News
Women with HR-positive breast cancer could use IVF without increased risk of recurrence- study
A new study examined pregnancy and cancer outcomes among patients who paused endocrine therapy to conceive

Using fertility preservation and assisted reproductive technologies such as IVF did not impact cancer recurrence rates among women with HR-positive breast cancer, a new study has shown.
Fertility preservation refers to methods intended to maintain the reproductive potential of the patient.
Such methods include ovarian stimulation for egg freezing, cryopreservation of ovarian tissue and the use of gonadotropin-releasing hormone analogs during chemotherapy to reduce the risk of premature ovarian failure.
Assisted reproductive technologies include various techniques to help the patient become pregnant, such as the transfer of cryopreserved embryos into a patient’s uterus, ovarian stimulation for IVF, intrauterine insemination, embryo or egg donation, ovarian tissue transplantation and clomiphene use.
“With the increasing age of childbearing, it is becoming more likely that women will be diagnosed with breast cancer before starting or completing their families,” said Dr Hatem A. Azim Jr, an adjunct professor at the School of Medicine and Breast Cancer Center at the Tecnológico de Monterrey in Mexico.
“Many breast cancer patients may opt for fertility preservation prior to starting cancer treatment and/or may use assisted reproductive technologies to increase their chances of pregnancy.”
Results from the POSITIVE trial presented at last year’s San Antonio Breast Cancer Symposium suggested that patients with HR-positive breast cancer could safely pause endocrine therapy for up to two years to become pregnant without increasing their risk of breast cancer recurrence.
However, the safety of conceiving after fertility preservation and/or assisted reproductive technologies for these patients remains unclear.
“There is a concern within the medical community that the use of fertility preservation or assisted reproductive technologies methods, particularly those that entail the use of hormones, could have detrimental effects on patients with HR-positive breast cancers,” Dr Azim noted.
To understand the impact of fertility preservation and assisted reproductive technologies, Azim and his colleagues conducted an analysis of outcomes from the POSITIVE trial.
Among the 497 evaluable participants who paused endocrine therapy to attempt pregnancy, 368 (74 per cent) became pregnant.
Among the patients who underwent some form of fertility preservation, 179 used embryo or oocyte cryopreservation prior to enrolment in the POSITIVE trial, while 215 used some form of assisted reproductive technology to attempt pregnancy. The most commonly used assisted reproductive technology was ovarian stimulation for IVF and cryopreserved embryo transfer.
The study found that younger age and cryopreserved embryo transfer were the factors most associated with higher chances of pregnancy, with 82.4 per cent of patients who underwent cryopreserved embryo transfer becoming pregnant.
Ovarian stimulation for cryopreservation, which precedes cryopreserved embryo transfer, was not associated with worse disease outcomes.
“Participants who underwent cryopreserved embryo transfer during the study had higher pregnancy rates with no apparent short-term detrimental impact on breast cancer outcome,” Azim explained.
Additional analyses found that menstrual cycles returned within six months of pausing endocrine therapy in most patients who had amenorrhea at trial entry and the type of adjuvant endocrine therapy the patient had received had no impact on the time to pregnancy.
Furthermore, the researchers found that younger patients became pregnant in a shorter time.
“We found that at two years after enrolment, 80 per cent of women younger than 35 years had a pregnancy compared to 50 per cent of those who were older than 40,” Azim said.
“Our data demonstrate the efficacy and short-term safety of different fertility preservation and assisted reproductive technology options, building on the primary results of the POSITIVE trial and providing vital information for fertility counselling of young breast cancer patients.”
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Pregnancy
Pregnant women may reduce key health risk through more light exercise, study finds

Light exercise and less sitting may reduce pregnant women’s risk of serious blood pressure complications, according to a new study.
Researchers have proposed a daily activity and sleep guide that they say was linked to a nearly 30 per cent lower risk of hypertensive disorders of pregnancy.
The suggested pattern includes fewer than eight hours of sedentary time, at least seven hours of light physical activity, around 22 minutes of more intense activity and nearly nine hours of sleep.
The University of Iowa-led study examined the daily behaviours of 470 pregnant women across all stages of pregnancy.
Participants wore monitors that measured physical activity over 24-hour periods and recorded how long they spent asleep.
Hypertensive disorders of pregnancy include chronic high blood pressure, gestational hypertension and pre-eclampsia.
Gestational hypertension is high blood pressure that develops during pregnancy, while pre-eclampsia is a potentially serious condition involving high blood pressure and signs that organs may be affected.
Sedentary behaviour means being mostly inactive, such as sitting or lying down.
Light physical activity can include casual walking, moving around the home or standing.
Moderate to vigorous activity includes movement such as brisk walking, where breathing and heart rate increase.
Kara Whitaker, associate professor in the department of health, sport, and human physiology at Iowa and corresponding author of the study, said: “We are identifying the optimal composition of movement behaviours across the day associated with the lowest risk of developing HDP and the most improved health outcomes.
“This blueprint holds for each and every trimester of pregnancy.”
Study participants were enrolled at sites in Iowa City, Pittsburgh and Morgantown, West Virginia.
The women wore activity and sleep monitors for at least one week during each trimester of pregnancy.
Four in five participants were non-Hispanic white and nearly a quarter lived in rural areas.
The data showed a steep rise in risk among pregnant women who were sedentary for more than 10 hours a day.
Women who increased light physical activity to at least four hours a day reduced their risk of hypertensive disorders of pregnancy to 15 per cent from 30 per cent.
Whitaker said: “Just moving around more seems to have significant health benefits.
“And I think it also may be a more feasible target for women who are pregnant who are not exercising regularly.”
The researchers said they were surprised that longer durations of moderate to vigorous physical activity did not appear to provide additional benefit.
Sleep beyond a certain duration also did not appear to bring major further benefits.
Whitaker said: “Through this study, we are providing evidence that reducing sedentary behaviour and engaging in light physical activity are important, and maybe more important, when it comes to pregnancy and health.”
The findings may be relevant beyond pregnancy because clinical research has shown that women who develop hypertensive disorders of pregnancy are more than twice as likely to develop heart disease later in life.
Cardiovascular disease includes conditions affecting the heart and blood vessels, such as heart disease and stroke.
Whitaker said: “We know that cardiovascular disease is the number one killer of women, and if we can intervene in pregnancy and prevent women from developing a hypertensive disorder of pregnancy, we are putting them on a better trajectory, away from cardiovascular disease and toward more optimal cardiovascular health.”
The study was published online on June 10.
A second study, published online on May 27, looked more closely at the ratio and type of sedentary behaviour and light physical activity linked to a lower risk of hypertensive disorders of pregnancy.
Whitaker is a lead co-author on that study.
Co-authors in the June 10 study include Alex Crisp, Jaemyung Kim, Karina Smith, Donna Santillan, Mark Santillan and Bridget Zimmerman, from Iowa; Jacob Gallagher, from Iowa State University; Melissa Jones, from Oakland University in Michigan; Bethany Barone Gibbs, Katrina Wilhite, Alexis Thrower and Iqra Sheikh, from West Virginia University; and Sabera Rahman, Janet Catov, Christopher Kline and Maisa Feghali, from the University of Pittsburgh.
The National Institutes of Health, the University of Iowa Institute for Clinical and Translational Science, the University of Pittsburgh Clinical and Translational Science Institute and the West Virginia Clinical and Translational Science Institute funded the research.
News
Femtech World Awards 2026: Winners revealed

We are excited to reveal the winners of the third annual Femtech World Awards.
The winners were announced at a virtual event this afternoon attended by shortlisted companies, along with sponsors and judges.
The event welcomed guests from the UK, Europe, Asia, Africa and North America.
Thank you to all 174 entries, as well as the sponsors for making the event possible.
See you in 2027!
Femtech World Awards 2026 Winners

Winner:
Shortlisted:
IVI RMA x Juno Genetics
Natural Cycles

Winner:
Highly commended:
U-Ploid
Shortlisted:
Hello Inside

Winner:
WISE HF, led by Prof. Mary Ryder
Highly commended:
Cardiac College for Women
Shortlisted:
Hyvelle Ferguson-Davis
CognitiveCare

Winner:
Highly commended:
Youterus
Shortlisted:
ŌURA

Winner:
Shortlisted:
LeanShield by ParrotPal Group
Perigen

Winner:
Shortlisted:
Body Moody
Looop

Winner:
Shortlisted:
Owning Your Menopause
Womeno

Winner:
Shortlisted:
The Blue Box
Celbrea

Winner:
Shortlisted:
HealCycle
Mor

Winner:
Shortlisted:
HRC Fertility
Mira
Motherhood
Expectations about sleep affect postpartum sleep quality, study finds

Pregnant women’s expectations about postpartum sleep may predict sleep quality after birth, outweighing prior sleep and psychiatric history, a study suggests.
The findings suggest attitudes and beliefs about sleep during pregnancy could be a modifiable risk factor for postpartum sleep concerns.
They also indicate that, among women expecting the poorest sleep, higher postpartum anxiety may further worsen sleep quality.
Sammy Dhaliwal, lead author is clinical health psychologist and research fellow in the department of obstetrics and gynaecology at the Perelman School of Medicine at the University of Pennsylvania.
Dhaliwal said: “Most pregnant women in our sample anticipated poor postpartum sleep before it occurred, and it was striking that those expectations predicted worse sleep outcomes even after accounting for factors such as prior sleep disorders, psychiatric history, and number of previous births.
“This suggests that attitudes and beliefs about sleep during pregnancy may represent a modifiable target for early intervention before postpartum sleep problems emerge.”
Sleep disturbance affects an estimated 60 to 80 per cent of postpartum women and is linked to a higher risk of depression and anxiety.
Researchers said it is often regarded as an expected part of life after childbirth rather than a health issue that may be addressed earlier.
The study enrolled 432 pregnant women at about 24 weeks of gestation, meaning around 24 weeks into pregnancy.
Participants completed measures of their expectations about postpartum sleep, current sleep quality using the Pittsburgh Sleep Quality Index, and mood using validated depression and anxiety scales.
Assessments were repeated at six, 12 and 24 weeks postpartum.
A subset of 49 women also wore wrist actigraphy devices at six to eight weeks postpartum.
Actigraphy uses a wearable device, similar to a watch, to estimate sleep and wake patterns based on movement.
The results showed that 70 per cent of pregnant women, or 301 of 432 participants, expected poor sleep in the postpartum period.
Researchers found that predicted sleep disruption during pregnancy was a significant predictor of postpartum sleep concerns.
Among first-time pregnant women without prior health concerns, those who expected greater sleep disturbance had significantly more disrupted sleep after birth, measured by both actigraphy and self-report.
Among women who expected the worst sleep quality, higher postpartum anxiety significantly worsened both measured sleep and self-reported sleep, independent of anxiety levels during pregnancy.
Dhaliwal said the findings point to two possible areas for intervention: addressing sleep-related beliefs during pregnancy and treating postpartum anxiety.
Dhaliwal said: “Postpartum sleep disruption is often treated only after problems develop, but our findings suggest there may be an opportunity to intervene earlier during pregnancy.
“Addressing sleep-related beliefs and postpartum anxiety during prenatal and postpartum care may help improve sleep and emotional well-being in new mothers.”
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