News
Digital health start-up raises US$7m to advance equity in clinical trials
Acclinate seeks to mobilise diverse communities to enhance equity in clinical trials
The US digital health start-up Acclinate has raised US$7m in Series A funding to improve equity in clinical trials.
Acclinate aims to drive diversity in clinical trials with a community engagement platform that promises to help make existing trials more inclusive and plan more diverse studies moving forward.
The Alabama-based company uses a combination of community engagement and predictive analytics to help pharmaceutical companies increase diversity in their trials and other healthcare organisations support inclusivity in their initiatives.
Led by Cencora Ventures, with participation from Labcorp and Latimer Ventures, the funding is hoped to enable Acclinate to scale its impact in the clinical trial diversity and health equity landscapes.
“This round of funding allows us to continue the work that moves clinical trial diversity forward,” Tiffany Whitlow, co-founder and chief development officer at Acclinate, told Femtech World.
“We know that under-resourced communities must be uniquely engaged. With more resources, our team can produce even more targeted efforts, including technology-based and grassroots tactics which will help us reach a demographic that is least engaged and simultaneously most needed in clinical research.
“Likewise, this funding also means we are edging closer towards bridging the gap between the healthcare industry and the communities that stand to reap a direct and generational benefit from more diverse research.”
Del Smith, co-founder and CEO of Acclinate, said: “This investment marks a significant milestone for Acclinate and underscores our commitment to revolutionising health equity and clinical trial diversity at a larger scale.
“With the backing of prominent healthcare organizations like Cencora and Labcorp, we are poised to accelerate tangible change in the healthcare industry and empower diverse communities to proactively manage their health.”
The funding, Smith said, will help “fuel” Acclinate’ s expansion and help improve its Enhanced Diversity in Clinical Trials (e-DICT) platform.
“As Acclinate continues to pioneer initiatives aimed at inclusivity and equity in healthcare, this infusion of capital propels our mission forward, bringing us one step closer to a future where healthcare is truly accessible to all,” he added.
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Cancer
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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