News
Future Fertility appoints TMRW Life Sciences executive Louis Villalba to its board of directors
Villalba brings more than 30 years of industry experience in developing and commercialising innovative products and therapies
Toronto-based Future Fertility has added tenured industry executive Louis Villalba to their board of directors.
Future Fertility develops AI-based decision support tools to help optimise the fertility journey, with a focus on the oocyte – the human egg.
The company’s non-invasive oocyte assessment software is the first to deliver personalised AI-powered egg quality insights, paving the way for a new standard of care by empowering patients and providers with individualised predictions for blastocyst formation and live birth.
“We have big ambitions globally as we shift into commercial growth mode in 2023,” says Christy Prada, CEO of Future Fertility.
“Lou brings the perfect mix of industry and commercial experience to round out our board team. We are lucky to have the opportunity to learn from him as we further grow our work with fertility clinics and patients globally.”
Louis S. Villalba brings more than 30 years of industry experience in developing and commercialising innovative products and therapies.
Mr Villalba is currently serving as chief business officer at TMRW Life Sciences. Previously he served as chief executive officer of Genea Biomedx, EVP of Corporate Development at OvaScience, EVP of sales at Auxogyn / Progyny and EVP of Europe for Conceptus from 2004 to 2013 where he was part of the team that completed the $1.1B sale of the company to Bayer AG.
“Future Fertility has developed a very interesting and compelling technology, hitting an important niche in the market. They are the first and only commercially available AI product in the oocyte assessment space and have a clear first-mover advantage,” says Villalba.
“I look forward to working with Christy and the senior management team to focus on developing commercial strategies that make Future Fertility’s AI software a standard of care in reproductive health around the world.”
Villalba’s industry expertise complements Future Fertility’s current board of directors as the company rapidly grows its presence globally, combining Whitecap Ventures’ expertise in scaling technology start-ups, M Ventures’ experience in MedTech commercialisation and co-founder Rene Bharti’s global business experience.
For more info, visit futurefertility.com.

Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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