News
Freya Biosciences secures $10.4 million investment from Bill & Melinda Gates Foundation
Freya Biosciences has received a $10.4 million strategic investment from the Bill & Melinda Gates Foundation with $1.4 million additional financing from current investor Export and Investment Fund of Denmark (EIFO).
Freya Biosciences has confirmed that the funds will be used to develop microbial immunotherapies for the treatment of bacterial vaginosis (BV) to address pre-term birth and potentially other indications affecting maternal and newborn health.
Freya is developing microbial immunotherapies to regulate the immune system and inflammatory
responses in the vaginal tract using its DYSCOVER platform. The company has identified Lactobacillus strains that are capable of engrafting in the vaginal tract, displacing the existing dysbiotic vaginal microbiome and reducing key inflammation biomarkers.
To date the platform has yielded Freya’s lead candidate, FB301 for improving pregnancy success in IVF. Freya will now use the DYSCOVER platform to develop and bring to the clinic a microbial immunotherapy for BV.
BV is a common condition that occurs when the vagina is infected with bacteria, causing an imbalance in the local microbiome resulting in unpleasant but usually mild symptoms.
However, it can have serious consequences in pregnant women, raising the chance of premature rupture of membranes, preterm birth, intra-amniotic infection, low birth weight and miscarriage. BV is treatable with antibiotics, but often BV redevelops shortly after antibiotic treatment has been completed, eventually leading to chronic recurrence and increased inflammation in the reproductive tract.
BV is a critically underserved condition, with prevalence among women of reproductive age between 23 to 29 per cent and higher rates in certain low-and middle-income countries. Women in these regions face disproportionately high risks of preterm birth and associated complications, underscoring the global need for effective, accessible treatments.
Colleen Acosta, PhD, Chief Executive Officer of Freya Biosciences, said: “We are thrilled that the Bill & Melinda Gates Foundation has placed its trust and financing in Freya to address major unmet global health challenges.
“This is an important validation of our work and the potential of the DYSCOVER platform, enabling Freya to develop critically needed therapeutic candidates for women’s and infant health.”
Peter Bisgaard, Chairman of the Board of Freya Biosciences, added: “Freya’s mission is to develop innovative solutions that can transform the health outcomes for millions of women globally, including in low-resource settings.
“This strategic investment from the Bill & Melinda Gates Foundation empowers us to take on one of the most pressing issues in maternal and infant health – bacterial vaginosis, its associated inflammation and connection to preterm birth.
“We are committed to ensuring that the benefits of our breakthrough therapies extend to women everywhere.”
In connection with the financing, Chris Chen, Partner, Strategic Investment Fund at the Bill & Melinda Gates Foundation, will join the Freya Biosciences board of directors as an observer, effective immediately.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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