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Advanced 3D mammography detects more breast cancers and fewer false positives

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The newer, 3D form of breast screening, known as digital breast tomosynthesis (DBT), is more effective at detecting breast cancer than traditional 2D digital mammography (DM).

That’s the conclusion of an analysis of 13 years’ worth of screening data conducted by Yale Cancer Center researchers.

The data also suggests that 3D mammograms could reduce the incidence of advanced cancer diagnoses.

“Most of the time, women will do better with 3D mammograms since their cancers are being caught sooner,” said co-first author Dr Liane Philpotts, a professor of radiology and biomedical imaging at Yale School of Medicine (YSM) and a member of Yale Cancer Center.

The study results were published in Radiology, a journal of the Radiological Society of North America, on Sept. 17.

DBT reconstructs pictures of the breast taken from different angles into 3D images, whereas DM makes pictures of the breast from two angles.

YSM radiologists at Yale New Haven Health (YNHH) adopted the new DBT technology in 2011.

Researchers analysed 1,407 breast cancer cases detected from August 2008 to July 2021, including 35,544 DM screenings and 237,394 DBT screenings.

Researchers compared a range of data, such as patient demographics, imaging results, and pathology reports.

Results showed that DBT had a higher rate of cancer detection than DM (5.3 versus 4 per 1000 screenings) without leading to overdiagnosis of less harmful cancers that shouldn’t impact a patient’s life.

Also, the false positive recall rate (when a woman undergoes additional testing after a screening finds a non-cancerous abnormality in her breast) was significantly less for DBT at 7.2 per cent compared with 10.6 per cent for DM.

Philpotts says fewer false positives and the overall higher cancer detection rate is a win-win and shows DBT is not over-diagnosing cancers.

“Based on the results, DBT is an effective screening tool that not only finds more cancers, it catches them earlier at a lower stage, which means fewer advanced cancers,” said Philpotts.

“And over time, when women have repeated 3D mammograms, the number of advanced cancers diagnosed is even lower.”

A randomised clinical trial to assess the impact of DBT is ongoing.

Philpotts added that she would like to see other long-term studies that compare DBT and DM.

She hopes this retrospective study provides data useful to health care institutions still considering the new screening technology.

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AI innovation to be celebrated at Femtech World’s third-annual awards event

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Health tech companies advancing female health outcomes through AI innovation are being encouraged to enter Femtech World’s third-annual awards event.

The awards celebrate the best examples of leadership, innovation and impact in key areas that affect women’s health and wellbeing.

Introduced in 2025, the AI Innovation award honours an individual or organisation pioneering the use of artificial intelligence to transform women’s health.

The winner will have demonstrated groundbreaking innovation in applying AI to improve diagnosis, treatment accessibility, or overall health outcomes for women.

The award is sponsored by Women’s Health Week, whose flagship women’s health conferences across Europe and the USA unite the complete ecosystem.

This includes visionary founders, strategic investors, multinational corporations, and specialised service providers – accelerating life-changing solutions that address women’s most critical unmet health needs.

Femi Adetoro, marketing manager, Women’s Health Week, said: “We’re happy to be back partnering with the Femtech World Awards for another year as a part of our commitment to highlighting the innovators disrupting women’s heath with investable and scalable products/services.”

Molly Taylor, head of content, Women’s Health Week, added: “We’re especially excited to be sponsoring the AI Innovation category this year as it aligns strongly with our mission to spotlight innovation that’s driving health impact for women worldwide.”

The AI Innovation award is one of 10 featuring at the event, which last year attracted entries from across the UK, Europe and North America.

Award winners will receive a trophy and the opportunity to be interviewed by Femtech World.

Both winners and shortlisted entries will receive extensive coverage across all Femtech World platforms.

Find out more and enter for free here.

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Sunfish and Ivy Fertility expand partnership

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Fertility finance platform Sunfish has expanded its partnership with US clinic network Ivy Fertility to support patients across all 28 of its locations.

The deal will give all Ivy patients access to Sunfish’s Financial Hub, a platform designed to help people navigate the costs of medically assisted fertility care, as well as its loan marketplace and network of partner lenders.

Select clinics will also offer Sunfish’s IVF Success Program, which uses biodata to create customised flat-fee IVF bundles. IVF (in vitro fertilisation) involves fertilising an egg in a lab and transferring the embryo to the uterus.

Angela Rastegar, chief executive and co-founder of Sunfish, said: “Ivy was one of our first clinic partners, and three years and hundreds of patients later, we’re thrilled to support even more families on their fertility journeys.

“As someone who has been through the process myself, I have always believed that IVF shouldn’t feel like a financial gamble, and now at Sunfish, we’re using data, AI, and design to make care more accessible and easier to navigate.

“This combination of predictive analytics and financial protection, paired with the exceptional patient care Ivy offers, is transforming how families and clinics think about fertility and financing.”

Sunfish says its approach is proving effective.

According to the company, 70.8 per cent of embryo transfers among its patients have resulted in a successful pregnancy and graduation to an obstetrician, compared with a national average of 54.3 per cent.

The firm also says twice as many patients without insurance have been able to start treatment at clinics offering its programme.

For patients using Sunfish’s IVF Success Program, the company’s predictive model uses AI and biodata to estimate the total cost from first consultation through to delivery.

The firm offers a cost guarantee and partial refund if treatment is unsuccessful.

Constance Rapson, chief growth officer at Ivy Fertility, said: “As a long-time Sunfish partner, we’ve seen how they are using new technology to make the patient experience excellent by providing greater financial support and clarity, ultimately helping more people go home with a baby.

“We’re excited to bring this innovative care to all of our patients.”

Financial barriers remain a significant obstacle to fertility treatment in the US.

Data suggests 54-65 per cent of prospective patients drop out of treatment, often due to financial strain.

Sunfish also announced an expansion of its Sunfish Cares initiative to all of its clinic partners, which contributes at least US$1,000 towards every new IVF Success Program patient at participating clinics through to the end of the year.

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Femtech in 2025: A year of acceleration, and what data signals for 2026

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By Celine Vignal, co-founder of Seesaw Health

The past year marked a turning point in femtech.

After a decade of steady progress, 2025 delivered a wave of innovations that pushed women’s health technology into a more mature, data-driven, and clinically integrated era.

From AI-enhanced hormone analytics to nervous-system biofeedback, companies shifted away from generic wellness and moved toward precision, personalisation, and validated outcomes.

With women now representing more than 80 per cent of household healthcare decisions and nearly 50 per cent of the global workforce, the demand for tools that reflect biological realities and not just generalised averages, has never been stronger.

Major Developments in 2025: From Hormone Intelligence to Pelvic Care

One of the most notable advancements in 2025 was the rapid evolution of AI-powered fertility and hormone-tracking technologies.

Fertility platforms expanded beyond ovulation prediction to offer multi-hormone modeling, giving users clearer insights into perimenopause, thyroid interplay, and metabolic patterns.

The industry also saw a surge in devices capable of real-time hormone detection, supporting more personalised care for women across all life stages.

Menopause tech continued its expansion.

What began five years ago as symptom-logging apps has now grown into integrated care platforms offering telehealth, digital coaching, non-hormonal treatment plans, and AI-based flare-up predictions.

Companies are increasingly leveraging longitudinal data to help identify early markers for sleep disruptions, cardiovascular risk, and mood instability, issues that disproportionately affect midlife women yet have historically lacked attention.

Meanwhile, menstrual and pelvic-health technology advanced significantly.

In 2025, startups brought to market more precise ways to monitor menstrual patterns, pelvic floor function, and chronic conditions like endometriosis.

We saw a rise in devices that combine sensor technology with therapeutic guidance. This reflects a deeper shift: women’s health problems long dismissed as “normal” are now being re-examined through a scientific lens, supported by better data and better tools.

Maternal health also benefited from this momentum.

Remote monitoring platforms now help track blood pressure, glucose variability, and stress biomarkers throughout pregnancy and postpartum, improving early detection for conditions like preeclampsia and gestational diabetes.

Importantly, many of these solutions are being built with inclusivity in mind, aiming to reduce disparities that have persisted for decades.

The Role of Nervous-System Data in Personal Health

Throughout 2025, the value of autonomic data—the signals that reflect how the body responds to stress—gained recognition as a critical element of women’s health.

New biosensors and software have made it possible to measure parasympathetic activity in real time, offering a window into how the nervous system modulates inflammation, pain, hormonal stability, and emotional regulation.

This represents a major shift: instead of using stress-reduction apps that rely solely on self-report or generic protocols, people can now see how their body responds physiologically in the moment.

Beyond wellness applications, this kind of data has important potential for chronic conditions that affect women disproportionately.

Autonomic dysregulation plays a role in migraines, IBS, endometriosis, PCOS, anxiety disorders, and perimenopause symptoms.

Tools that help women understand and regulate their stress response could become a critical layer of preventive care.

Predictions for 2026: Relying on Body Data

1. Nervous-system biomarkers will become as common as heart-rate data

In 2026, real-time stress measures, such as vagal tone, respiratory patterns, and autonomic balance, will increasingly appear in wearables and therapeutic devices.

Seesaw Health is one example of this trend, offering sensor-driven insights into parasympathetic activity to personalise breathwork and recovery.

We’re also seeing early signals from devices integrating sensors directly into earbuds and ambient sensors that adapt lighting and sound based on autonomic patterns.

2. Pelvic and menstrual health will enter a precision-care era

Expect more clinical validation and early-detection tools.

Startups are already piloting AI-powered ultrasound analysis for early endometriosis suspicion and pelvic-floor trainers like Perifit that adjust programmes based on muscle response rather than user guesswork.

High-resolution menstrual-mapping platforms will expand beyond risk scoring to offer cycle-specific care recommendations.

3. AI-driven coaching will personalise daily health decisions

Virtual health assistants will combine biological data with contextual signals to offer just-in-time guidance like Maven Clinic.

Some tools are already experimenting with flare-up prediction for PMDD or endometriosis, and with workout-modification engines that adapt intensity based on inflammation, sleep debt, and stress load.

As these models mature, daily self-care routines could become far more adaptive.

4. Menopause platforms will formalise into mainstream care

With over one billion women projected to be in perimenopause or menopause by 2030, insurers and health systems are beginning to integrate menopause-specific care pathways.

Tools offering cognitive-support modules, cardiovascular risk tracking, and metabolic change monitoring will likely become standard, especially those like Elektra Health combining telemedicine care with evidence-based education.

5. The consumer–clinician bridge will narrow

Women increasingly expect their digital tools to generate data they can share with providers.

In 2026, more apps will automatically produce structured summaries for clinicians, covering pain patterns, autonomic signals, cycle changes like Mira Fertility, or medication effects.

Early pilots are underway exploring integration of pelvic sensor data into PT workflows and autonomic summaries into functional medicine assessments.

About the Author

Celine Vignal is the co-founder of Seesaw Health focused on female physiology, stress regulation, and preventive care.

Her work centers on translating complex nervous-system science into accessible tools and biofeedback parasympathetic breathwork methods that support everyday resilience and nervous system balance.   

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