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Psilocybin may make postpartum depression worse, study finds

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Psilocybin may heighten anxiety and depression in new mothers rather than help treat postpartum mental health conditions, research suggests.

Scientists found that giving mouse mothers the psychedelic drug – the active compound in magic mushrooms – increased anxiety and depressive-like behaviour linked to perinatal mood disorders, which are mental health conditions that can develop during or after pregnancy.

The results challenge assumptions about psilocybin’s therapeutic use, indicating it may not be suitable for all patient groups.

David E. Olson, director of the IPN and professor of chemistry, biochemistry and molecular medicine at UC Davis, said: “The IPN has done a lot of work demonstrating that a single dose of a psychedelic can lead to long-lasting, beneficial effects.

“But it’s a little more nuanced than that in terms of who can really benefit and who might be at risk.

“There are different patient populations.”

Researchers at the University of California, Davis Institute for Psychedelics and Neurotherapeutics tested the drug in a mouse model of postpartum depression.

In this model, mothers could escape into a separate cage, mimicking the infant avoidance seen in human postpartum depression.

The negative effects persisted for two weeks after a single dose.

More concerning, pups raised by psilocybin-treated mothers also showed anxiety and depression-like symptoms into adulthood, suggesting harmful effects were passed on through lactation and altered brain development.

Co-author Danielle Stolzenberg, associate professor of psychology at UC Davis, said: “One of the things that’s discussed consistently in the clinical literature is that mums often feel like they have trouble bonding with their infants when they’re experiencing depressive symptoms.

“The mouse mums in the social stress paradigm spend significantly more time in the cage without the pups.

“They will often run back and forth to check on them but tend to actively avoid their infants for long periods of time.”

The team had expected positive results given psilocybin’s reported benefits for other mental health conditions.

“Psilocybin was of such interest for us because it’s been demonstrated to be useful across a whole host of mental disorders, including addressing anxiety and depression,” said first author Cassandra Hatzipantelis, a postdoctoral fellow at the IPN.

“We thought it could have the ability to address things that go wrong in postpartum depression, like the parent-infant connection.”

Instead, the mouse mothers continued to avoid their offspring and showed persistent symptoms even after separation.

Psilocybin-treated mice were also at higher risk of behavioural impairments and depressive-like symptoms.

Nine weeks after weaning, both male and female offspring showed heightened anxiety and depression compared with control groups.

Their brains also contained traces of psilocin, the metabolite produced when the body processes psilocybin.

“We now know that even low doses of exposure can impact offspring for long periods of time,” Stolzenberg said.

“These could be really important therapeutics, but we also realise they have limitations, and we have to conduct rigorous science to understand what those limitations are,” Olson added.

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Resistance training has preventative effects in menopause, study finds

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Resistance training improves hip strength, balance and flexibility during menopause and may also improve lean body mass, research suggests.

A study of 72 active women aged 46 to 57 found those who completed a 12-week supervised programme saw greater gains than those who kept to their usual exercise routines.

None of the participants were taking hormone replacement therapy.

The supervised, low-impact resistance exercise programme focused on strength at the hip and shoulder, dynamic balance and flexibility.

Participants used Pvolve equipment, including resistance bands and weights around the hips, wrists and ankles, and also lifted dumbbells of varying loads.

Women in the resistance training group showed a 19 per cent increase in hip function and lower-body strength, a 21 per cent increase in full-body flexibility and a 10 per cent increase in dynamic balance, meaning the ability to stay stable while moving.

Those in the usual activity group did not show any significant improvements.

Previous studies have assessed the decline in lower limb strength and flexibility during menopause, but this is said to be the first study to compare the effect of resistance training on muscle strength and mass before, during and after menopause.

This was done by including participants in different phases of menopause rather than following the same participants over a long timeframe.

Francis Stephens, a researcher at the University of Exeter Medical School in the UK, said: “These results are important because women appear to be more susceptible to loss of leg strength as they age, particularly after menopause, which can lead to increased risk of falls and hip fractures.

“This is the first study to demonstrate that a low-impact bodyweight and resistance band exercise training programme with a focus on the lower limbs, can increase hip strength, balance, and flexibility.

“Importantly, these improvements were the same in peri- and post-menopausal females when compared to pre-menopausal females, suggesting that changes associated with menopause do not mitigate the benefits of exercise.”

Although one of the researchers sits on Pvolve’s clinical advisory board, the researchers said the company did not sponsor the study or influence its results.

Stephens added that any progressive resistance exercise training focused on lower-body strength is likely to yield the same results.

He said: “The important point is for an individual to find a type of exercise, modality, location, time of day etc., that is enjoyable, sustainable, and improves everyday life.

“The participants in the present study reported an improvement in ‘enjoyment of exercise,’ and some are still using the programme since the study finished.”

Kylie Larson, a women’s health and fitness coach and founder of Elemental Coaching, who was not involved in the study, said the results were compelling.

She said: “This is particularly exciting for those that tend to think of menopause as ‘the end’. The study proves that if you incorporate strength training you can still make improvements to your muscle mass and strength, which will also have a positive ripple effect to your ability to manage your body composition.

“In addition, staying flexible and being able to balance are both keys to a healthy and functional second half of life.”

Participants in the study did four classes a week for 30 minutes each session, but Larson said even half that amount of strength training can go a long way, particularly if you emphasise progressive overload, which means gradually increasing muscle challenge through more weight.

Larson said: “Gradually increasing the challenge is what drives real change.

“Lifting heavier over time is what builds strength, protects your bones, and keeps your body resilient through menopause and beyond.”

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France to reimburse young women for cost of reusable period products

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France will reimburse reusable period products for women under 26 and those on low incomes, in a move aimed at tackling period poverty.

The measure is expected to help 6.7m people, almost a tenth of France’s population of 69m, from the start of the next academic year in the autumn.

Women under 26 with a state health insurance card, as well as women of all ages who receive special healthcare support because of limited income, will be able to claim reimbursement after buying the products from a pharmacy. The cost will be covered through the country’s social security system.

Parliament approved the measure as part of the country’s social security budget for 2024. However, no decree was issued to bring it into force, prompting anger among feminist groups and companies making the sustainable sanitary items.

A survey of 4,000 women in France in November found that one in ten had used alternatives to mainstream period products, such as ripped-up clothes, because of tight budgets, according to French charity Dons Solidaires.

France cut sales tax on period products from 20 per cent to 5.5 per cent in 2016. In 2020, Scotland became the first country in the world to sign into law free universal access to period products in public buildings.

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Condé Nast to close women’s health magazine after 47 years

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Condé Nast will close its women’s health publication Self after 47 years, with unprofitable editions of Glamour and Wired also set to shut.

In a memo published on the magazine giant’s website on Thursday, the media company’s chief executive, Roger Lynch, said: “As audience behaviours shift, we have not seen a path for Self to continue in its current form as a digital publication.”

“Going forward, health and wellness content will be integrated into our other brands, including Allure and Glamour,” Lynch said, referring to Condé Nast’s other beauty and wellness titles.

Self, which moved to an online-only format in 2017, still reaches more than 20m people each month.

The publication has also earned significant recognition over the years, including a National Magazine award and a Webby’s People’s Voice award.

The closure is part of a wider set of operational changes across the company. Lynch also announced the end of Wired’s Italy edition, noting that while the brand “remains a strong global brand, the Italian edition has not kept pace with growth in our other markets”.

Condé Nast will also wind down Glamour’s publishing operations in Germany, Spain and Mexico.

Lynch said: “Taken together, Wired in Italy, Self and the affected Glamour markets represent a little over 1 per cent of our overall revenue.

“They also remain unprofitable, and continuing to operate them in their current form limits our ability to invest in the ideas and areas that will drive future growth.”

Beyond editorial changes, the company is also restructuring internally to adapt to technological shifts.

Lynch said Condé Nast would make “changes within our technology organisation, reflecting the rapid advancement of AI and its impact on our ability to innovate and build products faster”, adding: “Teams will be restructured to be more agile and to work more closely with our brands and customers, reducing barriers to execution.”

The latest moves follow a series of transformations at Condé Nast in recent years.

Glamour ended its print edition in 2018, followed by Allure moving to a digital-only format in 2022.

In 2024, music publication Pitchfork was folded into GQ, the company’s men’s style magazine.

More recently, last November, Vogue, one of Condé Nast’s key revenue drivers, announced it would absorb Teen Vogue to create a more “unified reader experience across titles”.

The media industry has been shrinking steadily over the years.

From 2010 to 2017, the industry lost an average of 7,305 jobs annually, according to data from Challenger, Gray & Christmas published in December 2025.

Since 2018, the average number of job cuts in the industry has risen to 14,298 a year.

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