Wellness
Scientists develop mini-ovaries that could advance infertility research

Scientists have successfully created laboratory-grown human ovary models from stem cells, marking a potential breakthrough in infertility and reproductive disorder research.
The findings, presented at the Joint Congress of the European Society of Paediatric Endocrinology and the European Society of Endocrinology, offer new insights into female reproductive development.
The miniature organoids replicate key structural and functional features of ovarian follicles, which contain eggs and the cells that nurture them.
Researchers at the Institut Pasteur in Paris developed the models by differentiating human induced pluripotent stem cells into granulosa-like cells—essential for egg maturation—and primordial germ cell-like cells, then combining them to form human ovaroids.
While other ovaroid models exist, this is the first to combine these cell types without using exogenous transcription factors.
“Transcription factors are proteins that bind to specific DNA sequences and turn nearby genes on or off, so using external ones can override the innate genetic programme of the cells, which makes the derived populations unsuitable for disease modelling,” said senior author Dr Anu Bashamboo.
The models could improve understanding of differences in sex development (DSDs), conditions in which sex chromosomes and gonadal or anatomical sex do not align. Though rare (1 in 4,500 births), milder forms affect around 1 in 200 people.
During early human development, gonads begin forming at four weeks and develop into testes or ovaries by week six, making the process difficult to study.
Over the past 15 years, scientists have identified numerous genes involved in atypical gonad development, but around half of DSD cases due to gonad formation still lack a genetic diagnosis.
The same team previously generated Sertoli cells—testicular support cells commonly affected in DSDs—from human stem cells. They showed that Sertoli cells with male chromosomes (XY) and a genetic variant linked to atypical testis development could not form the 3D tubular structures of testis cords.
“By creating human-specific, lab-grown models of both testicular and ovarian development using induced pluripotent stem cells, the research overcomes key limitations in the field—particularly the lack of suitable animal models due to poor conservation of developmental genes and mechanisms across species—and provides a powerful platform for studying gene function in a controlled environment,” said Dr Bashamboo.
The new models offer a scalable system that could aid reproductive disorder research and lead to treatments for ovarian dysfunction and infertility.
“Our work more broadly contributes a scalable, human-relevant model system to developmental biology, reproductive medicine and genetic diagnostics. It bridges the gap between basic science and clinical application, offering tools that could improve diagnostic yields and support the development of targeted treatments for individuals with DSDs and related reproductive disorders, including infertility and certain types of ovarian tumours,” said Dr Bashamboo.
Dr Bashamboo added: “Our model also opens up new possibilities for screening drugs and environmental toxins affecting human gonads, personalised medicine and future therapeutic interventions.”
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News
Resistance training has preventative effects in menopause, study finds

Resistance training improves hip strength, balance and flexibility during menopause and may also improve lean body mass, research suggests.
A study of 72 active women aged 46 to 57 found those who completed a 12-week supervised programme saw greater gains than those who kept to their usual exercise routines.
None of the participants were taking hormone replacement therapy.
The supervised, low-impact resistance exercise programme focused on strength at the hip and shoulder, dynamic balance and flexibility.
Participants used Pvolve equipment, including resistance bands and weights around the hips, wrists and ankles, and also lifted dumbbells of varying loads.
Women in the resistance training group showed a 19 per cent increase in hip function and lower-body strength, a 21 per cent increase in full-body flexibility and a 10 per cent increase in dynamic balance, meaning the ability to stay stable while moving.
Those in the usual activity group did not show any significant improvements.
Previous studies have assessed the decline in lower limb strength and flexibility during menopause, but this is said to be the first study to compare the effect of resistance training on muscle strength and mass before, during and after menopause.
This was done by including participants in different phases of menopause rather than following the same participants over a long timeframe.
Francis Stephens, a researcher at the University of Exeter Medical School in the UK, said: “These results are important because women appear to be more susceptible to loss of leg strength as they age, particularly after menopause, which can lead to increased risk of falls and hip fractures.
“This is the first study to demonstrate that a low-impact bodyweight and resistance band exercise training programme with a focus on the lower limbs, can increase hip strength, balance, and flexibility.
“Importantly, these improvements were the same in peri- and post-menopausal females when compared to pre-menopausal females, suggesting that changes associated with menopause do not mitigate the benefits of exercise.”
Although one of the researchers sits on Pvolve’s clinical advisory board, the researchers said the company did not sponsor the study or influence its results.
Stephens added that any progressive resistance exercise training focused on lower-body strength is likely to yield the same results.
He said: “The important point is for an individual to find a type of exercise, modality, location, time of day etc., that is enjoyable, sustainable, and improves everyday life.
“The participants in the present study reported an improvement in ‘enjoyment of exercise,’ and some are still using the programme since the study finished.”
Kylie Larson, a women’s health and fitness coach and founder of Elemental Coaching, who was not involved in the study, said the results were compelling.
She said: “This is particularly exciting for those that tend to think of menopause as ‘the end’. The study proves that if you incorporate strength training you can still make improvements to your muscle mass and strength, which will also have a positive ripple effect to your ability to manage your body composition.
“In addition, staying flexible and being able to balance are both keys to a healthy and functional second half of life.”
Participants in the study did four classes a week for 30 minutes each session, but Larson said even half that amount of strength training can go a long way, particularly if you emphasise progressive overload, which means gradually increasing muscle challenge through more weight.
Larson said: “Gradually increasing the challenge is what drives real change.
“Lifting heavier over time is what builds strength, protects your bones, and keeps your body resilient through menopause and beyond.”
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