News
Eating disorder treatment platform expands services to adults
Equip aims to close significant gaps in the traditional treatment landscape in the US
The US virtual care platform Equip has expanded its eating disorder services to adults, in a move that could help millions access treatment.
Equip is an online provider that aims to help people struggling with eating disorders through dedicated virtual care teams and at-home treatment.
Created by clinical experts in the field and people with lived experience, the programme builds upon “evidence-based” treatments to help individuals reach lasting recovery.
Nearly 30 million Americans struggle with an eating disorder in their lifetime. However, only a small fraction of people get support, with as many as 80 per cent ending up without treatment.
Studies show women are disproportionately affected by eating disorders, as a higher percentage are concerned with their body image than men.
Equip’s expansion to adults aims to close significant gaps in the traditional treatment landscape.
“Since Equip’s inception in 2019, we have been laser-focused on providing effective treatment to thousands of adolescents and young adults with eating disorders,” said Dr Erin Parks, co-founder and chief clinical officer at Equip.
“We know, though, that eating disorders don’t discriminate by age, gender, socioeconomic status, or body size.
“By broadening our treatment to adults, we are expanding hope to every person with an eating disorder that they can rediscover a more meaningful life on the other side of their illness.”
How it started
After her anorexia diagnosis at 10, Kristina Saffran spent years in and out of hospitals and treatment centres until her family discovered family-based treatment (FBT) and she finally recovered.
Dr Parks, meanwhile, saw the success of FBT and other evidence-based eating disorder approaches while working with patients at the UCSD Eating Disorders Center.
Both were encouraged by the effectiveness of the treatment, but frustrated at how few people had access to it. After combined decades of personal, professional, and clinical experience in the field, Saffran and Parks knew they had to make a change.
They joined forces to create an affordable treatment model for eating disorders and in 2019, they founded Equip.
Growth and expansion
Initially launched as a platform for children and young adults, Equip’s latest expansion marks a landmark moment for the company, showcasing continued momentum.
It’s buoyed by a recent additional investment from General Catalyst, one of Equip’s early investors, which is hoped to fuel the company’s expansion.
Earlier this year, Equip published its first annual outcomes report, which revealed that patients saw their symptoms reduced by at least 50 per cent in their first five months of treatment.
Additionally, 94 per cent of all Equip patients had their treatment covered by insurance as a result of strategic partnerships with many leading commercial insurance plans and Medicaid.
Today, the company treats patients in all 50 US states, including the nine US states that lack an in-person treatment centre entirely.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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