News
Start-up secures US$5.5m to tackle chronic pain
Women generally experience more recurrent pain, more severe pain and longer lasting pain than men
The US medtech company JOGO Health has raised over US$5.5m to “transform” the treatment of chronic pain and neuromuscular disorders.
Chronic pain affects a higher proportion of women than men around the world. However, women are less likely to receive treatment.
Research shows women generally experience more recurrent pain, more severe pain and longer lasting pain than men.
JOGO’s wearable technology and app use the brain’s natural neuroplasticity to provide non-invasive, drug-free relief for conditions, including chronic lower back pain, stroke recovery, migraines and incontinence.
The investment round, led by Hourglass Ventures, is hoped to help JOGO expand and improve the treatment of chronic pain and neuromuscular disorders for millions worldwide.
“The conviction of our investors is phenomenal,” said Siva Nadarajah, president and co-founder. “This round will enable us to meet growing demand.”
The funding, Nadarajah said, would support JOGO’s commercial launch, putting JOGO on track to become the first line of treatment for chronic pain and other neuromuscular disorders, impacting one in five people globally.
Due to high demand, the co-founder said JOGO is opening the round to public retail investors via a Regulation CF community investment round on Wefunder, inviting retail investors to join alongside firms like Mayo Clinic Ventures, the venture arm of the world-renowned hospital.
The community investment round is open to everyone via Wefunder, with a minimum investment of US$100.
Sanjai Murali, co-founder and CEO, said: “We believe healthcare is too important to be controlled by a few. “JOGO is founded on the vision of ‘by the world, for the world,’ and opening our investment round to retail investors on Wefunder is a crucial step towards realising this vision.”
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Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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