News
VC firm announces first close of women’s health fund
The investment covers sectors, such as medical devices, diagnostics, digital health, therapeutics and services
The venture capital firm KIDRON Capital Assets has announced the successful first close of its fund dedicated to women’s health.
Led by two female general partners with investment and industry expertise in the health tech sector, KIDRON aims to generate returns for its investors by capitalising on the extensive, yet often overlooked, opportunities within women’s health.
The firm seeks to support health tech companies that “leverage” patients data analytics to enable predictive, preventive and precision healthcare with emphasis on the most pressing unmet medical needs in women’s health.
We are pleased to announce the first close of Kidron Capital, the first women’s health-focused VC fund with a presence in Israel,”
“The fund will invest in early-stage companies that focus on improving the lives of women across the spectrum of conditions, from those unique to women to those that are predominant or different in women.”
The investment reach, according to , extends across Europe, the US and Israel, covering sectors, such as medical devices, diagnostics, digital health, therapeutics and services.
KIDRON has already made inaugural investments in several US-based companies, including Beyond Medicine, a start-up working towards improving skin rejuvenation and alleviating menopausal symptoms, Portal, a solution for oncology clinics and Renal Guard, a system designed to prevent acute kidney injury (AKI).
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Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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