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Hormonal health

Study reveals why women more likely to get severe long Covid

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New research has uncovered biological differences that explain why women with long Covid experience more severe and persistent symptoms than men.

Long Covid is diagnosed when neurological, respiratory or gastrointestinal symptoms persist for three months or more after SARS-CoV-2 infection.

Women are about three times more likely than men to develop it, but the biology behind this gap has been unclear.

The research from the University of Alberta suggests potential treatment targets that could help the 3.5 million Canadians who reported long Covid as of June 2023, according to Statistics Canada.

Principal investigator Shokrollah Elahi is an immunology professor in the Mike Petryk School of Dentistry.

The researcher said: “We are focusing on a subset of patients with the most devastating symptoms that are very similar to chronic fatigue syndrome.

“They didn’t have these symptoms prior to Covid and most had only mild Covid-19 disease, so they were not hospitalised.”

Elahi’s team ran blood and genetic tests on 78 patients with long Covid one year after their acute diagnosis, plus 62 controls who did not develop long Covid after infection.

By analysing immune cells, blood biomarkers (measurable signals of disease) and RNA sequencing (a method to read gene activity), the researchers identified a distinct immune signature in female versus male patients.

They found evidence of “gut leakiness” in female patients — when the intestinal barrier becomes more permeable and allows substances to pass into the bloodstream — including raised levels of intestinal fatty acid-binding protein, lipopolysaccharide and soluble CD14.

These signs of gut inflammation can trigger wider inflammation once in circulation.

“This suggests that probably at the earliest stage of disease when patients get acute SARS-CoV-2 infection, there is a tendency that the females’ guts are more prone to viral infection,” Elahi said.

The team also observed lower red blood cell production — anaemia — in female patients, suggesting elevated inflammatory factors in women with long Covid may impair blood formation.

In addition, they reported dysregulated sex hormones in long Covid: reduced testosterone in affected women, decreased oestrogen in male patients, and lower cortisol in both.

Women with lower testosterone had higher inflammatory markers. Because testosterone can help dampen inflammation, reduced levels may leave women more vulnerable to ongoing inflammatory responses. Lower testosterone was also linked to brain fog, depression, pain and fatigue.

The findings suggest hormone imbalance plays an important role in long Covid, particularly in how it affects women, Elahi said.

These results mirror some features of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), which also disproportionately affects women.

For example, chronic inflammation is common to both, although anaemia is not typically associated with chronic fatigue.

The team’s conclusions are supported by another recent international study of more than 500 patients that also identified anaemia as a major biological driver of long Covid.

Elahi plans to validate the findings by testing potential treatments in mouse models of long Covid and is seeking funding for a clinical trial.

He proposes an individualised approach guided by test results that could include anaemia treatment, anti-inflammatory medicines and, in some cases, sex hormones.

He also aims to further explore similarities between neurological symptoms of long Covid and those seen in HIV.

Opinion

The $128b paradox: Corporate wellness vs women’s burnout

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By Katrina Zalcmane, co-founder | partnerships and growth, Véa

The global corporate wellness market reached US$70.65 billion in 2024 and is projected to hit US$128 billion by 2033 – Europe leads the charge, capturing over 39.5 per cent of market share.

Meanwhile, femtech investment hit US$2.2 billion in 2024, representing 8.5 per cent of all digital health funding.

The message is clear: companies recognise that employee wellness matters and women’s health technology is finally getting serious investment.

So why are women still drowning?

In the UK, 91 per cent of adults report experiencing high or extreme stress levels – despite consumers spending an average of US$3,342 annually on wellness and self-care.

60 per cent of women in leadership positions report feeling constantly burned out, while 69 per cent of women feel emotionally drained after every workday.

Around 1 in 4 working women say they can’t manage workplace stress, with only 44 per cent confident their employer even has a burnout plan.

The numbers don’t add up. Billions flowing into wellness programmes. A femtech revolution promising personalised solutions.

And yet women ages 25-45 – the backbone of the modern workforce – are hitting crisis levels of exhaustion.

The problem isn’t a lack of investment – it’s what we’re investing in.

The Mismatch: What Companies Offer vs What Women Actually Need

Health risk assessments captured 21.2 per cent of the European corporate wellness market in 2024, while stress management programmes hold 13 per cent market share and continue expanding.

Companies are checking boxes: biometric screenings, mental health apps, flexible work, meditation subscriptions.

Yet these programmes consistently miss three critical factors:

1. Emotional data is invisible

Modern workplaces reward thinking, problem-solving and constant cognitive output.

What gets lost is the intelligence that comes from recognising early warning signals in the body – somatic indicators that burnout is building long before it becomes visible.

Women are taught to “think through” stress rather than listen to what their bodies are telling them. By the time burnout shows up in productivity metrics or sick days, the damage is done.

2. Hormonal rhythms are ignored

Corporate wellness assumes constant, linear productivity.

But women’s bodies don’t work that way. Menstrual cycles, perimenopause, fertility journeys – all create natural energy fluctuations that impact focus, stress response and cognitive performance.

Instead of working with these rhythms, most women fight against them, blaming themselves for “productivity dips” that are actually biological.

The result is chronic disconnection from their bodies and accelerated burnout.

3. Emotional labour stays uncounted

Women carry disproportionate loads of invisible work – managing team dynamics, mentoring, smoothing conflicts, holding space for others’ stress.

This labour never appears on performance reviews or workload assessments.

It accumulates beneath the surface until women hit a wall.

The Cost of Getting It Wrong

In the UK, mental health-related absences cost the economy approximately £21.6 billion annually, with employees taking 34 million sick days each year due to stress, depression and anxiety.

Employee burnout costs an average 1,000-person company US$5.04 million per year globally. Burned-out employees are 6 times more likely to leave, costing companies 50-200 per cent of salary in recruiting and training.

For women specifically, the crisis deepens.

Women new to leadership report 70 per cent burnout rates; for women of colour in senior positions, it reaches 77 per cent..

Nearly 40 per cent of women actively seeking new jobs cite burnout as the primary reason.

Replacing a mid- or senior-level woman costs up to 213 per cent of her annual salary.

We’re not just losing individual contributors but hemorrhaging the women leaders who hold institutional knowledge, mentor the next generation and drive diversity initiatives.

What Needs to Change

Instead of more generic wellness programs, we need to fundamentally rethink how we support women at work.

1. Shift from crisis response to prevention

Only 44 per cent of women feel confident their employer has a burnout plan – but by then, you’ve already lost.

Companies must teach women to recognise burnout signals in their bodies before a crisis hits. Somatic awareness catches exhaustion early, when intervention still works.

2. Design work around cyclical energy, not constant output

Women need organisational cultures that acknowledge hormonal rhythms as legitimate biological factors affecting performance.

This means training managers to understand energy fluctuations and designing workloads that account for them instead of just offering “flexible arrangements”.

3. Make invisible labour visible

Emotional labor must be quantified, acknowledged and redistributed.

This requires new frameworks for measuring contributions beyond traditional output metrics and structural changes preventing this work from defaulting to women.

4. Prioritise personalisation over one-size-fits-all

Workforce wellness now centres on personalisation powered by AI and data analytics.

A 27-year-old establishing her career has completely different needs than a 42-year-old navigating perimenopause while caring for ageing parents.

AI-driven platforms can deliver tailored support – virtual health assistants, personalised insights, telemedicine – making care more accessible for women balancing careers, family and wellness.

The Opportunity

Closing the women’s health gap could add at least $1 trillion annually to the global economy by 2040.

But unlocking that value requires interventions addressing burnout’s root causes, not just symptoms.

The market is already voting.

Virtual workplace wellness programmes saw substantial growth following the pandemic and Europe continues leading corporate wellness investment.

Companies in the UK and France are implementing AI-driven burnout assessments, hybrid wellness platforms and data-driven mental health monitoring.

Still, investment alone isn’t enough.

The question isn’t whether companies will spend on women’s wellness – they already are.

The question is whether they’ll invest in solutions that actually work: reconnecting women with somatic intelligence before burnout becomes visible, designing around hormonal rhythms rather than fighting them and making invisible labour visible so it can be redistributed.

The companies that do will win the talent war.

The ones that don’t will keep wondering why their best women keep leaving.

About Véa Workshops

Véa offers evidence-based corporate wellness workshops designed specifically for women professionals, addressing the root causes of burnout that traditional programs miss.

Grounded in neuroscience, psychology and somatic awareness, Véa workshops focus on prevention rather than crisis response – teaching women to recognise emotional data and somatic signals, work sustainably with hormonal rhythms and make invisible labor visible.

Available in formats from 45-minute executive sessions to half-day leadership offsites, these workshops support sustainable performance without asking women to step back from ambition.

Learn more at veajournal.app/workshops.

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Menopause

Medichecks acquires My Menopause Centre to expand specialist hormone health services

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Digital diagnostics company Medichecks has acquired specialist menopause health platform and clinic My Menopause Centre.

The deal is part of Medichecks’ move into clinical services and follows its earlier purchase of Leger Clinic, creating what the company describes as a hormone health offering for women and men across the UK.

Medichecks and My Menopause Centre will combine digital services with clinical governance. The acquisition aims to enhance Medichecks’ ability to deliver integrated testing, diagnosis and ongoing clinical support.

The combined group plans to grow its specialist hormone health services, supporting patients across the UK with clinical care throughout different stages of their hormone health journey.

Helen Marsden, co-founder of Medichecks, said: “At Medichecks, our mission is to make healthcare more accessible, evidence-based and patient-centred.

“Helen and Clare have built an outstanding, clinically credible platform that is transforming menopause care for women across the UK.

“Medichecks now owns two CQC Outstanding-rated clinics, the only clinics in their respective sectors to achieve this rating, and we are deeply committed to delivering safe, compassionate and patient-centric care.

“We’re proud to continue the founders’ legacy while supporting the next stage of growth, ensuring more women can access high-quality menopause care when they need it most.”

The CQC, or Care Quality Commission, is the independent regulator of health and social care in England.

The acquisition supports Medichecks’ plans to make hormone healthcare more accessible by delivering integrated testing, diagnosis and ongoing clinical support for patients across the UK.

Helen Normoyle, co-founder and chief executive of My Menopause Centre, said: “We set out to build something resilient, clinically credible and scalable, not just fast.

“Our mission has always been to make menopause care compassionate, accessible and grounded in evidence. Medichecks shares that vision.

“Their digital platform, commitment to clinical excellence and patient-centred care make them the ideal partner to take My Menopause Centre into its next chapter.

“This milestone reflects not only a strong product, but a remarkable team and community.

“I’m deeply proud of what we’ve built and excited to see My Menopause Centre grow further under Medichecks’ leadership.”

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Menopause

Menopause specialist Haver joins Midi Health

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Menopause specialist Dr Mary Claire Haver has been appointed as the first chief agewell officer at virtual care clinic Midi Health.

In the role, Dr Haver will work with Midi’s clinical team to develop the AgeWell platform, described as a proactive health model that integrates perimenopause and menopausal care with metabolic health, bone density, brain health and cardiovascular risk assessment.

The platform aims to provide preventative care targeting what the company describes as the primary drivers of female mortality and disability: heart disease, bone loss and cognitive decline.

Joanna Strober, chief executive and co-founder of Midi Health, said: “Longevity care has historically ignored women’s biology, especially during the critical windows of midlife and menopause.

“At Midi Health, we are committed to extending healthspan, not just lifespan, and making that care accessible to millions of women as a core pillar of their health.

“By collaborating with Dr Haver, we are ensuring women continue to have access to care designed for their bodies, their hormones, and their real lives.”

Dr Haver is board-certified in obstetrics and gynaecology, a Menopause Society certified practitioner, a certified culinary medicine specialist and an adjunct associate professor of obstetrics and gynaecology at The University of Texas Medical Branch.

After a career in academic medicine, Dr Haver founded The Pause Life, described as a science and education-based resource for women navigating perimenopause and the menopause transition.

Through her books, unPaused podcast and digital platform, she has provided education on midlife health.

Dr Mary Claire Haver said: “I have spent my career advocating for women to receive the science-backed, no-nonsense guidance they deserve.

“I chose to partner with Midi Health because they are the only platform with the scale and medical rigour to deliver the kind of care women deserve, regardless of their zip codes.

“Together, we are setting a new standard for proactive, preventative care that meaningfully extends both lifespan and healthspan for women.”

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