and neighbourhood conditions may all play a role.”

Neighbourhood conditions continued to affect heart health even after researchers took income and education into account.

Women who lived for years in highly vulnerable neighbourhoods had persistently lower scores and poorer cardiovascular health trajectories.

Aris added: “The years before and around menopause may be an important time to support women’s heart health.

“This is especially true for women living in under-resourced neighbourhoods.”

The findings suggest prevention efforts could include better access to healthy food, safe places to be active and quality healthcare, particularly for women seeking to protect their heart health over time.

The study used data from Project Viva, a long-term research study that has followed women since pregnancy in the early 2000s through midlife.

Researchers collected repeated health data over more than two decades, allowing them to track long-term patterns in heart health.

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Menopause

Many women still confused about perimenopause, research finds

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One in three US women older than 35 are no sure whether they are in perimenopause, new research has revealed.

The findings suggest uncertainty remains common, largely because of knowledge gaps, symptom confusion and difficulty getting confirmation or care.

Perimenopause is the transitional stage before a woman’s final period, when hormone levels fluctuate and symptoms can change over time.

It usually begins in the mid-40s, although timing varies widely, and can last for around four to eight years.

Symptoms can include hot flushes, psychological symptoms and urogenital symptoms, which affect the urinary and genital areas.

Dr Stephanie Faubion, medical director for The Menopause Society and one of the study authors, said: “This large study showed that one in three US women aged older than 35 years are not sure whether they are in perimenopause.

“Further, the study highlights that symptom confusion, misconceptions, and barriers to care are leaving many women without the clarity and support they need during the menopause transition.

“Recognising perimenopause uncertainty as a common experience can help shift the conversation from searching for a diagnosis to providing women with the information, validation, and support they need to navigate this natural life transition with confidence.”

More than 7,600 US women aged 35 and older took part in the study, which looked at how common uncertainty around perimenopause is and what may be driving it.

Overall, 34 per cent of participants said they were unsure of their reproductive stage.

Uncertainty varied by age and symptom burden, reaching 42 per cent among women aged 40 to 44 and 37 per cent among those with severe symptoms.

Symptom confusion was the most common factor, cited in 56 per cent of responses.

This included difficulty making sense of bodily changes and telling perimenopause apart from other possible causes, such as premenstrual syndrome, thyroid disease or mental health conditions.

Knowledge gaps and information-seeking made up 28 per cent of responses, reflecting limited awareness, age-based assumptions and attempts to find reliable information.

Barriers to confirmation and care made up 16 per cent, including dismissive healthcare encounters and reluctance to acknowledge perimenopause.

Younger women aged 35 to 39 were more likely to cite knowledge gaps, while healthcare barriers were most common among women aged 40 to 44.

The researchers said clinicians should take a more flexible approach to recognising the emotional, cognitive and physical symptoms that can occur during perimenopause.

They said healthcare professionals should not rely too heavily on irregular periods as the main sign, because some women have symptoms before major cycle changes.

 

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