News
Plume secures US$24m to advance healthcare for the transgender community
The visibility of the trans community is growing at an exponential rate as younger generations openly identify as trans
A US virtual care provider designed for the healthcare needs of the transgender community has announced its Series B funding round of US$24m.
Plume aims to use the resources to expand coverage nationwide and provide better support to trans and gender diverse people and their families deserve.
“As a trans woman and physician, I started Plume to offer a supportive space for trans Americans as they navigate our nation’s broken health care system,” said Dr Jerrica Kirkley, Plume’s co-founder and chief medical officer.
“With this announcement, we are on track to reach our goal of increasing access to high-quality, gender-affirming care to patients across the US in both urban areas and coverage deserts.
“Knowing the hurdles trans Americans face when accessing care, I’m encouraged to reach this benchmark and I look forward to Plume’s growth in the future. I want to thank Transformation Capital, General Catalyst, and Town Hall Ventures for their partnership in transforming health care for every trans life.”
The visibility of the trans community is growing at an exponential rate as younger generations more readily openly identify as trans and gender diverse.
Gen Z – the generation born between 1997 and 2012 – identify as trans at nearly four times the rate of baby boomers and is statistically the queerest generation in history.
Trans individuals have unique medical, legal, and socio-emotional needs distinct from those of the broader cisgender LGBQ+ population that are commonly unmet by the status quo.
Dr Matthew Wetschler, Plume’s co-founder and chief executive officer said: “Since launching in 2019, Plume has strived to bring the trans community the deeply personalised healthcare they deserve.
“Amidst growing anti-trans rhetoric nationwide, Plume’s model offers unmatched access to healthcare for trans Americans. This announcement only reinforces our goal of expanding that coverage and eliminating barriers to quality care.”
In the US, more than 30 per cent of trans people avoid healthcare for fear of discrimination and more than 60 per cent of those in urban areas have had to access medications outside of the clinical system.
Plume members pay US$99 a month and receive 24/7 access to gender-affirming care, personal consultations, lab testing, support groups, medical letters of support for surgery and name and gender marker changes, and home delivery of prescriptions and gender-affirming medication as medically appropriate.
The company aims to eliminate these barriers by making gender-affirming care accessible for anyone who needs it without having to go to a doctor’s office.
Current research suggests that transgender women are likely to suffer significant health disparities and may require medical intervention as part of their care.
Despite increased transgender awareness, real or perceived stigma and discrimination within biomedicine and the healthcare provision may impact many transgender people’s desire and ability to access appropriate care.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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