Access to vaccines and clinical trials for pregnant women vital in pandemics

The vast majority of women who contract bird flu during pregnancy and their unborn baby will die from the virus, according to a new study. The findings stress the importance of early inclusion of pregnant women in public health vaccination programs during pandemics.

The research recommends that as human cases of avian influenza viruses A (H5N1 and H5N2) increase, an awareness around the vulnerability of pregnant women to a new pandemic is urgently needed.

The systematic review of more than 1500 research papers examined 30 reported cases of bird flu in women who were pregnant across four countries.

The review found that women died in 90 per cent of cases when infected with bird flu during pregnancy with almost all their babies dying with them. Of the small number of babies who survived, 80 per cent were born prematurely.

Murdoch Children’s Research Institute (MCRI) Dr Rachael Purcell said the inclusion of pregnant women as early as possible in pandemic planning must be a key priority.

“Increasing numbers of human cases of avian influenza associated with outbreaks in birds and mammals raises concerns about the possibility of another pandemic in the near future,” she said.

“Despite being a high-risk population, pregnant women are often excluded from vaccine trials, priority access to therapeutics and delayed entry into public health vaccination programmes. A paradigm shift is required to routinely include pregnant women in pandemic preparedness programs to avoid preventable deaths.

“This could be achieved through utilising the capacity of existing surveillance systems such as the Global Vaccine Data Network or the Vaccine Safety Datalink, the planning of vaccine trials to include the complex needs of pregnancy, and the upscaling of adverse reaction detection systems to identify risks in pregnant women.”

MCRI Professor Jim Buttery said during pandemics vulnerable populations were often at high risk of severe disease and death.

“Pregnant women have experienced high death and critical illness rates during the influenza and SARS-CoV-2 pandemics and the Ebola epidemic,” he said.

Global efforts are needed to proactively recognise and mitigate this risk prior to the onset of a pandemic, rather than as a reactive process once a health crisis has started.

Buttery said: “Ethical pandemic preparedness to avoid preventable deaths requires early inclusion of vulnerable populations in vaccine development, monitoring and trials. A pregnancy focused research agenda should be developed and facilitated by medical review boards, regulators and policy makers.”