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Start-up secures US$5.5m to tackle chronic pain

Women generally experience more recurrent pain, more severe pain and longer lasting pain than men

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The US medtech company JOGO Health has raised over US$5.5m to “transform” the treatment of chronic pain and neuromuscular disorders.

Chronic pain affects a higher proportion of women than men around the world. However, women are less likely to receive treatment.

Research shows women generally experience more recurrent pain, more severe pain and longer lasting pain than men.

JOGO’s wearable technology and app use the brain’s natural neuroplasticity to provide non-invasive, drug-free relief for conditions, including chronic lower back pain, stroke recovery, migraines and incontinence.

The investment round, led by Hourglass Ventures, is hoped to help JOGO expand and improve the treatment of chronic pain and neuromuscular disorders for millions worldwide.

“The conviction of our investors is phenomenal,” said Siva Nadarajah, president and co-founder. “This round will enable us to meet growing demand.”

The funding, Nadarajah said, would support JOGO’s commercial launch, putting JOGO on track to become the first line of treatment for chronic pain and other neuromuscular disorders, impacting one in five people globally.

Due to high demand, the co-founder said JOGO is opening the round to public retail investors via a Regulation CF community investment round on Wefunder, inviting retail investors to join alongside firms like Mayo Clinic Ventures, the venture arm of the world-renowned hospital.

The community investment round is open to everyone via Wefunder, with a minimum investment of US$100.

Sanjai Murali, co-founder and CEO, said: “We believe healthcare is too important to be controlled by a few. “JOGO is founded on the vision of ‘by the world, for the world,’ and opening our investment round to retail investors on Wefunder is a crucial step towards realising this vision.”

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Fertility & pregnancy

Xella Health announces Oura data integration

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Xella Health has integrated Oura wearable data into its women’s health platform, allowing members to share trends with clinicians alongside diagnostic results.

Members can choose to share information including sleep, heart rate variability, resting heart rate, temperature trends, recovery, activity and menstrual-cycle data.

The integration is intended to help clinicians investigate biological factors that may explain changes in members’ wearable data and symptoms.

Kelly Lacob, chief executive and co-founder of Xella Health, said: “Wearables detect that something in the body has changed, but wearable data alone can’t tell a woman why or what to do next with that information.”

“By pairing continuous physiological monitoring from Oura with Xella’s multiomic diagnostics and physician-guided care, we enable women to understand how specific health concerns are impacting her biometrics, and vice versa how her daily habits are impacting her overall health and specific conditions or life stages she is navigating.

“Further, we are able to track how her relevant vitals and biometrics respond to specific interventions or treatment plans, so we can optimise her care more efficiently.

“Ultimately, this partnership helps us better address her symptoms today whilst also proactively optimising her long-term health trajectory for decades to come.”

Xella Health combines AI, multiomic testing and physician-guided telehealth care through a membership platform.

Multiomic testing analyses several types of biological information.

Xella said its testing assesses hormonal and metabolic health, inflammation, nutritional status, reproductive health and cardiometabolic risk.

Physicians use those findings to develop personalised care plans that may include clinical treatments.

Clinicians can then review shared Oura trends alongside diagnostic results and member check-ins to monitor progress and adjust care over time.

The company said providers interpret biometric data in the context of each member’s health conditions, goals and treatment plan.

The integration focuses on fertility, perimenopause, hormonal and cardiometabolic health, as well as women’s longer-term health.

Oura has expanded its women’s health offerings through integrations connecting wearable measurements with other sources of health data.

In February, it partnered with at-home hormone tracking company Mira, allowing users to view hormone test results alongside sleep, temperature and readiness data in the Mira app.

The integration is intended to help users track patterns related to fertility, menstrual cycles and perimenopause.

That month, Oura also introduced a women’s health AI model for testing through Oura Labs.

Integrated into Oura Advisor, the model combines biometric data with clinician-reviewed medical information to provide guidance on menstrual cycles, pregnancy and menopause.

In May, the company launched menopause insights and hormonal birth control support.

Its Menopause Insights offering uses a questionnaire covering 22 symptoms of menopause alongside wearable data, while birth control support helps users understand their biometric trends in the context of hormonal contraception.

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Menopause

Tech enables men to experience what a hot flush feels like

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Partners of women going through menopause will be invited to experience hot flushes using a menopause simulator at a support event in Hull next month.

Health group Over The Bloody Moon will bring one of its MenoVests to the Menopaus’ull Support Network event, allowing people to experience a hot flush.

Sarah Weichardt, who co-manages the project, said: “We’re particularly interested in getting men along to come and experience the MenoVest, just so that they can understand what women go through.

“It’s not just a hot flush, it’s what the hot flush brings with it.

“So it could be panic, it could be anxiety. It’s experiencing it all at the same time.”

MenoVest is billed as the ‘world’s first’ wearable menopause simulator – a garment worn over regular clothing that generates realistic, intense hot flush sensations while the wearer carries on with everyday work tasks.

After just a few minutes wearing it, people gain a genuine sense of what these symptoms feel like, building empathy and highlighting why better support matters during this transition.

Weichardt said she hoped the vest would give people a “better understanding of what women are going through”.

“The more people we can get to experience it, the better,” she added.

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Menopause

Short term HRT may raise blood clot risk – study

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Short-term oral HRT was linked to a 60 per cent higher rate of serious blood clots in women aged 50 to 69, a large study found.

The increased rate was seen among women using oral hormone replacement therapy for less than a year as well as those treated for more than five years.

By contrast, transdermal HRT, delivered through skin patches, gels or sprays, was not associated with the same increased clot risk.

Researchers at North Zealand Hospital in Denmark analysed health registry data from more than one million Danish women aged 50 to 69 between 2003 and 2021.

During the study period, 9,807 women experienced venous thromboembolism, a serious blood clot in a vein. A further 18,460 had a stroke and 11,974 had a heart attack.

Each affected woman was matched by age with five women who had not experienced the same condition. Researchers adjusted the analysis for other factors, including medical history, that could influence risk.

They then examined HRT prescriptions, including the dose and duration of treatment, and looked for associations with blood clots, stroke and heart attack.

Overall, oral HRT was associated with a 60 per cent higher rate of venous thromboembolism, with increased rates seen for both oestrogen-only therapy and treatment combining oestrogen with progestogen.

Venous thromboembolism occurs when a blood clot forms in a vein. A clot in a deep vein can break away and travel to the lungs, causing a potentially fatal pulmonary embolism.

Women taking oral HRT for less than a year had the same raised blood clot risk as those using it for more than five years.

Even a daily oral dose below 1mg was found to significantly increase blood clot risk.

Women taking a daily oral dose above 1mg for more than five years had an 80 per cent higher risk of both heart attack and stroke.

For women taking a high oral dose for more than one year, the study found a 40 per cent higher risk of heart attack and a 50 per cent higher risk of stroke.

The researchers highlighted the importance of choosing the type, dose and duration of treatment carefully, particularly for patients vulnerable to blood clots.

Dr Robert Storey, professor of cardiology at the University of Sheffield, who was not involved in the research, said the findings demonstrated the importance of ensuring cardiovascular risk factors were “well controlled” in women taking oral HRT.

He added: “The study emphasises the superior safety of patches over oral treatment.”

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