News
Innovative technologies could boost IVF industry, says Frost & Sullivan report
The global IVF services market is expected to reach US$43.97bn by 2027, say analysts
New technologies and AI adoption could “revolutionise” the IVF industry, analysis from the market research company Frost & Sullivan has found.
The report on the global IVF services market suggests the IVF industry is anticipated to grow significantly, with a compound annual growth rate (CAGR) of 20.46 per cent, from US$17.37bn in 2022 to US$43.97bn in 2027.
Fertilising the egg outside the body is the process of IVF, which is the most prevalent and effective form of ART and contributes more than 95 per cent of the total ART revenue.
The practice of freezing eggs, sperm, and embryos for IVF is becoming popular, which has significantly increased the demand for IVF services.
“Implementation of artificial intelligence (AI) and other advanced technologies, such as preimplantation genetic testing (PGT) and mild ovarian stimulation, is revolutionising IVF services,” said Suchismita Das, healthcare research analyst at Frost & Sullivan.
“Further, these innovative technologies are attributed to increasing the success rate of IVF, leading to the rising adoption of fertility services.
“IVF tourism, as part of medical tourism, is currently a mega trend boosting the growth of IVF services.
“Asia-Pacific countries, such as India and Singapore, and European nations, such as Spain and Poland, are emerging as the most preferred destinations for IVF treatment to expedite the IVF services sector’s growth,” Das added.
Global in Vitro Fertilization Services Growth Opportunities is the latest addition to Frost & Sullivan’s healthcare research and analyses available through its leadership council, which aims to help organisations identify growth opportunities.
In the light of the new findings, the company advises IVF market participants to partner with IVF technology providers to implement technologies that empower embryologists with better decision-support capabilities and collaborate with oncology care providers to offer cancer-specific IVF services.
Analysts also recommend joining with insurance providers to include fertility treatments in health insurance plans as the number of infertility cases rises alarmingly in countries such as India, China and Japan.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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