News
UK women question government plans for women’s health strategy
Women’s charity found a quarter of women surveyed cited development of a women’s health strategy as their top concern
A quarter of women in the UK are questioning the government’s plans for a women’s health strategy, a new survey has found days before the general election.
The survey, conducted by the women’s charity Soroptimist International Great Britain & Ireland (SIGBI), has revealed the key topics women felt are most important for MPs to address ahead of the UK’s general election on Thursday.
Of the 482 women surveyed, all SIGBI members, 85 per cent felt one of the most pressing issue is funding domestic abuse services for women and children.
According to ONS data, more than one million women in the UK experienced domestic abuse in the year ending March 2023.
The other areas Soroptimists placed in their top three topics for government attention were how the government would develop a women’s health strategy (65 per cent), how the government would ensure the efforts of volunteers, charities, and civic society are valued and maintained (43 per cent) and how the government would bring more girls in the tech sector (41 per cent).
A quarter of respondents cited the development of a women’s health strategy as their top concern.
“While women make up 51 per cent of the UK electorate, they only make up 35 per cent of members of the House of Commons,” said Ruth Healey, president of SIGBI.
“There is nowhere near enough parliamentary representation, and this needs to change. Having more females in government is crucial, as this helps to ensure that legislation and policies are inclusive of women and girls’ needs and concerns.
“And in order to secure women’s votes, politicians will need to clearly communicate how they aim to address the challenges facing the 51 per cent, and how the lives of women and girls are at the heart of their policies.”
In 2022, the BMA reported that the UK has the widest gender health gap in the G20. And while women make up 50 per cent of the UK workforce, only 24 per cent of tech roles are occupied by women.
“Domestic abuse services, women’s health strategy development, and involving more girls in tech are all women-specific issues needing more focus and funding from the government,” said Ruth.
“The catalogue of stark statistics and our survey results combined clearly show more attention is needed in these areas and that women across the country want, and deserve, answers from MPs.”
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Cancer
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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