Connect with us

Pregnancy

Meet the California start-up reimagining prenatal screening

Biotech start-up Juno Diagnostics is poised to support women through every step of the pregnancy journey

Published

on

Juno Diagnostics co-founder and chief medical officer, Dr Mathias Ehrich, and director of genetic counselling, Katie Sagaser

Born out of a need to address the problems within the US prenatal healthcare system, Juno Diagnostics is on a mission to shake up the landscape of traditional prenatal care. We speak to co-founder and chief medical officer, Dr Mathias Ehrich, and director of genetic counselling, Katie Sagaser, to find out more.

Tell us a bit more about the story behind Juno.

Mathias Ehrich: Our aim has always been to create equitable access to high-quality prenatal care. We want all women to have the opportunity to learn about their pregnancy and feel empowered to make informed decisions.

In launching the world’s first capillary-based cfDNA non-invasive prenatal screening test, we looked to create an affordable test that met our goals of accessibility and transparency.

So in 2011, the Juno co-founders and I were working together at a life sciences company to pioneer the development and commercialisation of the first cell-free DNA-based non-invasive prenatal screen (NIPS) in the United States.

There, we drove a lot of innovation in pregnancy care and prenatal care up until the company was acquired in 2016. At the time, only about 800,000 women had true access to NIPS.

So when we looked at the problem again, we found a couple of things in the market that were not working. 

First of all, most NIPS tests were too expensive, and second of all, they were difficult to access. In almost 50 percent of all US counties, women don’t even have access to an OB/GYN, let alone a phlebotomy service.

So women really had a problem with getting access to NIPS technology.

That’s when we realised that we needed to develop something that we could send in the mail and that could be shipped in a box, in a cheaper and a lot more accessible way. We needed to meet women where they are.

Katie Sagaser: From my experience as a genetic counsellor, I was able to see the ways in which a new type of test is introduced, especially in the genetic testing world.

There’s a lot of ‘healthy fear’ at first, but sometimes that ends up paralysing patients in a way that if we, as folks in industry, don’t equip them with the right resources, it prevents them from being able to utilise technology that can be extremely empowering, in this case, for their pregnancy.

NIPS is not novel anymore. Yet, there are still OB-GYN providers out there who are reticent to incorporate it into their routine screening programmes for whatever reasons.

So one of the things that we have really wanted to do at Juno is work together with our providers, colleagues and partners, to try to equip them with the resources that they need to help their patients get the information that’s right for them and to ultimately, make an informed decision.

How does your approach help women access pre-natal screening tests at home?

KS: We’ve designed an extremely personalised approach because we really want to be meeting people right where they are.

At present, for the non-invasive prenatal screening test, there are two different pathways that people can follow.

They can either request the test themselves and a physician will review the order request and approve it, or their provider can order the test for them.

Once the order is placed, the patient is prompted to set up a Zoom call for a sample collection. This is going to be the same whether they’re doing the non-invasive prenatal screening test or the foetal gender test.

After the actual sample collection, patients are equipped with everything they need to return the kits. They just have to send them to the lab.

After we analyse the sample, they can access their results in their myJuno account.

What’s really unique is that our platform keeps them informed every step of the way, similar to how they might be used to tracking an order.

ME: We always wanted to empower women and encourage them to do things at their own pace. They have all the information they need on the platform and if something isn’t clear, they can get in touch with a genetic counsellor at any time of the process.

However, the platform is not a replacement for their OB-GYN provider. It’s something that’s intended to complement those services and make everybody’s life easier.

A lot of people were introduced to at-home testing during the pandemic. Do you think Covid has changed the way people view digital health?

KS: I think that prior to 2020, especially in the genetic counselling space, the whole concept of telemedicine was still intriguing. Covid has definitely changed that.

However, I think there are still challenges in the United States pertaining to our maternal health crisis and our OB-GYN access that telehealth on its own is not going to instantly fix.

ME: I think the pandemic did bring about a pretty big shift in the minds of the providers and they started to become more open to things like telehealth and taking care of patients remotely.

You’ve launched three products in 2022. What feedback have you received so far?

KS: The feedback has been exceptionally positive. I have been helping out with some of the Zoom calls on the collection side and people really appreciate the kind of support that we offer.

First of all, they like the fact that they’re talking with a real person in real time, but they also like that when they have questions, they don’t feel like a burden, and they can seek help and express their concerns.

Currently, the tests are only available in the US. Are you considering expanding your services globally?

ME: We’re extremely proud of all the work that we did in 2022. Yes, as we continue to grow, we’re considering expanding beyond the US when the time is right and in a way that is most appropriate.

It’s not Europe! I think Europe will be on our list at some point as well, but it is a little bit more difficult since most European countries have very particular healthcare systems to navigate. We promise it’s something exciting, though!

For more info, visit junodx.com.

Fertility

France urges 29-year-olds to start families now

Published

on

France is urging 29-year-olds to have children as part of a 16-point plan to boost fertility and raise birth rates.

Health officials say the aim is to prevent men and women facing fertility problems later in life and thinking “if only I had known”.

The strategy comes as the country, like many western nations including the UK, faces tumbling birth rates.

The trend is creating concerns about how governments can fund pensions and healthcare for ageing populations with fewer younger working people paying taxes.

But policies to raise fertility rates globally have produced limited results, and critics of the scheme suggest better housing and maternity provision could be more effective.

The government will send out “targeted, balanced, and scientifically sound information” to young people on issues including sexual health and contraception.

The material “will also reiterate that fertility is a shared responsibility between women and men,” the country’s health ministry said.

The plan includes efforts to increase the number of egg-freezing centres from 40 to 70. The process involves extracting and storing a woman’s eggs for potential future use.

The country’s health system already provides free egg-freezing for people aged 29 to 37, a service that costs about £5,000 per round in the UK.

The country’s fertility rate of 1.56 children per woman is below the 2.1 needed to maintain a stable population.

However, it is higher than rates in China, Japan and South Korea, and the UK, where the latest figures show it dropped to a record low of 1.41 in England and Wales by 2024.

Professor François Gemenne, who specialises in sustainability and migration at HEC Paris Business School, told Sky News: “This is something that demographers had known for a long time, but the fact that there were more deaths than births in France last year created a shock effect.”

He said the country’s “demographic worry” is exacerbated by the design of its pensions system and its “obsession with immigration and the fear of being ‘replaced'”.

The plan also includes a new national communication campaign, a “My Fertility” website advising on the effects of smoking, weight and lifestyle, and school lessons for children about reproductive health.

The health ministry has acknowledged its maternal and infant mortality rates are higher than neighbouring countries and is beginning a review of perinatal care to address the “concerning” situation.

Channa Jayasena, professor in reproductive endocrinology at Imperial College London, told Sky News: “On the female side, societal changes leading to older age of motherhood are certainly important.

He said obesity was also a problem as it increased women’s risk of polycystic ovary syndrome and endometriosis.

Allan Pacey, professor of andrology (male reproductive health) at Manchester University, said for most people globally, deciding to have children was “down to [non-medical] factors such as better access to education, career opportunities, taxation, housing, mortgages, finance, etc.”

“Medicine can’t help with those things,” Pacey added.

Continue Reading

Insight

Pregnancy and breastfeeding linked to higher cognitive ability in postmenopausal women

Published

on

Pregnancy and breastfeeding are linked to stronger cognition in postmenopausal women, a long-term study suggests.

Greater cumulative time spent pregnant and time spent breastfeeding correlated with higher overall scores in the study, including verbal and visual memory, in later life.

Researchers analysed annual assessments of more than 7,000 women aged about 70 for up to 13 years using data from the Women’s Health Initiative Memory Study and the Women’s Health Initiative Study of Cognitive Aging.

On average, those who were pregnant for around 30.5 months were expected to have a 0.31 per cent higher global cognition score than those who had never been pregnant.

A lifetime average of 11.6 months of breastfeeding was linked to a 0.12 per cent higher global score.

Each additional month spent pregnant was associated with a 0.01-point rise in overall ability.

Each extra month of breastfeeding showed the same increase, and a 0.02-point gain in verbal and visual memory. Although small, these effects are similar to known protective factors such as not smoking and high physical activity.

The work was led by Molly Fox, an anthropology professor at the University of California, Los Angeles.

Fox said: “Any ways in which we can focus public health outreach or clinical interventions towards higher-risk populations leads to more effective and efficient efforts.”

Participants who had ever been pregnant scored, on average, 0.60 points higher than those who had never been pregnant.

Those who had breastfed scored 0.19 points higher overall and 0.27 points higher for verbal memory than those who had never breastfed.

Women are disproportionately affected by Alzheimer’s disease, a progressive condition that impairs memory and thinking skills, and this is not fully explained by life expectancy differences.

The authors say biology and social factors may both play roles.

They noted that more adult children could contribute to cognitive health by buffering stress, supporting wellbeing or encouraging healthy behaviour.

“If we can figure out, as a next step, why those reproductive patterns lead to better cognitive outcomes in old age, then we can work towards figuring out how to craft therapies, for example, new drugs, repurposed drugs or social programmes, that mimic the naturally occurring effect we observed,” said Fox.

The study team is now working to identify the mechanisms that link reproductive histories to cognitive resilience.

Continue Reading

Pregnancy

Stroke prevention and treatment during and after pregnancy key to women’s health – AHA

Published

on

Stroke prevention requires aggressive blood pressure control and rapid recognition of symptoms in pregnancy and postpartum, a new scientific statement urges.

The guidance details risk factors for pregnancy-related stroke and offers suggestions for prevention, rapid diagnosis, timely treatment and recovery during pregnancy and postpartum.

A stroke occurs in approximately 20 to 40 of every 100,000 pregnancies and is estimated to account for around four to six per cent of pregnancy-related deaths annually in the US.

The statement was published by the American Heart Association and endorsed by the American College of Obstetricians and Gynecologists.

Eliza Miller is chair of the writing group and associate professor of neurology at the University of Pittsburgh.

She said: “When a stroke occurs during pregnancy or the postpartum period, it can lead to serious complications for both the mother and baby, including neurological deficits, long-term disability, increased risk of future strokes and death.

“Controlling blood pressure and other stroke risks before and after delivery, responding immediately to stroke warning signs and providing timely treatment can help save lives and improve outcomes for mothers and their babies.”

There are two types of stroke: an ischaemic stroke occurs when a blood vessel supplying blood to the brain is blocked by a clot, while a haemorrhagic stroke occurs when a blood vessel ruptures and bleeds into the brain.

Risk factors for pregnancy-associated stroke include chronic hypertension (high blood pressure before pregnancy or diagnosed before 20 weeks), preeclampsia (a dangerous condition causing high blood pressure in pregnancy), advanced maternal age (35 years or older), diabetes, obesity, migraine with aura, infections, heart disease and clotting disorders.

Stroke disproportionately affects people of racial and ethnic minorities. A 2020 meta-analysis found that pregnant Black women are twice as likely to have a stroke compared with pregnant white women, even after adjusting for socioeconomic factors.

The statement authors emphasise that the majority of maternal strokes are preventable with earlier and more aggressive blood pressure control.

“Preeclampsia and eclampsia can occur before, during or after delivery, and the early postpartum period is actually the highest risk time for stroke.

“Very close monitoring of blood pressure is essential,” said Miller.

The statement urges all healthcare professionals who care for pregnant patients, including obstetricians, family medicine practitioners and nurses, to be trained to recognise stroke symptoms so they can promptly start treatment.

“It is crucial for women who are pregnant or have recently given birth and have symptoms of new neurological deficits or severe headache, especially if they also have elevated blood pressure, to be immediately evaluated for possible stroke,” said Miller.

The authors emphasise that pregnancy is not a reason to delay or interfere with recommended treatment for acute stroke.

Various anti-clotting medications are available that are safe for pregnant and lactating women, and mechanical thrombectomy (surgical removal of a blood clot) may be needed for patients with large-vessel blockages.

Survivors of pregnancy-associated stroke face unique challenges such as caring for an infant and require support from a multidisciplinary rehabilitation team.

Mood and sleep disorders are common after stroke and may be intensified by postpartum factors such as hormonal shifts, breastfeeding and disrupted sleep.

Miller said: “Babies depend on their mothers’ well-being, and supporting recovery after stroke, both emotionally and practically, is essential so mothers can heal and families can thrive.”

Continue Reading

Trending

Copyright © 2025 Aspect Health Media Ltd. All Rights Reserved.