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News
Fertility biopharma company bags US$14m led by Google Ventures
Around one in four women who struggle with infertility have difficulty carrying a pregnancy to term
The US biopharma company Granata Bio has secured US$14m in Series A funding to develop new fertility treatments.
Nearly one in five women in the US struggle with infertility and are unable to get pregnant after one year of trying according to the Centers for Disease Control and Prevention. Approximately one in four women in this group have difficulty getting pregnant or carrying a pregnancy to term.
Problems that affect ovulation and the hormones involved with ovulation, are the most common cause of female infertility and are often treated with infertility drugs as a first step.
Granata Bio launched in 2018 with the aim to “invigorate” the offerings in the US fertility medication marketplace.
The company has designed clinical development programmes aimed at optimising outcomes for study subjects while assessing the safety and efficacy of investigational products. It currently has a portfolio of four medications.
The funding round, led by Google Ventures (GV) with participation from CooperSurgical, Gedeon Richter, Alumni Ventures, Amboy Street Ventures and Vibe Bio, is hoped to help Granata evaluate new targets and accelerate its existing pipeline.
“We are taking a novel approach to both address current market dynamics and to develop unique products targeting unmet needs in women’s health,” said Evan Sussman, Granata CEO.
“This funding is an exciting next step toward our mission of creating access for fertility patients with new therapeutic solutions.”
Cathy Friedman, executive venture partner at GV, said: “Despite significant growth in patient volume over the last ten years, infertility has been woefully overlooked and under-supported.
“We’re excited about the focus and innovation Granata Bio is bringing to this space and – most importantly – new options for patient care.”
She added: “We look forward to partnering with Evan Sussman and the Granata Bio team as they advance women’s health.”
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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