News
Oma Fertility introduces shared egg freezing programme to support aspiring parents
Patients who freeze their eggs and donate a portion will be offered the procedure at no cost
Oma Fertility has announced a shared egg freezing programme to “democratise” access to egg freezing services and meet growing demand for egg donors.
The programme will enable patients in the US to freeze and store their eggs for free, including medications, and donate a portion of the eggs retrieved to the the clinic’s egg donor programme to help others on their journey to parenthood.
Those who make a donation will receive the entire procedure at no cost.
The programme is being introduced at a time when egg freezing services are in high demand and the need is greater than ever.
The American Society of Reproductive Medicine (ASRM) estimates egg freezing increased a staggering 2,695 per cent from 2009 to 2018 and shows no signs of slowing down.
By 2025, almost 10 million couples will encounter problems having a baby, and approximately 20 per cent will rely on IVF over the next two decades.
Today, the national average cost for one complete cycle of egg freezing, including ultrasound monitoring, doctor supervision, and injectable medications, is upwards of US$14,000, not including the supplemental, annual cost for egg storage which can range anywhere from US$500 – US$1,000 per year.
Gurjeet Singh, co-founder, and CEO of Oma Fertility, said: “We understand these costs are out of reach for many.
“Our empathetic approach to affordable and accessible fertility care through programs like this provides our patients with the opportunity to plan for their own family while making parenthood a possibility for those who aren’t able to conceive on their own.”
Those who wish to apply for the programme must complete a donor application and an initial doctor consultation. If accepted, the US$9,500 egg freezing procedure, with five years of storage, will be offered at no cost.
Oma Fertility opened its first fertility clinic in Santa Barbara, California, in 2021 and has plans to expand nationally through 2023.
Last month the company announced a partnership with the digital pharmacy service Alto to offer prescription delivery and telehealth services to support patients through “strict and intimidating medication regimens”.
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Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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