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Three global grants open for women’s health

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Applications open for three grants supporting women’s health research and AI, offering over US$1.3m across projects in cardiology, fertility and tech.

The American Heart Association will award up to US$1m across up to 10 one-year awards (US$100,000 each) through Redefining Women’s Health: From Heart to Head to Hormones. Priorities include ischaemia with non-obstructive coronary arteries and cardiovascular microvascular disease, autoimmune disease screening and care models, next-generation endometriosis treatments, and new classifications and care models for heavy menstrual bleeding. Ischaemia means the heart muscle receives too little blood despite no major artery blockage, while microvascular disease affects the heart’s small vessels.

Cardiovascular disease is the leading cause of death in women, and up to 50 per cent with angina show no obstructive lesions, an estimated 3–4 million women in the US. Pre-proposals are due 6 January 2026, full proposals 14 April 2026, with awards in June and funding from 1 July 2026. Studio Red will support awardees on IP, regulation, reimbursement, commercialisation and fundraising, with possible incubation for 1–2 teams. Applicants must be at US-based non-profits, hold a doctoral degree and be American Heart Association professional members.

IVI RMA Global’s Global Health Social Impact Award offers a US$50,000 grant to an existing non-profit project in reproductive or maternal health. Eligible organisations must operate in or partner with non-profits in the US, Spain, Italy, Portugal, Canada, UK, Sweden, Chile, Brazil, Panama, Czech Republic, Iceland or Denmark. Applications close 31 December 2025 for 2026 delivery, with review criteria covering health impact, scalability, equity, innovation, sustainability and mission fit. Shortlisted projects go to an employee vote, with a winner announced in Q1 2026.

AI by HER’s Global Impact Challenge invites women-led teams to present AI solutions addressing public-interest problems, offering awards up to US$300,000. Entries close 30 November 2025. Up to 30 teams will present at the India-AI Impact Summit in New Delhi in February 2026 and receive mentoring on responsible AI and investor readiness, culminating in an investor pitch session. Teams must be women-led, meaning a woman founder or principal investigator holds a significant leadership role and equity or leads the research.

Endometriosis refers to tissue similar to the womb lining growing outside the uterus, often causing pain and fertility problems. Heavy menstrual bleeding means frequent or prolonged blood loss that disrupts daily life.

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WHO hosts parliamentary dialogue on women’s health

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The World Health Organization (WHO) welcomed a delegation of parliamentarians to its Geneva headquarters for a high-level dialogue on women’s health and sexual and reproductive health and rights.

The meeting on 20 January 2026 focused on women’s health, sexual and reproductive health and rights, noncommunicable diseases (long-term conditions such as cancer and diabetes) and global health cooperation.

The exchange was convened by the Konrad-Adenauer-Stiftung and the UNITE Parliamentarians Network for Global Health, bringing together parliamentarians from Albania, Germany, Georgia, Mexico, Slovakia, South Africa, Sri Lanka, Sweden and Zimbabwe.

A central theme was the need to move beyond fragmented approaches to women’s health.

Dr Alia El-Yassir, WHO director for gender, equity and diversity, highlighted that outcomes are shaped by gender inequalities, social norms and structural barriers across the life course, requiring coordinated action across health systems.

Thirty years after the Beijing Declaration and Platform for Action, a landmark framework adopted in 1995 to advance gender equality and women’s rights, Dr Anna Coates, WHO gender equality technical lead, noted that progress on women’s health remains uneven.

She called for health systems that are more gender-responsive and able to address women’s health holistically across the life course.

Parliamentarians stressed that health is inseparable from wider social and economic policies, and called for stronger links between evidence, legislation and measurable impact at country level.

The meeting also focused on sexual and reproductive health and rights, where parliamentarians expressed interest in engaging on issues that directly affect their constituents.

Dr Pascale Allotey, director of WHO’s Department of Sexual, Reproductive, Maternal, Child, Adolescent Health and Ageing, outlined WHO’s life-course approach to sexual and reproductive health and rights.

She highlighted how needs evolve from birth to older age and how these are shaped by social determinants, humanitarian crises and demographic trends.

Dr Allotey underscored the role of parliamentarians in advancing sexual and reproductive health and rights and the importance of continued engagement with WHO to support evidence-based policy-making.

The agenda highlighted cancer as a growing priority for women’s health and for health system sustainability. Dr Prebo Barango, lead for the Cervical Cancer Elimination Initiative, Dr Meghan Doherty, consultant for palliative care, and Santiago Milan, lead for the WHO Global Platform for Access to Childhood Cancer Medicine, presented WHO’s integrated approach to cancer control.

Palliative care is treatment and support that aims to improve quality of life for people with serious illness by managing pain and other symptoms.

The discussion underlined the need for sustained political commitment and domestic investment to address noncommunicable diseases.

Parliamentarians shared national experiences showing the social and economic impacts of cancer on families and caregivers, reinforcing the importance of improving health literacy, reducing stigma and delivering people-centred care.

The meeting also addressed the state of global multilateralism.

Dr Jeremy Farrar, assistant director-general for health promotion, disease prevention and care, outlined how WHO has restructured to enhance efficiency, impact and capacity to support countries.

He reaffirmed WHO’s commitment to more systematic engagement with parliaments, recognising their role in shaping health policy, legislation and budgets.

The exchange concluded with a call for continued collaboration, including through partnerships with the Konrad-Adenauer-Stiftung and the UNITE Parliamentarians Network for Global Health, ahead of the UNITE Global Summit 2026 on 6–7 March in Manila, the Philippines.

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FDA approves Agilent test for ovarian cancer

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Agilent has FDA approval for a test to identify ovarian cancer patients who may be eligible for immunotherapy.

Agilent’s PD-L1 IHC 22C3 pharmDx is the only FDA-approved companion diagnostic to help identify patients with epithelial ovarian, fallopian tube or primary peritoneal carcinoma whose tumours express PD-L1 and who may be eligible for treatment with KEYTRUDA, Merck’s anti-PD-1 therapy.

A companion diagnostic is a test used alongside a specific treatment to show whether a patient is suitable for that therapy. PD-L1 is a protein on some cancer cells that helps tumours evade the immune system.

These cancers affect the reproductive system and the lining of the abdominal cavity.

The test enables pathologists to assess PD-L1 expression at diagnosis to support treatment decisions in a disease where options remain limited for many.

This is the seventh FDA-approved companion diagnostic indication for PD-L1 IHC 22C3 pharmDx for use with KEYTRUDA.

Nina Green, vice president and general manager of Agilent’s clinical diagnostics division, said: “Delivering effective precision oncology requires close collaboration between diagnostics and therapeutics, and this FDA approval reflects Agilent’s long-standing industry partnership in companion diagnostics.

“We are proud to enable pathologists to identify patients with EOC who may benefit from immunotherapy.

“As the first immuno-oncology approval for this disease, this milestone underscores our commitment to advancing precision medicine and expanding access to innovative cancer treatments worldwide.”

PD-L1 expression with this test was evaluated in the KEYNOTE-B96 clinical trial supporting its use to identify patients who may benefit from KEYTRUDA.

In the US, ovarian cancer caused approximately 12,730 deaths in 2025 and the five-year survival rate was 51.6 per cent between 2015 and 2021.

In addition to these cancer types, the test is indicated in the US to help identify patients with non-small cell lung cancer, oesophageal squamous cell carcinoma, cervical cancer, head and neck squamous cell carcinoma, triple-negative breast cancer and gastric or gastro-oesophageal junction adenocarcinoma who may benefit from treatment with KEYTRUDA.

The test was developed by Agilent with Merck as a companion diagnostic for KEYTRUDA.

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Topical HRT protects bone density in women with period loss – study

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Transdermal HRT best protects bone density in women with functional hypothalamic amenorrhoea, a condition that stops periods, a review of trials has found.

The meta-analysis pooled randomised clinical trials involving 692 participants and found transdermal hormone replacement therapy and teriparatide increased bone mineral density by between 2 and 13 per cent.

Functional hypothalamic amenorrhoea can follow anorexia or intense exercise. Bone mineral density measures bone strength and the amount of mineral in bone.

Around half of women with the condition have low bone mineral density, compared with about 1 per cent of healthy women, and their fracture risk is up to seven times higher.

The research was conducted by scientists at Imperial College London and Imperial College Healthcare NHS Trust.

Professor Alexander Comninos, senior author of the study and consultant endocrinologist at the trust, said: “Bone density is lost very rapidly in FHA and so addressing bone health early is very important to reduce the lifelong risk of fractures.

“Our study provides much needed comparisons of all the available treatments from all available studies.

“Clearly the best treatment is to restore normal menstrual cycles and therefore oestrogen levels through various psychological, nutritional or exercise interventions – but that is not always possible.

“The foundation for bone health is good calcium and vitamin D intake (through diet and/or supplements) but we have additional treatments that are more effective.”

When FHA is diagnosed, clinicians first try to restore periods through lifestyle measures, including psychological and dietary support, but these can fail. Guidelines then recommend giving oestrogen, though the best form was unclear.

The team reviewed all prior randomised trials comparing therapies, including oral and transdermal oestrogen, and also assessed teriparatide, a prescription bone-building drug used for severe osteoporosis.

They found no significant benefit for oral contraceptive pills or oral hormone therapy.

A recent UK audit reported that about a quarter of women with anorexia-related FHA are prescribed the oral contraceptive pill for bone loss; the study suggests using transdermal therapy instead.

Comninos said: “Our goal is simple: to help women receive the right treatment sooner and to protect their bone health in the long-term.

“We hope this study provides clinicians with better evidence to choose transdermal oestrogen when prescribing oestrogen and so inform future practice guidelines.

“Right now, millions of women with FHA may not be receiving the best treatments for their bone health.”

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