Menopause
TaraCares is changing the conversation around female health “with swift execution”

Velocity of execution and acceleration of impact characterise this UK female-founded healthtech start-up.
From building a better working world as former director at EY running their people experience technology innovation business for more than 100 countries across Europe, the Middle East, India and Africa to building a healthier world with her new venture, “swift execution with measured strides” is how Jyoti Sharma likes to describe how the TaraCares team is changing the conversation around female health.
With social media spewing science vs influencer currency of menopause and debates on femtech vs healthtech, TaraCares chooses to be heads down on the evidence-base and the business case for impact at scale.
Within three months of incorporation Innovate UK, UK’s Innovation agency, awarded them a highly coveted and competitive R&D Grant award in September 2022.
2023 has also proved promising for the start-up, with the award of a second R&D Grant Award from a prestigious healthcare research body in the UK in February which will be formally announced at a later date.
The company has also been shortlisted in the top five start-ups in the Young Leader of the Year category at the HealthTech World 2023 awards.
In a market where founders are struggling to raise funds, Sharma is navigating alternative funding routes successfully equipped with 22 years of experience as an entrepreneur working with tech and management consulting giants such as SAP, Microsoft and EY.
Now, her team is in discussions with life science companies, healthcare providers and social care communities for the adoption of their female precision health platform to be launched later in 2023.
Crossing the borders to international trade, the company has been named as a Promising StartUp after a merit-based evaluation of 1,300 start-up applications and has been invited to the EU-StartUps summit taking place in Barcelona in April.
“We decided to give this opportunity as a reward to our hardworking product design team who will be representing the company at the summit,” said founder and CEO, Jyoti Sharma.
Additionally, the team is involving GenZs in their research by raising awareness and collaborating with the School for Business and Society at University of York. The case study of the joint work is aimed to be published later this year.
To learn more, visit taracares.co.uk or email femalehealth@taracares.co.uk.

Menopause
More research needed to understand link between brain fog and menopause, expert says

Brain fog in menopause is common but still poorly understood, with researchers calling for more work to explain the link and how best to support women.
For a new perspective article published in The Lancet Obstetrics, Gynaecology, & Women’s Health, researchers based in the UK and Australia reviewed the evidence on menopause-related cognitive symptoms. They found that symptoms such as forgetfulness, reduced concentration and brain fog are common during the menopause transition, but are still poorly recognised and under-researched.
More than two-thirds of women report difficulties with memory or concentration over the menopause transition. Multiple factors may contribute to these cognitive symptoms, including hormonal changes, sleep disturbances and psychological and psychosocial stress. Yet, because cognitive symptoms are not widely discussed, they can cause considerable worry, with some fearing they are signs of dementia or undiagnosed neurodevelopmental conditions.
The review paper emphasises that overall cognitive performance for women experiencing menopause-related brain fog typically remains within expected ranges and, importantly, that cognitive symptoms are not linked to an increased risk of dementia.
Professor Aimee Spector of UCL Division of Psychology and Language Sciences, co-author on the paper, said: “Cognitive symptoms such as forgetfulness and ‘brain fog’ are incredibly common during menopause, yet they are often overlooked. Our findings highlight just how complex menopause-related cognitive symptoms are, and how much we still don’t know about what drives them. More targeted research is essential if we are to identify which biological, psychological or lifestyle factors contribute most, and what types of support or treatment are likely to be effective.”
The authors argue that clinicians can play a key role in understanding and validating women’s experiences by asking about the duration of cognitive symptoms, impacts on day-to-day functioning and any other medical or psychosocial factors that could be contributing to cognitive symptoms.
The review also discusses a range of approaches that may ease cognitive symptoms, such as improving sleep quality, engaging in regular aerobic exercise and eating a balanced diet. There is also little but promising research into the impact of psychological therapies targeting cognitive symptoms, with a recent meta-analysis of three cognitive behavioural therapy-based studies showing significant improvements in memory and concentration. The evidence is more mixed for the benefits of hormone therapy on cognitive symptoms during menopause.
The authors identify cognitive symptoms as a major area of unmet need in menopause research. They call for a unified definition of menopause-related cognitive changes and for prospective, longitudinal studies that can track women from pre- to post-menopause. Better understanding of the biological, psychological and social factors that contribute to cognitive symptoms will be crucial for developing effective treatments.
Lead researcher Dr Caroline Gurvich of Monash University said: “There’s a lot of pressure to use objective measures of cognitive decline, like a memory test, for example, in a clinical trial, but the key symptom of brain fog is a subjective experience. So having a definition that acknowledges the key cognitive symptom is critical.”
This is not without precedent – we already use subjective or self-report measures for depression, anxiety and other mental health conditions with great success.
Dr Gurvich said the proposed definition would also validate women’s individual experiences while empowering them through the reassurance that any objective decline in their cognitive ability is subtle.
She added: “This is a decrease in cognitive or learning efficiency, not functionality or capacity. For many women, the perception they are losing capacity is what drives them to stop work or lose the confidence to live fulfilling lives during and after menopause. I hear all the time from women who have gone through menopause that validation would have made a significant difference to their resilience and the approach they took to living with menopause.”
Co-author Professor Martha Hickey of the University of Melbourne and Royal Women’s Hospital said: “Our analysis of the best available research shows that many women experience some degree of cognitive symptoms, such as brain fog, during the menopause transition.”
“But there’s a lack of long-term data, which means that there’s a gap in our knowledge about how the brain fog symptom develops and changes from peri-menopause to after menopause ends. It’s a real gap in our understanding.”
Professor Spector added: “We increasingly see women, typically at the peak of their careers, losing confidence in the workplace, often translating to leaving work or reducing work hours. Having simple strategies to support and retain them at work is also a broader economic issue.”
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