Diagnosis
Study reveals a hidden risk after cervical cancer

Women who have survived cervical cancer face nearly double the risk of developing anal cancer later in life compared with the general population, new research shows.
The study analysed data from more than 85,000 women diagnosed with cervical cancer and followed them over two decades to track secondary diagnoses.
Researchers at MUSC Hollings Cancer Center found the risk increased with both age and time, with the highest rates among women aged 65 to 74 who were more than 15 years beyond their first diagnosis.
At present, anal screening is recommended for certain high-risk groups, including people living with HIV, organ transplant recipients and women with a history of vulvar cancer.
No clear guidelines exist for women who have survived cervical cancer.
Ashish Deshmukh is co-leader of the cancer prevention and control research programme.
The researcher said: “We’ve known for a long time that both cervical and anal cancers are caused by HPV, the human papillomavirus.
“But what hasn’t been well-understood is how that shared risk might connect the two diseases over a woman’s lifetime.”
HPV is a common virus that can lead to several cancers, including cervical and anal. Cervical screening and HPV vaccination have made cervical cancer largely preventable, with survival rates above 90 per cent when detected early, but guidelines do not address long-term risks for survivors.
The team used the National Cancer Institute’s SEER (Surveillance, Epidemiology and End Results) programme, which tracks cancer diagnoses across the US.
For women aged 65 to 74, rates of anal cancer diagnosis exceeded thresholds typically used to recommend routine screening.
Researcher Haluk Damgacioglu, PhD said: “Our study shows that the risk doesn’t go away – it actually increases with age and over time.”
This delay occurs because HPV-related cancers can take years or decades to develop.
The virus may remain dormant or spread from another part of the body.
Deshmukh said: “It’s a slow process, and that’s part of why it’s been so hard to detect. By the time symptoms show up, the cancer is often advanced.”
Screening methods do exist, including anal cytology (similar to a cervical smear test) and anoscopy (a visual examination using a scope), but access is limited.
In South Carolina, for example, there is only one provider trained to perform high-resolution anoscopy.
“Damgacioglu said: “These results tell us that women who had cervical cancer years ago should be considered for routine anal cancer screening.
“Right now, that’s not happening.”
Deshmukh and colleagues are expanding the work with a new project to evaluate the best screening approaches for this group, in collaboration with MD Anderson Cancer Center and the Icahn School of Medicine at Mount Sinai.
The study will look at frequency and methods of screening.
Features
Gender gap in treatment persists even when men and women have same condition

Women with the same medical conditions as men were less likely to receive the same treatment across several specialties, a global research review found.
The review found differences in care for conditions including cardiovascular disease, kidney disease and Parkinson’s, with women less likely to receive some active treatments.
Of 38 studies analysed, 33 found women were less likely than men to be offered active treatment.
Researchers at the University of St Andrews found women with myocardial infarction, heart failure or an irregular heartbeat were more likely to receive medication, while men were more likely to undergo coronary bypass surgery, stenting or other surgical treatment.
Women were also less likely to be prescribed statins.
Men with Parkinson’s were more likely to be referred for deep brain stimulation.
Men with liver failure were more likely to receive a transplant, while women with kidney disease requiring dialysis were less likely to receive permanent access and spent longer using a catheter.
Women were also less likely to receive opioids for pain management.
The researchers found no significant difference between women and men in treatment for stroke or diabetes, while women were more likely to receive treatment for dementia.
None of the studies identified clinical guidelines recommending different treatment based on sex.
Researchers said this suggested the differences could not be explained by the need for different clinical approaches to women’s health.
Dr Andrew O’Malley, who co-led the study, said: “For clinicians, the findings are a prompt to check whether treatment is being offered on clinical grounds rather than assumption.”
He said studies showed doctors more often attributed women’s symptoms to anxiety and made more diagnostic errors with female patients, even when test results were positive.
Dr Miriam Veenhuizen, honorary lecturer in the School of Medicine at St Andrews, said: “While the direction of the findings was not a surprise, the consistency was. The same pattern appeared in cardiology, surgery, transplant medicine and emergency care, and it survived statistical adjustment in most studies.”
Menopause
Menopause frequently missing from electronic health records – study

Menopause is often absent from women’s electronic health records, a study of nearly 396,000 women has found.
Researchers found menopause appeared almost seven times more often in participant surveys than in electronic health records (EHRs).
The findings suggest important reproductive health information, including age at menopause, may often be missing from health records used for research.
Audrey Hendricks, associate professor of bioinformatics at CU Anschutz and the study’s principal investigator, said: “Ultimately, we cannot study what we do not measure. We cannot treat what we do not know.
“Menopause has enormous implications for women’s health, but if we don’t consistently capture when menopause occurs and other important reproductive health information, we limit our ability to understand how this transition affects disease risk and health outcomes.”
Researchers at the University of Colorado Anschutz analysed data from women taking part in the National Institutes of Health’s All of Us Research Program.
They compared menopause information reported by participants in surveys with menopause diagnoses recorded in their electronic health records.
Around 193,000 menopause observations were identified in survey data, compared with approximately 28,000 diagnoses in EHR data.
Menopause was documented in electronic health records for only about 7 per cent of women in the dataset.
Nearly all participants with a menopause diagnosis recorded in their EHR also reported menopause in survey data. However, substantially fewer women had menopause documented in their health records.
Other important information was also frequently unavailable, including age at menopause, which researchers may use when examining links between menopause and chronic disease risk.
Menopause is a physiological transition that can affect cardiometabolic health and many other aspects of women’s health.
Researchers said relatively little is known about how factors including the timing and type of menopause influence health outcomes across diverse populations.
Large-scale programmes such as All of Us combine participant surveys, electronic health records and genomic data, but menopause-related research depends on relevant reproductive health information being available.
Missing menopause information can make it harder to investigate how the transition relates to health and disease.
The findings may also help researchers using All of Us data define menopause-related study populations, design studies and estimate how many participants are needed.
Hendricks said: “We have an enormous opportunity to use large-scale datasets to understand women’s health across the menopause transition and to identify who may be at greater risk for disease.
“But we need to make sure that the information researchers need is actually being collected.
“We must do a better job of capturing women’s health information, including reproductive health and measures related to menopause.”
Researchers said more complete and consistent collection of menopause and reproductive health information could help future studies examine factors such as age at menopause and their relationship with disease risk and health outcomes.
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