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Mental health

Childhood abuse may leave gene activity changes linked to depression

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Childhood abuse may alter gene activity in some women, raising depression risk, UK Biobank analysis suggests.

The pattern was not seen in men, suggesting the biological links between trauma and depression may differ by sex, an area of interest given higher depression rates among women.

Using data from thousands of people in the UK Biobank, the team analysed childhood experiences, mental health and genetic profiles, focusing on a gene network involved in synaptic function, the way brain cells communicate, which is disrupted in depression.

Researchers at McGill University and the Douglas Mental Health University Institute examined this network and found that, among women who experienced childhood abuse, one configuration was linked to a higher risk of depression.

Senior author Patricia Silveira is professor in McGill’s Department of Psychiatry and researcher at the Douglas Mental Health University Institute.

She said: “We know childhood abuse increases the risk of depression at the population level, but at the individual level it’s much harder to predict who will actually develop the disorder.

“Our findings point to a biological mechanism that may help explain who is more at risk, at least in women.”

The work is part of efforts to identify genomic signatures linked to depression risk, which is estimated to affect around 11 per cent of Canadian adults over their lifetime.

Our findings suggest that depression risk is shaped by how genes involved in synaptic function respond to early-life experiences.

That makes synaptic function a promising target for future research,” said co-first author Carla Dalmaz, a visiting professor at the Douglas from the Universidade Federal do Rio Grande do Sul.

“Depression is diagnosed primarily based on reported symptoms, and there are still no widely accepted biological tools in routine clinical practice to identify risk early,” added co-first author Danusa Mar Arcego, a research associate at the Douglas.

“Our findings bring us a step closer to understanding why some people may be more vulnerable, opening the door to earlier support and prevention strategies.”

Mental health

Tackling women’s mental health with music and tech

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By Tuned Global

Mental health problems affect both men and women, but not in equal measure. According to the Mental Health Foundation, one in five adults has a common mental health condition: about 24 per cent of women and 15 per cent of men.

The Mind Organisation also reveals women are more likely to have suicidal thoughts and to make suicide attempts than men. So how can music therapy help?

At a recent industry event, audiences attending a session on music in the medicine and research space gained insights into the therapeutic benefits of music, such as treating conditions including dementia, Parkinson’s disease, PTSD and ADHD. 

Three experts sat down to discuss this exciting and complex space and to explore how in trying to bring these treatments to patients or the broader market, the not-so-common intersection of medtech and music surfaces a number of challenges. 

How AI can strengthen music therapies

                             Felicity Baker

Music therapy itself is not new, and therapists have been delivering such interventions in one-on-one sessions and small groups for decades.

The exciting prospect highlighted during the session was that technology and AI can now enable this at scale and with evidence-based approach. 

If more people can gain access to music treatment through technology, there is the potential to decrease medication intake, reduce healthcare costs and improve outcomes.

However, scaling these therapies does introduce new considerations and challenges that traditional clinical settings have not had to face. 

Felicity Baker is a music therapist, professor at the University of Melbourne and Founder of Matchplus.ai, a sensor-based AI solution that detects early physiological markers of agitation and delivers personalised music interventions to improve the wellbeing of people living with dementia and other cognitive conditions.

With over three decades of experience in dementia care and music therapy, Baker is leading this project at prototype stage to reduce distress, medication reliance and create a more enabling environment for individuals with cognitive decline.

Having successfully secured USD $1.3m from Google.org (the philanthropic arm of Google LLC) to develop scalable technology, Baker has become one of just 15 recipients worldwide from more than 800 applications.

“We’re using wearables to actually develop algorithms that can predict when someone is going to start wandering or is going to get up and have a fall or hit another resident in the nursing home,” she said. 

“We’ve got it down to between five and 15 minutes, so a carer or family member can anticipate that something’s going to happen.”

Baker said using AI to help preempt when to use music was one thing, but then what order the music should come in, what kind of music and how to be sensitive to the specific symptoms of people with dementia created further challenges they continue to work on.

Simone Dalla Bella, co-director of the BRAMS laboratory at the University of Montreal is conducting research focused on rhythm interventions for patients with various disorders, including Parkinson’s disease.

                             Simone Dalla Bella

The interventions include rhythmic serious games such as Beat Workers, and mobile apps such as BeatMove, developed by the start-up BeatHealth that Dalla Bella co-founded.

For example, BeatMove can adjust music tempo to help Parkinson’s patients walk more effectively. 

“Imagine that you have music in the background that you chose, and the music is going a bit faster than you, so it motivates you to run a bit faster.

“But then if you’re tired and you slow down, the music will follow you gently as if you were running or walking with a theoretical partner,” he said. 

“A clinical trial is currently ongoing in France to test a large group of patients with Parkinson’s who basically take the app outside in a park, they use it, and we are seeing beneficial effects of that kind of intervention.”

Navigating music licensing challenges

The prospect of music-powered therapy is rather inspiring and life-affirming. Providing outcomes for patients with debilitating conditions in a non-invasive way is certainly a noble cause for academics and entrepreneurs alike to take up.

However, what many might not have considered is how these medical applications acquire and manage music rights. 

Virginie Chelles, VP and Global Head of Marketing and Communications for music licensing and technology company Tuned Global, described the complexity facing these innovators.

In working with medical technology clients, Chelles highlighted that while founders deeply understand the science and tech behind their products and projects, they often have no knowledge of music industry operations.

“When it comes to us, there is a whole new industry, being the music industry which has little or no connection with the medical industry, [which in itself also] has a lot of regulation,” she said.  

In the medical music space, Tuned Global currently works with MediMusic, a UK startup that uses AI to analyse brain responses and select music for anxiety and pain management.

Companies like MediMusic are obviously performing powerful and important work, but in cases where they are not up to speed on all of the requirements to correctly licence music, they are adding layers of risk to an already compliance-heavy environment. 

                           Virginie Chelles

“They’re dealing with the legal side of medicine in being able to have it delivered in NHS Hospitals in the UK, and going for trials and all that is involved.

“There is a lot of paperwork to do there,” Chelles said. “But then, if they play the wrong track, [a] track that was not licensed, the business is in trouble.”

“[They would be looking at lawsuits], and they wouldn’t be paying the rights to the right people. There are master rights, there’s publishing rights. [So they think], ‘How do I do that? How do I find the right tracks?’.” 

Often in these kinds of apps, an AI personalisation solution will drive the selection of tracks that resonate with certain patients, so another challenge for medtech clients in knowing the extent of what other tracks they will need access to.

Companies must also consider whether their licenses permit training medical algorithms on music assets. 

“Thousands of tracks are released every day, and [if you look at what’s being produced] with AI. It’s even more,” she said. 

“Many companies don’t need millions of tracks. If you work on dementia, just working on a back catalogue, like the catalog that makes sense for these people when they were in their 20s. 

“For us, it helped us to understand what you need to license the right catalog, rather than millions of tracks, because accessing millions of tracks is a lot of money in storage and in processing.” 

Understanding music licensing early in the innovation process

For medtech companies wanting to leverage music, Chelles was direct about the challenges and decisions they face when they first approach music licensing.

A lot of consideration needs to be made about how much music they need, what kind, whether they need commercial music or production music and more. 

When MediMusic first engaged Tuned Global, these considerations presented a big challenge.

“Because licensing music is not a science. It’s not predictable, but we can definitely help,” she said. 

Elaborating further, Chelles said that companies tended to be more successful when they addressed music licensing early in development rather than treating it as an afterthought.

“It’s going to take as much time to build the music and the licensing and compliance technology as building your medical device or app or science behind it,” 

“Talk to a music expert early on, it can be us, but it can also be entertainment lawyers or licensing specialists that are going to be able to help from the beginning … to just understand what it is about.

“We can also help them to build their business case to pitch to those labels, because this can be quite strategic depending on the label and their current objectives.

“Making big pitches without understanding them or the broader environment could cost a lot of time and money if they don’t sign you up right away.

“Being able to demonstrate and communicate value in this industry on the industry’s terms is really important for success, so if you can work with people that have these relationships and can engage with them it’s very helpful.” 

Working with an established music technology company can help medtech startups navigate label negotiations. Labels recognise that companies already working with licensing specialists have typically secured funding and understand the commercial requirements.

“[The labels are] like, okay, they are legit, because if Tuned Global can work with them, they already have the funding and they understand what they’re doing,” Chelles said. 

Securing licensing agreements is only the first step. Companies then need backend technology to access the actual tracks.

Tuned Global maintains 190 million tracks, with the catalog growing daily.

Companies must negotiate separately with both master rights holders (the record labels) and publishers who represent musicians and writers.

Commercialising research and innovation

Neither researcher came from a background that prepared them for music industry negotiations.

Despite publishing in The Lancet and Nature and securing major medical research grants, Baker found music licensing remained unfamiliar territory.

Dalla Bella received more than $USD 3.5m in European research funding but similarly had no training in navigating music rights.

Startup activity at universities is growing, but this has not always been the case.

Baker noted that while the institutions themselves were very supportive and really wanted to push research innovations into the market, there still exists some commercialisation stigmas among some researchers. 

“For some researchers, commercialising your research is kind of almost like a dirty word.

“To them it’s like you’re not being true to the science if you want to actually make a company and do something with this,” she said. 

Dalla Bella described how moving from pure research into commercial applications required stepping outside his comfort zone.

“Sometimes in science, we’re very closed, right?

“We do work just in science, in our niche, we are happy with what we do, but then you have to go beyond your comfort zone to start to work with engineers and start to work with a startup company,” he said.

“[I’ve seen for a lot of people] it took time to build this collaboration, this common language, and to be able to work together. After a certain amount of time, you discover the real potential of doing that.”

The future of tech powered music therapies

The medical music technology sector is an exciting and expanding space.

As more innovators enter the industry, the intersection between healthcare regulation and music licensing will likely require more standardised frameworks and understanding of the complexities so they aren’t bogged down or exposed to complications that could cut their journey to provide care short.

For now, companies navigating both industries must build relationships with experts in each domain.

The medical science may be groundbreaking, but without proper music licensing infrastructure, therapeutic applications cannot reach patients or compensate the artists whose work makes treatment possible.

About Tuned Global

Tuned Global is the leading data-driven cloud and software platform that empowers businesses to integrate commercial music into their apps or launch complete streaming experiences using advanced APIs, real-time analytics, licensing solutions, and customisable white-label apps.

Our turnkey solutions for music, audio, and video — coupled with a broad ecosystem of third-party music tech integrations — make us the most comprehensive platform for powering any digital music project. We streamline complexities in licensing, rights management, and content delivery, enabling rapid innovation and bringing new ideas to life.

Since 2011, we’ve supported 40+ companies in 70+ countries — across telecom, fitness, media, aviation, and more — to deliver innovative music experiences faster and more cost-effectively.

For more information, visit www.tunedglobal.com.

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Menopause

Nearly three-quarters of UK women unaware menopause can trigger new mental illness

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Nearly three-quarters of UK women do not realise menopause can trigger a new mental illness, new research has revealed.

The findings have prompted what is described as the first targeted position statement on menopause and mental health from a major UK medical body.

A YouGov poll found only 28 per cent of women know a new mental illness can be linked to menopause, while 93 per cent associate it with hot flushes and 76 per cent with reduced sex drive.

The Royal College of Psychiatrists, which commissioned the poll and represents more than 20,000 psychiatrists, said the lack of awareness means many women may not seek help or receive appropriate care.

Dr Lade Smith, president of the Royal College of Psychiatrists, said: “Menopause can have a significant yet often overlooked impact on women’s mental health and wellbeing.

“Women account for 51 per cent of the population and all will experience menopause at some point.

“This is a societal issue for everyone. Simply put, we must do better.”

The report states that while anxiety and low mood are common during menopause because of hormonal changes, some women face a higher risk of more serious mental illness during perimenopause.

Women in this phase are more than twice as likely to develop bipolar disorder, a condition involving extreme shifts between elevated and depressed moods, and are 30 per cent more likely to develop clinical depression.

Hormonal and physical changes may also trigger eating disorders or cause a relapse, and suicide rates are higher among women of menopausal age.

Dr Cath Durkin, joint presidential lead for women and mental health at the Royal College of Psychiatrists, said: “For women with or at risk of bipolar disorder, perimenopause may represent a period of particular clinical danger that has historically gone unrecognised.”

The report also noted that women with bipolar disorder who experienced postnatal depression or premenstrual mood symptoms were at higher risk of relapse of depression during menopause.

The report calls for health services and governments across all UK nations to improve care, introduce mandatory teaching on menopause and mental health in medical and psychiatric training, and ensure workplace menopause policies address its relationship with mental health.

It comes as a study from University College London published in the Post Reproductive Health journal found that 58 per cent of black women in the UK said they felt completely uninformed about menopause, with many describing the experience as “psychologically damaging”.

More than half, 53 per cent, reported anxiety, yet many said they were misdiagnosed with anxiety or depression rather than menopause when speaking to their GP. #

As a result, only 23 per cent took hormone replacement therapy, or HRT, a treatment that uses hormones to ease menopausal symptoms.

Janet Lindsay, chief executive of Wellbeing of Women, said: “For too long, women’s symptoms have been dismissed or misunderstood.

“We fully support the call for better awareness, joined-up care, better workplace support and policies, and more research that will help ensure women are listened to and supported through menopause.”

A Department of Health and Social Care spokesperson said: “It’s unacceptable women are facing barriers to the care and support they need.

“We’re taking action, bringing a menopause question into NHS health checks, renewing the women’s health strategy, and investing an extra £688m in mental health services while recruiting 8,500 more mental health workers.

“Women now have access to a wider range of treatments alongside improved training for new doctors to help ensure faster diagnosis and support.”

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Menopause

Menopause tied to brain structure changes

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Menopause is linked to grey matter shifts in brain regions for memory and emotion, with poorer sleep and higher anxiety or depression, a study suggests.

The research analysed health data and brain scans from thousands of women across the menopausal spectrum in the UK Biobank database, finding what the authors described as “widespread associations” between hormonal status and brain architecture.

Specifically, the study identified smaller grey matter volumes, the tissue that contains most of the brain’s nerve cells, in the hippocampus, entorhinal cortex and anterior cingulate cortex.

These regions are involved in memory formation and emotional regulation.

The research was carried out by a team at the University of Cambridge.

Dr Joanne Langley, first author of the study, said: “Our findings show that menopause is associated with changes in brain structure, and that these changes are linked to mental health and sleep disturbance.”

She added that while such differences do not equate to neurodegenerative disease, they may represent a sensitive period of brain vulnerability.

However, the cognitive data told a subtler story.

Despite the structural changes, memory performance showed little difference after the researchers corrected for other variables, suggesting the brain may be compensating or that structural thinning has not yet reached a threshold that affects function.

The study also examined hormone replacement therapy (HRT), a treatment used to ease menopausal symptoms by replacing hormones.

Women using HRT showed lower grey matter volumes in some regions compared with both pre-menopausal women and post-menopausal non-users.

However, HRT users also reported more severe menopausal symptoms and poorer mental health, raising the possibility that women with a greater symptom burden are more likely to seek treatment.

Professor Ulrike Zühlsdorff, senior author, cautioned against drawing firm conclusions. “It is important to emphasise that this study is observational.

“We cannot conclude that HRT causes these brain changes.”

She said the design does not allow cause-and-effect conclusions, nor does it capture detail on formulation, dose, route or timing of HRT initiation, all variables known to influence outcomes.

Professor Barbara Sahakian, a co-author, highlighted the broader implications. “Menopause is a natural transition, but it can have significant effects on women’s mental health and wellbeing. Recognising this can help us to develop better support and treatment strategies.”

The authors have called for longitudinal studies, which follow the same individuals over time, to separate the effects of ageing from menopausal status and to explore whether these brain differences persist, stabilise or reverse.

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