News
NHS approves ‘life-saving’ AstraZeneca drug for breast cancer
Around 300 women in England with HER2-negative early breast cancer will be eligible for the new drug each year
Hundreds of breast cancer patients in England could benefit from a breakthrough targeted therapy, following an NHS commercial deal with AstraZeneca.
The drug targets cancer patients with the BRCA gene, also known as the “Jolie gene” after Hollywood actress Angelina Jolie opted for a double mastectomy in 2013 after testing positive for the gene.
Olaparib works by stopping cancer cells from being able to repair their DNA by blocking a molecule called PARP, which causes the cancerous cells to die.
Around 300 women with HER2-negative early breast cancer who are at high risk of the disease returning, will be eligible for this new drug each year in England.
Clinical trials showed that giving olaparib after chemotherapy reduced the relative risk of the disease returning within four years by nearly a third.
The National Institute for Health and Care Excellence (Nice) opted last year not to recommend olaparib for breast cancer patients because of its high cost. But after NHS England negotiated a commercial deal with AstraZeneca, the watchdog has reversed its decision.
Amanda Pritchard, NHS chief executive, said the landmark deal is incredible news for patients and their families.
“Olaparib could have a huge impact on patients with a range of cancer types, giving many a better chance of survival while offering those with advanced forms of the disease precious extra months to live.”
Baroness Delyth Morgan, chief executive at Breast Cancer Now, said: “It’s fantastic news that olaparib, which is a ground-breaking and potentially life-saving treatment for certain people with primary breast cancer, has now been approved for use on the NHS.
“Around five to ten per cent of women with breast cancer carry an inherited altered gene of which the BRCA 1 and 2 genes are the most common. Sadly, some people with high-risk, HER2 negative primary breast cancer with an altered BRCA gene – often known as the ‘Jolie gene’ – may see their cancer return following treatment.
“Crucially, olaparib can reduce the risk of people’s cancer returning or progressing to incurable secondary breast cancer and stop people dying from this devastating disease”.
Health Minister, Helen Whately, added: “For hundreds of people with cancer and their families, today offers the hope of more precious time with loved ones.
“We are committed to providing world-class cancer care to patients and are always working together with clinicians to find new, cutting-edge treatments.”
David Brocklehurst, head of oncology at AstraZeneca UK, said: “We know how devastating a diagnosis of either of these hard-to-treat, aggressive cancers can be, for patients and their loved ones. Until now, treatment options for cancers resulting from BRCA mutations have been extremely limited.
“The availability of olaparib, a treatment discovered and developed in the UK, makes us extremely proud.
“Treatment innovations such as these underscore our bold long-term ambition to eliminate cancer as a cause of death”.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
Insight
Higher nighttime temps linked to increased risk of autism diagnosis in children – study
Entrepreneur
Kindbody unveils next-gen fertility platform
-
Wellness4 weeks agoDesigner perfumes recalled over banned chemical posing fertility risk
-
Insight2 weeks agoParents sue IVF clinic after delivering someone else’s baby
-
Insight3 weeks agoWomen’s health could unlock US$100bn by 2030
-
Insight4 weeks agoChina’s birth rate hits record low despite government fertility efforts
-
Hormonal health3 weeks agoHRT linked to greater weight loss on tirzepatide
-
Hormonal health6 days agoUS startup builds wearable hormone tracker
-
Menopause2 weeks agoFlo Health and Mayo Clinic publish global perimenopause awareness study
-
News4 weeks agoVerdane invest in Clue to accelerate the future of women’s health






