News
UK university experts to partner on reproductive health research
The initiative will be covering all aspects of the reproductive lifecourse, including menopause, contraception, infertility and urogynaecology
A group of UK university experts will collaborate on researching policy and patient experience for reproductive health provision, as part of a new Policy Research Unit (PRU).
The National Institute for Health and Care Research (NIHR) has awarded over £100m in funding to 20 new PRUs across England.
An estimated £20m of this funding has been given to PRUs being hosted by University College London, one of which will focus on reproductive health.
Covering all aspects of the reproductive lifecourse, including menopause, contraception, infertility and urogynaecology, the PRU will be a collaboration between the Universities of Birmingham, Oxford and Warwick, the London School of Hygiene and Tropical Medicine and Hywel Dda University Health Board.
“This much welcomed funding, going to a range of important health care issues, has rightly prioritised reproductive health,” said professor Dame Lesley Regan, women’s health ambassador for England.
“This is an important step in our mission to deliver the Women’s Health Strategy and emphasises the vital role that research plays in our understanding of the key issues that will determine how we improve women’s health and wellbeing.”
Dr Louise Jackson, associate professor at the Institute of Applied Health Research at the University of Birmingham, will be providing health economics expertise, reflecting her experience in evaluating interventions across a wide range of reproductive health and women’s health, including integrated health services, referral pathways and remote consultations for sexual and reproductive health.
She will also be co-leading the Models of Care theme, which will involve exploring and evaluating different ways of providing care for reproductive health, including through digital technology.
She commented: “The Institute of Applied Health Research has a reputation for impactful research in reproductive health and women’s health, both within the UK and globally.
“I am looking forward to working as part of the PRU’s multidisciplinary team to ensure government and arm’s length bodies have the best possible information and economic evidence available when making policy decisions about reproductive health.”
Fiona de Londras, professor of global legal studies at Birmingham Law School – who will be providing reproductive rights expertise across the PRU’s research, – added: “I am very pleased to bring this expertise to the PRU, and to ensure the full integration of human rights in the economic, evaluative, clinical, and participatory work that this vital investment in reproductive health will undertake.”
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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