Mental health
Stress linked to increased heart risk in women
Women with high psychosocial stress show early heart changes linked to cardiovascular disease, with no similar association in men, a recent study has found.
The findings support sex-specific effects of stress on cardiovascular health and suggest that risk assessment should include psychosocial factors and mental wellbeing.
Judy Luu is assistant professor at the Division of Clinical and Translational Research at McGill Faculty of Medicine.
She said: “From an epidemiological point of view, we have known for about two decades that stress is an important risk factor in cardiovascular health for people born female.
“But with this research stream, we’re really aiming to understand how stress physiologically impacts the heart.”
Cardiac MRI measures T1 and T2 in heart muscle, signals related to tissue composition and water; higher values can indicate early disease.
The study, conducted by researchers from McGill and Concordia universities in Canada, examined MRI heart scans of 219 adults aged 43 to 65, about half of whom were female.
The scans assessed T1 and T2 markers linked to early cardiac disease.
Participants were divided into two groups: those with at least one cardiovascular risk factor (such as diabetes, hypertension or smoking) but no heart disease, and healthy controls.
In both groups, women reporting high psychosocial stress had significantly higher T1 values than low-stress women.
T2 was also higher in the at-risk group only. No significant differences were seen between high- and low-stress men.
She added that the sex differences observed are not only a social question, but also a biological question.
Luu said: “Research points to the fact that there are biological differences in the way females physically handle stress.”
The next phase of the research will focus on blood markers and other biological explanations, such as hormones.
The team hopes the work can lead to better interventions to advance women’s heart health.
Ageing anxiety may accelerate biological ageing in women, with fears about worsening health linked to faster epigenetic ageing, according to new research.
The study found that greater anxiety about growing old was associated with accelerated epigenetic ageing, as measured by the DunedinPACE clock, based on biological markers in blood samples.
Epigenetic changes are shifts in how genes are switched on or off without altering DNA itself, which can influence how the body ages and functions.
“Our research suggests that subjective experiences may be driving objective measures of ageing,” said Mariana Rodrigues, a PhD student and the first author of the study.
“Ageing-related anxiety is not merely a psychological concern, but may leave a mark on the body with real health consequences.”
Researchers analysed data from 726 women in the Midlife in the US study.
Participants were asked how much they worried about becoming less attractive with age, having more health issues and being too old to have children.
Blood samples were used to assess ageing with two epigenetic clocks: DunedinPACE, which estimates the pace of biological ageing, and GrimAge2, which estimates cumulative biological damage.
The study was conducted by researchers at NYU School of Global Public Health.
Worrying about declining health showed the strongest links with epigenetic ageing, while anxiety about attractiveness and fertility was not significantly associated with biological markers.
The authors suggest health worries are more common and persist over time, whereas concerns about appearance and reproduction may fade with age.
“Women in midlife may also be multiple in roles, including caring for their ageing parents,” Rodrigues said.
“As they see older family members grow older and become sick, they may worry about whether the same thing will happen to them.”
The authors caution that the study offers a snapshot in time and other factors may influence these biological changes.
When analyses were adjusted for health behaviours such as smoking and alcohol use, the link between ageing anxiety and epigenetic ageing decreased and was no longer significant.
“Our research identifies ageing anxiety as a measurable and modifiable psychological determinant that seems to be shaping ageing biology,” said Adolfo Cuevas, associate professor of social and behavioural sciences and the study’s senior author.
They call for more research to clarify how this anxiety influences ageing over time, to guide support for those experiencing ageing anxiety.
“Ageing is a universal experience.” Rodrigues said.
“We need to start a discourse about how we as a society, through our norms, structural factors and interpersonal relationships, address the challenges of ageing.”
Mental health
Women with ADHD almost twice as likely to experience perimenopause symptoms, study finds
Women with ADHD are nearly twice as likely to experience perimenopause symptoms compared with women without ADHD, new research has revealed.
The study reported 54 per cent of women with attention deficit hyperactivity disorder had perimenopausal symptoms, compared with 30 per cent without the condition.
Among perimenopausal women with ADHD, 59 per cent reported psychological symptoms such as anxiety, low mood, irritability and fatigue.
Physical symptoms, including hot flushes, headaches or palpitations (a rapid or irregular heartbeat), occurred in 30 per cent with ADHD versus 14 per cent without.
Published in 2025, the research also found symptoms tended to start earlier for women with ADHD, peaking around ages 35 to 39, while those without ADHD reported their most severe symptoms around age 45.
The study suggests two explanations for the increased burden among women with ADHD.
Firstly, anxiety and lower socio-economic status are known risk factors for perimenopausal symptoms; both are more common among women with ADHD and chronic stress may amplify risk.
Secondly, oestrogen helps modulate ADHD symptoms.
Women with ADHD are at higher risk of premenstrual dysphoric disorder (PMDD) and other cycle-related issues because ADHD symptoms can intensify when oestrogen levels fall.
During perimenopause, oestrogen naturally declines, so women with ADHD may experience both typical perimenopausal symptoms and a worsening of ADHD symptoms at the same time.
The research also found a higher prevalence of lifetime post-traumatic stress disorder (PTSD) symptoms among women with ADHD.
When this factor was accounted for, women with ADHD who did not have PTSD still faced increased risks, though both risk and symptom intensity were reduced.
These findings suggest that interventions which reduce chronic stress and inflammatory responses could help women with ADHD navigate perimenopause more effectively.
Rapidly scaling startups often make rushed hiring choices that disadvantage women, a recent study has found.
The findings draw on more than 31,000 new ventures founded in Sweden between 2004 and 2018.
Researchers at the Stockholm School of Economics report that in male-led startups, scaling reduces the odds of hiring a woman by about 18 per cent, and the odds of appointing a woman to a managerial post by 22 per cent.
Mohamed Genedy is co-author and postdoctoral fellow at the House of Innovation, Stockholm School of Economics.
Genedy said: “During those moments of rapid growth, even well-intentioned leaders can fall back on familiar stereotypes when assessing who they believe is best suited for the role.”
The patterns emerge even in Sweden, regarded as a highly gender-equal national context.
Founders with human resources-related education counteract these challenges.
In ventures led by founders with HR training, the odds of hiring a woman increase by more than 30 per cent, and the odds of appointing a woman to a managerial role increase by 14 per cent for the same level of growth.
Genedy said: “When founders have experience with structured hiring practices, the gender gaps shrink, and in some cases even reverse.
“This shows that getting the basics of HR right early on really pays off.
“When things start moving fast, founders with HR knowledge are less likely to rely on biased instincts and more likely to hire from a broader talent pool.”
Prior experience in companies with established HR practices also helps, though to a lesser degree.
It raises the likelihood of hiring women as ventures scale, but does not significantly affect managerial appointments.
The study additionally shows these patterns are not driven by founder gender alone.
Even solo female-led ventures display similar tendencies when growing rapidly, though to a somewhat lesser degree.
In female-dominated industries, rapid growth increases the hiring of women for regular roles but still reduces the likelihood that women are appointed to managerial positions.
“When scaling accelerates, cognitive bias kicks in for everyone. Female founders are not immune to these patterns,” said Genedy.
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