News
MATTER launches women’s health accelerator to support start-ups
The accelerator aims to support hundreds of businesses and entrepreneurs in women’s health
A US healthcare incubator has launched a women’s health accelerator to advance solutions for menopausal women.
The inaugural cohort of the 51 Labs accelerator, launched by the Chicago-based company MATTER, will focus on advancing solutions to support women+ during menopause and perimenopause.
The name, 51 Labs, stems from the fact that women are 51 percent of the population, despite women+’s health being an underfunded and under-innovated sector.
Women+’s health has been categorised as a niche space, with only five percent of all the US digital health funding going to women+’s health startups.
Women+ spend seven-to-14 years in perimenopause and menopause and experience any combination of 34 different symptoms, including hot flashes, night sweats, mood and mental health changes, weight gain, brain fog, worsening memory, painful intercourse and more.
There has been relatively little innovation focused on menopause, and with 1.3 million US women+ entering their menopausal transition each year, this life stage seems prime for innovation.
Menopause is further compounded by disparate health outcomes for women+ who have been historically marginalised with Black women+ entering menopause earlier than white women+ and at risk of more intense symptoms.
“51 Labs is a new opportunity for entrepreneurs focused on solving women+’s health challenges to rapidly accelerate their progress,” said Steven Collens, CEO of MATTER.
“Our first year’s cohort, focused on menopause, will benefit greatly from the engagement with Astellas, Walgreens and our health system partners.”
The inaugural 51 Labs accelerator cohort will address the question ‘How might we empower and support women+ during their menopausal transition with innovative healthcare solutions?’.
The 2022 programme will have two tracks — one focused on menopause awareness and identification, and another on symptom and lifestyle management.
With Parkview Health and University of Chicago Medicine’s focus on providing accessible, integrated care for their diverse patient populations, both tracks will focus on sourcing solutions that address the needs of underrepresented women+.
Other partners include Astellas Pharma US, Walgreens, Parkview Health and University of Chicago Medicine.
Marni Allen, director of consumer healthcare futures at Walgreens, said: “We are deeply committed to making healthcare more equitable and accessible for everyone, everywhere.
“By joining the first cohort of 51 Labs, we will help courageous entrepreneurs advancing real innovation and change in women+’s health.”
Applications for the 12-week accelerator are now open. Participating start-ups will benefit from one-on-one mentoring with industry experts, workshops as well as interactive roundtable discussions and forums.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
Insight
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