News
TaraCares awarded Research and Innovation Fast Start Grant to develop menopause precision medicine platform
The company works with women who participate on a volunteer basis to share their lived experience of menopause
The health tech start-up TaraCares has been awarded the highly competitive Fast Start Award by UKRI Innovate UK to progress research and innovation activities to develop an evidence-led, decentralised precision medicine platform tackling misinformation, misdiagnosis and mismanagement of menopause.
Thanks to Innovate UK, UK’s innovation agency which recognised the criticality of women’s health equity, TaraCares has been able to team up with a carefully selected set of experienced scientists, researchers, engineers, technologists, nutritionists and entrepreneurs who value science and robust research to inform women’s health.
The company works with women who participate on a volunteer basis to share their lived experience of menopause to help other women.
Research partnerships with leading universities is central to its execution strategy, as academia represents an important sector that needs to step up its efforts for mobilising support for staff in menopause transition.
The team behind TaraCares are proud to be collaborating with one such organisation that has stepped up – Sheffield Hallam University with Dr Sally Jackson, chief people officer and pro vice-chancellor (diversity and inclusion) at Hallam.

Funding from Innovate UK has propelled the company’s research into exploring Artificial Intelligence (AI) and machine learning capabilities for its digital health solutions, establishing AI in healthcare research collaboration with the University of Huddersfield.
Reflecting on the partnership, Dr Tianhua Chen, PhD senior lecturer in AI at the School of Computer Science and Engineering, University of Huddersfield, said: “It’s been very pleasant working with Jyoti [TaraCares founder] who I see is a very passionate, determined and Jill-of-all-trades entrepreneur striving to use clinical excellence and cutting-edge AI technologies to promote the understanding of menopause, which is an unmet global need in its awareness, diagnosis and management.”

TaraCares is committed to every single female across the globe to deliver precision medicine for menopause care irrespective of your socio-economic background, health status and type of menopause transition – natural, early, surgical, premature ovarian insufficiency (POI).
The team are breaking new ground and pioneering research in questions that have never been asked because society and governments have not been intentional about female health.
The start-up aims to spearhead a new paradigm of equitable female health where menopause and associated secondary health conditions, cardiovascular disorders, osteoporosis, anxiety and depression among others receive the individualised care that is warranted for long term female health.
If you are a female reading this, you can participate in TaraCares’ ongoing research.
By participating in the study you will be part of a global movement for delivering evidence-based, individualised and integrated menopause care that is accessible and affordable.

To learn more, visit taracares.co.uk or email femalehealth@taracares.co.uk.

Cancer
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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